GNAS knockout potentiates HDAC3 inhibition through viral mimicry-related interferon responses in lymphoma
Sign Up to like & getrecommendations! Published in 2024 at "Leukemia"
DOI: 10.1038/s41375-024-02325-4
Abstract: Despite selective HDAC3 inhibition showing promise in a subset of lymphomas with CREBBP mutations, wild-type tumors generally exhibit resistance. Here, using unbiased genome-wide CRISPR screening, we identify GNAS knockout (KO) as a sensitizer of resistant… read more here.
Keywords: inhibition; hdac3 inhibition; gnas knockout; mimicry related ... See more keywords
Molecular vasculogenic mimicry–Related signatures predict clinical outcomes and therapeutic responses in bladder cancer: Results from real-world cohorts
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2023.1163115
Abstract: Bladder cancer (BLCA) is a heterogeneous disease, and there are many classical molecular subtypes that reflect tumor immune microenvironment (TME) heterogeneity but their clinical utility is limited and correct individual treatment and prognosis cannot be… read more here.
Keywords: molecular subtypes; mimicry related; bladder cancer; molecular vasculogenic ... See more keywords