Chemical inducer of regucalcin attenuates lipopolysaccharide-induced inflammatory responses in pancreatic MIN6 β-cells and RAW264.7 macrophages.
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DOI: 10.1002/2211-5463.13321
Abstract: We previously isolated derrisfolin A, a novel rotenoid derivative, from the stems of Derris trifoliata Lour. (Leguminosae). Here, we report that derrisfolin A induces the expression of endogenous regucalcin (RGN) protein in both pancreatic MIN6… read more here.
Keywords: raw264 macrophages; lps induced; min6 cells; cells raw264 ... See more keywords
Dimethyl sulfoxide acutely enhances regulated insulin secretion in the MIN6-K8 mouse insulinoma cell line.
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DOI: 10.1007/s00418-021-01984-z
Abstract: Diabetes mellitus is a metabolic disorder projected to afflict 700 million people globally by 2045. Fundamental to the progression of diabetes is an insufficient supply of insulin to meet metabolic demand. The MIN6-K8 cell line… read more here.
Keywords: insulin secretion; secretion; cell line; min6 ... See more keywords
Cadmium inhibits signal transducer and activator of transcription 6 leading to pancreatic β cell apoptosis.
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DOI: 10.1507/endocrj.ej21-0115
Abstract: The toxic heavy metal cadmium has been proven to cause pancreatic dysfunction and lead to the development of DM. However, the underlying mechanisms have not been completely elucidated. Here, we investigated the effects of cadmium… read more here.
Keywords: pancreatic cell; apoptosis; activator; min6 ... See more keywords