LAUSR

First-in-Class Inhibitors of the Ribosomal Oxygenase MINA53

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1 Published in 2021 at "Journal of Medicinal Chemistry"

DOI: 10.1021/acs.jmedchem.1c00605

Abstract: MINA53 is a JmjC domain 2-oxoglutarate-dependent oxygenase that catalyzes ribosomal hydroxylation and is a target of the oncogenic transcription factor c-MYC. Despite its anticancer target potential, no small-molecule MINA53 inhibitors are reported. Using ribosomal substrate… read more here.

Keywords: class inhibitors; mina53; oxygenase; first class ... See more keywords