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   Articles with "mincle" as a keyword



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Quercetin protects against cisplatin‐induced acute kidney injury by inhibiting Mincle/Syk/NF‐κB signaling maintained macrophage inflammation

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recommendations! Published in 2019 at "Phytotherapy Research"

DOI: 10.1002/ptr.6507

Abstract: Acute kidney injury (AKI) with high incidence and mortality is the main cause of chronic kidney disease. Previous studies have indicated that quercetin, an abundant flavonoid in plants, exhibited renoprotective role in AKI. However, the… read more here.

Keywords: mincle syk; macrophage inflammation; quercetin; mincle ... See more keywords
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The Mycobacterial Adjuvant Analogue TDB Attenuates Neuroinflammation via Mincle-Independent PLC-γ1/PKC/ERK Signaling and Microglial Polarization

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recommendations! Published in 2018 at "Molecular Neurobiology"

DOI: 10.1007/s12035-018-1135-4

Abstract: Microglial activation has long been recognized as a hallmark of neuroinflammation. Recently, the bacillus Calmette-Guerin (BCG) vaccine has been reported to exert neuroprotective effects against several neurodegenerative disorders. Trehalose-6,6′-dibehenate (TDB) is a synthetic analogue of… read more here.

Keywords: microglial polarization; plc pkc; polarization; tdb ... See more keywords
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Astragalus propinquus Schischkin and Panax notoginseng (A&P) compound relieved cisplatin-induced acute kidney injury through inhibiting the mincle maintained macrophage inflammation.

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recommendations! Published in 2020 at "Journal of ethnopharmacology"

DOI: 10.1016/j.jep.2020.112637

Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Acute kidney injury (AKI) is a common disease in hospitalized patients, especially in critically ill patients. It is characterised with high morbidity and mortality, and is also an important cause of chronic kidney… read more here.

Keywords: medicine; astragalus propinquus; inflammation; macrophage ... See more keywords
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M1 macrophage triggered by Mincle leads to a deterioration of acute kidney injury.

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recommendations! Published in 2017 at "Kidney international"

DOI: 10.1016/j.kint.2016.11.026

Abstract: In the early stage of acute kidney injury, M1 macrophages are proinflammatory and destructive. In this study, Lv et al. reveal that Mincle (macrophage-inducible C-type lectin, Clec4e) is expressed on M1 macrophages in acute kidney injury,… read more here.

Keywords: kidney injury; acute kidney; macrophage; mincle ... See more keywords
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Synthetic mycobacterial diacyl trehaloses reveal differential recognition by human T cell receptors and the C-type lectin Mincle

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recommendations! Published in 2021 at "Scientific Reports"

DOI: 10.1038/s41598-021-81474-3

Abstract: The cell wall of Mycobacterium tuberculosis is composed of diverse glycolipids which potentially interact with the human immune system. To overcome difficulties in obtaining pure compounds from bacterial extracts, we recently synthesized three forms of… read more here.

Keywords: synthetic mycobacterial; recognition; dat1 dat2; mincle ... See more keywords
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Synthetic vaccines targeting Mincle through conjugation of trehalose dibehenate.

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recommendations! Published in 2022 at "Chemical communications"

DOI: 10.1039/d2cc02100e

Abstract: The covalent fusion of immunostimulatory adjuvants to immunogenic antigens is a promising strategy for the development of effective synthetic vaccines for infectious diseases. Herein, we describe the conjugation of a mycobacterial peptide antigen from the… read more here.

Keywords: vaccines targeting; mincle; conjugation; synthetic vaccines ... See more keywords
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Human MCL forms a heteromeric receptor complex with Mincle but not Dectin-2.

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recommendations! Published in 2022 at "Scandinavian journal of immunology"

DOI: 10.1111/sji.13149

Abstract: MCL, Mincle and Dectin-2 are C-type lectin receptors expressed by subsets of myeloid cells, and their genes cluster together in the APLEC/Dectin-2 gene complex. We have previously shown that MCL and Mincle form a heterodimer… read more here.

Keywords: human mcl; mcl mincle; mcl; mincle ... See more keywords
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Macrophage inducible C-type lectin (Mincle) recognizes glycosylated surface (S)-layer of the periodontal pathogen Tannerella forsythia

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recommendations! Published in 2017 at "PLoS ONE"

DOI: 10.1371/journal.pone.0173394

Abstract: The oral pathogen Tannerella forsythia is implicated in the development of periodontitis, a common inflammatory disease that leads to the destruction of the gum and tooth supporting tissues, often leading to tooth loss. T. forsythia… read more here.

Keywords: tannerella forsythia; layer; macrophage; mincle ... See more keywords
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NOD1/2 and the C-Type Lectin Receptors Dectin-1 and Mincle Synergistically Enhance Proinflammatory Reactions Both In Vitro and In Vivo

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recommendations! Published in 2020 at "Journal of Inflammation Research"

DOI: 10.2147/jir.s245638

Abstract: Purpose Pathogens consist of a wide variety of evolutionarily conserved molecular structures that are recognized by pattern recognition receptors (PRRs) of innate immunity. Reasonably assuming that no single PRR is ever likely to be the… read more here.

Keywords: mincle; type lectin; vitro vivo; lectin receptors ... See more keywords
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Monocytes Elicit a Neutrophil-Independent Th1/Th17 Response Upon Immunization With a Mincle-Dependent Glycolipid Adjuvant

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recommendations! Published in 2022 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2022.880474

Abstract: Successful subunit vaccination with recombinant proteins requires adjuvants. The glycolipid trehalose-dibehenate (TDB), a synthetic analog of the mycobacterial cord factor, potently induces Th1 and Th17 immune responses and is a candidate adjuvant for human immunization.… read more here.

Keywords: immunization; monocytes elicit; th17; mincle ... See more keywords
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Dependence on Mincle and Dectin-2 Varies With Multiple Candida Species During Systemic Infection

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recommendations! Published in 2021 at "Frontiers in Microbiology"

DOI: 10.3389/fmicb.2021.633229

Abstract: More than 95% of invasive Candida infections are caused by four Candida spp. (C. albicans, C. glabrata, C. tropicalis, C. parapsilosis). C-type lectin-like receptors (CLRs), such as Dectin-1, Dectin-2, and Mincle mediate immune responses to… read more here.

Keywords: candida; candida spp; dectin; mincle ... See more keywords