Alternate soaking enables easy control of mineralized collagen scaffold mechanics from nano- to macro-scale.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the mechanical behavior of biomedical materials"
DOI: 10.1016/j.jmbbm.2020.103863
Abstract: The mechanical properties of biologic scaffolds are critical to cellular interactions and hence functional response within the body. In the case of scaffolds for bone tissue regeneration, engineered scaffolds created by combining collagen with inorganic… read more here.
Keywords: collagen; mineralized collagen; mineralization cycles; alternate soaking ... See more keywords
Percolation networks inside 3D model of the mineralized collagen fibril
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-90916-x
Abstract: Bone is a hierarchical biological material, characterized at the nanoscale by a recurring structure mainly composed of apatite mineral and collagen, i.e. the mineralized collagen fibril (MCF). Although the architecture of the MCF was extensively… read more here.
Keywords: collagen; mineralized collagen; percolation; collagen fibril ... See more keywords
A coarse-grained molecular dynamics investigation of the role of mineral arrangement on the mechanical properties of mineralized collagen fibrils
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the Royal Society Interface"
DOI: 10.1098/rsif.2022.0803
Abstract: Mineralized collagen fibrils (MCFs) comprise collagen molecules and hydroxyapatite (HAp) crystals and are considered universal building blocks of bone tissue, across different bone types and species. In this study, we developed a coarse-grained molecular dynamics… read more here.
Keywords: mineralized collagen; role; collagen; grained molecular ... See more keywords
Enhancing strength in mineralized collagen.
Sign Up to like & getrecommendations! Published in 2022 at "Science"
DOI: 10.1126/science.abo1264
Abstract: X-ray data reveal the role of prestress in hierarchical biocomposites at the nanoscale. read more here.
Keywords: strength mineralized; enhancing strength; mineralized collagen;
In vitro evaluation of freeze-drying chitosan-mineralized collagen/Mg–Ca alloy composites for osteogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biomaterials Applications"
DOI: 10.1177/08853282211049296
Abstract: Magnesium (Mg) alloy with good mechanical properties and biodegradability is considered as one of the ideal bone repair materials. However, the rapid corrosion of Mg-based metals can pose harm to the function of an implant… read more here.
Keywords: matrix; mineralized collagen; collagen; chitosan mineralized ... See more keywords
The clinical results of treating Kummell’s disease with mineralized collagen modified polymethyl methacrylate
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Biomaterials Applications"
DOI: 10.1177/0885328221990821
Abstract: To investigate the clinical results of treating Kummell’s Disease by using mineralized collagen modified polymethyl methacrylate bone cement, 23 cases (23 vertebras) who sustained Kummell’s Disease treated with mineralized collagen modified polymethyl methacrylate bone cement… read more here.
Keywords: mineralized collagen; clinical results; kummell disease; polymethyl methacrylate ... See more keywords
3D Tortuosity and Diffusion Characterization in the Human Mineralized Collagen Fibril Using a Random Walk Model
Sign Up to like & getrecommendations! Published in 2023 at "Bioengineering"
DOI: 10.3390/bioengineering10050558
Abstract: Bone tissue is mainly composed at the nanoscale of apatite minerals, collagen molecules and water that form the mineralized collagen fibril (MCF). In this work, we developed a 3D random walk model to investigate the… read more here.
Keywords: tortuosity; diffusion; mineralized collagen; random walk ... See more keywords
Devising Bone Molecular Models at the Nanoscale: From Usual Mineralized Collagen Fibrils to the First Bone Fibers Including Hydroxyapatite in the Extra-Fibrillar Volume
Sign Up to like & getrecommendations! Published in 2022 at "Materials"
DOI: 10.3390/ma15062274
Abstract: At the molecular scale, bone is mainly constituted of type-I collagen, hydroxyapatite, and water. Different fractions of these constituents compose different composite materials that exhibit different mechanical properties at the nanoscale, where the bone is… read more here.
Keywords: bone; fibrillar volume; mineralized collagen; extra fibrillar ... See more keywords
Influence of Biomimetically Mineralized Collagen Scaffolds on Bone Cell Proliferation and Immune Activation
Sign Up to like & getrecommendations! Published in 2022 at "Polymers"
DOI: 10.3390/polym14030602
Abstract: Collagen, as the main component of connective tissue, is frequently used in various tissue engineering applications. In this study, porous sponge-like collagen scaffolds were prepared by freeze-drying and were then mineralized in a simulated body… read more here.
Keywords: biomimetically mineralized; mineralized collagen; influence biomimetically; collagen ... See more keywords