Obesity-Associated Heart Failure as a Theoretical Target for Treatment With Mineralocorticoid Receptor Antagonists
Sign Up to like & getrecommendations! Published in 2018 at "JAMA Cardiology"
DOI: 10.1001/jamacardio.2018.2090
Abstract: Importance Despite their clinical benefits, mineralocorticoid receptor antagonists are greatly underprescribed by most practitioners who treat patients with chronic heart failure. A novel approach to encouraging the use of these drugs is to enhance awareness… read more here.
Keywords: abdominal obesity; obesity; mineralocorticoid receptor; heart failure ... See more keywords
Mineralocorticoid receptor blockade with finerenone improves heart function and exercise capacity in ovariectomized mice
Sign Up to like & getrecommendations! Published in 2021 at "ESC Heart Failure"
DOI: 10.1002/ehf2.13219
Abstract: In post‐menopausal women, incidence of heart failure with preserved ejection fraction is higher than in men. Hormonal replacement therapies did not demonstrate benefits. We tested whether the non‐steroidal mineralocorticoid receptor antagonist finerenone limits the progression… read more here.
Keywords: heart; receptor blockade; heart failure; mineralocorticoid receptor ... See more keywords
Sex differences in mineralocorticoid receptor antagonist trials: a pooled analysis of three large clinical trials
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Heart Failure"
DOI: 10.1002/ejhf.1740
Abstract: Women with heart failure (HF) are under‐represented in individual randomized clinical trials (RCTs). Little is known about sex‐specific treatment effects in HF medications. We evaluated sex differences in the response to mineralocorticoid receptor antagonists (MRAs)… read more here.
Keywords: sex differences; mineralocorticoid receptor; sex; differences mineralocorticoid ... See more keywords
Stopping mineralocorticoid receptor antagonists after hyperkalemia: trial emulation in data from routine care.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of heart failure"
DOI: 10.1002/ejhf.2287
Abstract: AIMS Whether to continue or stop mineralocorticoid receptor antagonists (MRA) after an episode of hyperkalemia is a challenge in clinical practice. While stopping MRA may prevent recurrent hyperkalemias, it deprives patients of their cardioprotection. We… read more here.
Keywords: trial emulation; heart failure; mineralocorticoid receptor; hyperkalemia ... See more keywords
Temporal trends in initiation of mineralocorticoid receptor antagonists and risk of subsequent withdrawal in patients with heart failure: A nationwide study in Denmark from 2003-2017.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of heart failure"
DOI: 10.1002/ejhf.2418
Abstract: AIMS Despite landmark heart failure (HF) with reduced ejection fraction (HFrEF) trials showing effect of Mineralocorticoid Receptor Antagonists (MRA) on the risk of death and HF hospitalization, it has been suggested that MRAs are underutilized… read more here.
Keywords: mineralocorticoid receptor; receptor antagonists; heart failure; withdrawal ... See more keywords
A promise unfulfilled: the use of mineralocorticoid receptor antagonists in patients with heart failure and a reduced left ventricular ejection fraction
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Heart Failure"
DOI: 10.1002/ejhf.2441
Abstract: This article refers to ‘Temporal trends in initiation of mineralocorticoid receptor antagonists and risk of subsequent withdrawal in patients with heart failure: a nationwide study in Denmark from 2003–20 1 7’ by D. Zahir et… read more here.
Keywords: mineralocorticoid receptor; heart; receptor antagonists; patients heart ... See more keywords
Effects of steroidal mineralocorticoid receptor antagonists on acute and chronic estimated glomerular filtration rate slopes in patients with chronic heart failure
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Heart Failure"
DOI: 10.1002/ejhf.2635
Abstract: Steroidal mineralocorticoid receptor antagonists (MRAs) form a cornerstone of the management of heart failure (HF), but little is known about the long‐term effects of MRA therapy on kidney function. We evaluated acute and chronic estimated… read more here.
Keywords: heart failure; heart; mineralocorticoid receptor; receptor antagonists ... See more keywords
The effects of mineralocorticoid receptor antagonists on cardiovascular outcomes in patients with end‐stage renal disease and heart failure
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Heart Failure"
DOI: 10.1002/ejhf.2740
Abstract: Mineralocorticoid receptor antagonists (MRAs) have been shown to provide survival benefits in patients with heart failure; however, MRA use in patients with chronic kidney disease has been limited by safety concerns. The effects of MRAs… read more here.
Keywords: outcomes patients; heart failure; disease; heart ... See more keywords
Efficacy of mineralocorticoid receptor antagonist for central serous chorioretinopathy: a meta-analysis
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DOI: 10.1007/s10792-020-01479-1
Abstract: Purpose To evaluate the efficacy of mineralocorticoid receptor antagonist (MRA) for patients with central serous chorioretinopathy (CSCR). Methods The Pubmed, Embase, and the Cochrane Central Register of Controlled Trials were comprehensively searched up to February… read more here.
Keywords: receptor antagonist; central serous; efficacy; mineralocorticoid receptor ... See more keywords
An alternative splicing variant of mineralocorticoid receptor discovered in preeclampsia tissues and its effect on endothelial dysfunction
Sign Up to like & getrecommendations! Published in 2019 at "Science China Life Sciences"
DOI: 10.1007/s11427-018-9535-9
Abstract: The pathophysiology of preeclampsia (PE) remains unclear. PE spiral artery remodeling dysfunction and PE offspring cardiovascular future development has been a worldwide concern. We collected placental and umbilical artery samples from nor-motensive and PE pregnancies.… read more here.
Keywords: artery; dysfunction; splicing variant; mineralocorticoid receptor ... See more keywords
Mineralocorticoid Receptor Antagonists: a Comprehensive Review of Finerenone
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DOI: 10.1007/s11886-020-01399-7
Abstract: We aim to review the mechanism of action and safety profile of mineralocorticoid receptor antagonists (MRAs) and discuss the differences between selective and non-selective MRAs. More specifically, finerenone is a new medication that is currently… read more here.
Keywords: mineralocorticoid receptor; review; finerenone; receptor ... See more keywords