Accretion history of large ribosomal subunits deduced from theoretical minimal RNA rings is congruent with histories derived from phylogenetic and structural methods.
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DOI: 10.1016/j.gene.2020.144436
Abstract: Accretions of tRNAs presumably formed the large complex ribosomal RNA structures. Similarities of tRNA secondary structures with rRNA secondary structures increase with the integration order of their cognate amino acid in the genetic code, indicating… read more here.
Keywords: rna rings; secondary structures; rna; large ribosomal ... See more keywords
A minimal RNA ligand for potent RIG-I activation in living mice
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DOI: 10.1126/sciadv.1701854
Abstract: Short stem-loop RNAs activate RIG-I in mice, activating the innate immune system via specific patterns of gene expression. We have developed highly potent synthetic activators of the vertebrate immune system that specifically target the RIG-I… read more here.
Keywords: rig activation; rig; immune system; rna ligand ... See more keywords