Discovery of Tenapanor: A First-in-Class Minimally Systemic Inhibitor of Intestinal Na+/H+ Exchanger Isoform 3
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DOI: 10.1021/acsmedchemlett.2c00037
Abstract: We present herein the design, synthesis, and optimization of gut-restricted inhibitors of Na+/H+ exchanger isoform 3 (NHE3). NHE3 is predominantly expressed in the kidney and gastrointestinal tract where it acts as the major absorptive sodium… read more here.
Keywords: tenapanor first; exchanger isoform; first class; minimally systemic ... See more keywords