An allometric pharmacokinetic model and minimum effective analgesic concentration of fentanyl in patients undergoing major abdominal surgery.
Sign Up to like & getrecommendations! Published in 2020 at "British journal of anaesthesia"
DOI: 10.1016/j.bja.2020.06.066
Abstract: BACKGROUND We aimed to characterise the population pharmacokinetics of fentanyl in adults and to determine the minimum effective concentration (MEC) and minimum effective analgesic concentration (MEAC) of i.v. fentanyl in patients after major abdominal open… read more here.
Keywords: meac; minimum effective; model; concentration ... See more keywords
A two-stage Bayesian adaptive design for minimum effective dose (MinED)-based dosing-finding trials.
Sign Up to like & getrecommendations! Published in 2021 at "Contemporary clinical trials"
DOI: 10.1016/j.cct.2021.106504
Abstract: Conventional phase I designs for finding a phase II recommended dose (P2RD) based on toxicity alone is problematic because the maximum tolerated dose (MTD) is not necessarily the optimal dose. Instead, recently attention has been… read more here.
Keywords: two stage; dose mined; minimum effective; effective dose ... See more keywords
Minimum effective volume of ropivacaine for ultrasound-guided adductor canal + IPACK block in total knee arthroplasty: A double-blind, randomized dose-finding trial
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Orthopaedic Surgery"
DOI: 10.1177/10225536231161873
Abstract: Background Our previous study reported that when a respective 20 mL of ropivacaine was used for adductor canal block (ACB) combined with infiltration between the popliteal artery and capsule of the posterior knee (IPACK) block… read more here.
Keywords: minimum effective; volume; block; ipack block ... See more keywords