Genome Mining for Mycemycin: Discovery and Elucidation of Related Methylation and Chlorination Biosynthetic Chemistries.
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DOI: 10.1021/acs.orglett.8b03373
Abstract: A silent dibenzoxazepinone (DBP) biosynthetic gene cluster ( myc) was mutagenically activated in Streptomyces olivaceus SCSIO T05, enabling the discovery of mycemycin C (4) and three new analogues [mycemycins F-H (1-3)]. Gene disruption, complementation experiments,… read more here.
Keywords: mycemycin; discovery; mining mycemycin; genome mining ... See more keywords