Application of the Tissue Composition-Based Model to Minipig for Predicting the Volume of Distribution at Steady State and Dermis-to-Plasma Partition Coefficients of Drugs Used in the Physiologically Based Pharmacokinetics Model in Dermatology.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2018.09.001
Abstract: The minipig continues to build a reputation as a viable alternative large animal model to predict humans in dermatology and toxicology studies. Therefore, it is essential to describe and predict the pharmacokinetics in that species… read more here.
Keywords: dermatology; minipig; tissue; dermis ... See more keywords
Characterisation of intravenous pharmacokinetics in Göttingen minipig and clearance prediction using established in vitro to in vivo extrapolation methodologies
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DOI: 10.1080/00498254.2022.2115425
Abstract: Abstract The use of the Göttingen minipig as an animal model for drug safety testing and prediction of human pharmacokinetics (PK) continues to gain momentum in pharmaceutical research and development. The aim of this study… read more here.
Keywords: clearance; vivo; minipig; ttingen minipig ... See more keywords
EXTH-08. MINIPIG MODELS OF NEUROFIBROMATOSIS TYPE 1 FOR THERAPEUTIC DEVELOPMENT
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DOI: 10.1093/neuonc/noaa215.362
Abstract: Neurofibromatosis Type 1 (NF1) is a genetic disease caused by mutations in the neurofibromin 1 (NF1) gene. NF1 patients present with a variety of clinical manifestations and are predisposed to cancer development. Many NF1 animal… read more here.
Keywords: exth minipig; minipig; mek inhibitors; neurofibromatosis type ... See more keywords
From the Cover: The Minipig is a Suitable Non-Rodent Model in the Safety Assessment of Single Stranded Oligonucleotides
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DOI: 10.1093/toxsci/kfx025
Abstract: &NA; Non‐human primates (NHPs) are currently considered to be the non‐rodent species of choice for the preclinical safety assessment of single‐stranded oligonucleotide (SSO) drugs. We evaluated minipigs as a potential alternative to NHPs to test… read more here.
Keywords: assessment single; safety assessment; single stranded; safety ... See more keywords
Biochemical and Electroretinographic Characterization of the Minipig Eye in the Context of Drug Safety Investigations
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DOI: 10.1177/1091581819867929
Abstract: Minipigs are an emerging nonrodent alternative for ocular toxicology owing to anatomical similarities in the minipig eyes when compared to humans. Ocular structures and components from Göttingen minipigs were characterized and compared to species commonly… read more here.
Keywords: drug safety; characterization; toxicology; minipig ... See more keywords