Borylation of azines via a Minisci-type reaction
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DOI: 10.1016/j.chempr.2021.06.013
Abstract: C–H borylation of N-heteroarenes is an efficient yet highly challenging route to borylated aromatics. In a recent issue of Nature, Leonori and co-workers demonstrated a novel strategy toward this end by utilizing a boryl-radical-based Minisci-type… read more here.
Keywords: type reaction; borylation azines; minisci type;
Direct Minisci-Type C–H Amidation of Purine Bases
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DOI: 10.1021/acs.orglett.2c03206
Abstract: A method for the C–H carboxyamidation of purines has been developed that is capable of directly installing primary, secondary, and tertiary amides. Previous Minisci-type investigations on purines were limited to alkylations and arylations. Herein, we… read more here.
Keywords: minisci type; type amidation; direct minisci; type ... See more keywords
Photoredox-Mediated Minisci-type Alkylation of N-Heteroarenes with Alkanes with High Methylene Selectivity
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DOI: 10.1021/acscatal.8b04079
Abstract: We report a highly efficient and chemoselective Minisci-type alkylation reaction of N-heteroarenes with alkanes under the reagent control of a hypervalent iodine oxidant PFBI-OH. In addition to the high reactivity, PFBI-OH demonstrated a high steric… read more here.
Keywords: heteroarenes alkanes; minisci type; methylene; selectivity ... See more keywords
Recent Advances in Minisci-type Reactions and Applications in Organic Synthesis
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DOI: 10.2174/1385272824999201230211157
Abstract: Minisci-type reactions have been widely known as reactions that involve the addition of carbon-centered radicals to basic heteroarenes followed by formal hydrogen atom loss. While the originally developed protocols for radical generation remain in active… read more here.
Keywords: applications organic; organic synthesis; minisci type; generation ... See more keywords