Neuroinflammatory reactions in sickness behavior induced by bacterial infection: Protective effect of minocycline
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22020
Abstract: The neurological changes elicited by bacterial infection are called sickness behavior. Minocycline (MIN) is neuroprotective with a remarkable brain tissue penetration. MIN was orally administered at a dose 90 mg/kg for 3 days, whereas Escherichia… read more here.
Keywords: sickness behavior; minocycline; bacterial infection; infection ... See more keywords
Minocycline Promotes BDNF Expression of N2a Cells via Inhibition of miR-155-Mediated Repression After Oxygen-Glucose Deprivation and Reoxygenation
Sign Up to like & getrecommendations! Published in 2018 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-018-0599-0
Abstract: Minocycline, an anti-infective agent of a tetracycline derivative, is reported to improve behavioral functional recovery after cerebral ischemia via enhancing the levels of brain-derived neurotrophic factor (BDNF). However, the precise mechanisms that minocycline targets to… read more here.
Keywords: minocycline; mir 155; expression; oxygen glucose ... See more keywords
Minocycline attenuates neurological impairment and regulates iron metabolism in a rat model of traumatic brain injury.
Sign Up to like & getrecommendations! Published in 2020 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2020.108302
Abstract: There is currently no effective treatment for neurological impairment caused by traumatic brain injury (TBI). It has been reported that excessive iron production in the brain may be a key factor in neurological impairment. In… read more here.
Keywords: minocycline; iron metabolism; impairment; brain ... See more keywords
Minocycline enhances the mesenchymal stromal/stem cell pro-healing phenotype in triple antimicrobial-loaded hydrogels.
Sign Up to like & getrecommendations! Published in 2017 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2017.01.021
Abstract: Mesenchymal stromal/stem cells (MSCs) have demonstrated pro-healing properties including an anti-inflammatory cytokine profile and the promotion of angiogenesis via expression of growth factors in pre-clinical models. MSCs encapsulated in poly(ethylene glycol) diacrylate (PEGdA) and thiolated… read more here.
Keywords: minocycline; stromal stem; wound healing; mesenchymal stromal ... See more keywords
Minocycline alleviates depression-like symptoms by rescuing decrease in neurogenesis in dorsal hippocampus via blocking microglia activation/phagocytosis
Sign Up to like & getrecommendations! Published in 2021 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2020.11.009
Abstract: Clinical studies examining the potential of anti-inflammatory agents, specifically of minocycline, as a treatment for depression has shown promising results. However, mechanistic insights into the neuroprotective and anti-inflammatory actions of minocycline need to be provided.… read more here.
Keywords: minocycline; depression; neurogenesis; microglia activation ... See more keywords
Minocycline alleviates Gulf War Illness rats via altering gut microbiome, attenuating neuroinflammation and enhancing hippocampal neurogenesis
Sign Up to like & getrecommendations! Published in 2021 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2021.113366
Abstract: Accumulating evidences suggest that deficits in neurogenesis, chronic inflammation and gut microbiome dysregulation contribute to the pathophysiology of Gulf War Illness (GWI). Minocycline has been demonstrated to be a potent neuroprotective agent and could regulate… read more here.
Keywords: minocycline; hippocampal neurogenesis; treatment; neuroinflammation ... See more keywords
Minocycline inhibits sleep deprivation-induced aberrant microglial activation and Keap1-Nrf2 expression in mouse hippocampus
Sign Up to like & getrecommendations! Published in 2021 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2021.05.028
Abstract: Sleep deprivation (SD) is a hallmark of modern society and associated with many neuropsychiatric disorders, including depression and anxiety. However, the cellular and molecular mechanisms underlying SD-associated depression and anxiety remain elusive. Does the neuroinflammation… read more here.
Keywords: minocycline; sleep deprivation; activation keap1; keap1 nrf2 ... See more keywords
Protective effect of minocycline on LPS-induced mitochondrial dysfunction and decreased seizure threshold through nitric oxide pathway.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2019.172446
Abstract: Lipopolysaccharide (LPS) increases inflammatory cytokines of the brain and deregulates the mitochondrial function, thus could increase the seizure susceptibility. Studies have shown that minocycline has neuroprotective and antioxidant properties. In this study, we aimed to… read more here.
Keywords: minocycline; seizure threshold; lps treated; effect ... See more keywords
Amelioration of the apoptosis-mediated death in isolated human pancreatic islets by minocycline.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2019.172518
Abstract: Minocycline functions as a therapeutic drug in different diseases because of its cytoprotective properties. In the present study, we examined the potential of minocycline to decrease the islet loss in pre-transplantation culture stage. Pancreatic islets… read more here.
Keywords: minocycline; apoptosis mediated; death; amelioration apoptosis ... See more keywords
Reconnoitering the transformative journey of minocycline from an antibiotic to an antiepileptic drug.
Sign Up to like & getrecommendations! Published in 2022 at "Life sciences"
DOI: 10.1016/j.lfs.2022.120346
Abstract: Minocycline, a second-generation tetracycline antibiotic is being widely tested in animals as well as clinical settings for the management of multiple neurological disorders. The drug has shown to exert protective action in a multitude of… read more here.
Keywords: neurological disorders; journey minocycline; reconnoitering transformative; transformative journey ... See more keywords
In vitro synergistic effect of minocycline combined with antifungals against Cryptococcus neoformans.
Sign Up to like & getrecommendations! Published in 2021 at "Journal de mycologie medicale"
DOI: 10.1016/j.mycmed.2021.101227
Abstract: BACKGROUND Cryptococcus neoformans infections occur in immunocompromised patients, especially those with HIV infection, chemoradiotherapy after cancer, and organ transplantation. Infection can cause pneumonia and meningoencephalitis in severe cases with a high mortality rate if not… read more here.
Keywords: minocycline combined; minocycline; cryptococcus neoformans; voriconazole posaconazole ... See more keywords