Effects of suppressed bone remodeling by minodronic acid and alendronate on bone mass, microdamage accumulation, collagen crosslinks and bone mechanical properties in the lumbar vertebra of ovariectomized cynomolgus monkeys.
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DOI: 10.1016/j.bone.2017.01.008
Abstract: Collagen crosslinking is an important determinant of the quality of bone material. We have previously shown that suppressed bone turnover by high doses of minodronic acid and alendronate increases compressive strength of vertebra, but also… read more here.
Keywords: bone; minodronic acid; microdamage; acid alendronate ... See more keywords
Efficacy and safety of minodronic acid hydrate in patients with steroidâinduced osteoporosis
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DOI: 10.1111/1756-185x.12844
Abstract: Minodronic acid hydrate, an oral bisphosphonate, has a greater inhibitory effect on bone resorption than do other approved drugs; however, this has been studied only in patients with primary osteoporosis. Here, we administered minodronic acid… read more here.
Keywords: patients steroid; minodronic acid; hydrate patients; acid hydrate ... See more keywords
Identification, characterization, and determination of process-related impurities in Minodronic Acid bulk drug
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DOI: 10.2174/1573412917666210604160621
Abstract: Minodronic acid (MA) is a third-generation nitrogen-containing heterocyclic bisphosphonate used to treat osteoporosis. In the process of starting materials research and preparation, the key intermediate impurities and degradation impurities have a great impact on the… read more here.
Keywords: impurities minodronic; minodronic acid; related impurities; acid bulk ... See more keywords