Accumulation of minor alleles and risk prediction in schizophrenia
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DOI: 10.1038/s41598-017-12104-0
Abstract: Schizophrenia is a common neuropsychiatric disorder with a lifetime risk of 1%. Accumulation of common polygenic variations has been found to be an important risk factor. Recent studies showed a role for the enrichment of… read more here.
Keywords: accumulation; risk; schizophrenia; minor alleles ... See more keywords
APOE ɛ4 allele and TOMM40‐APOC1 variants jointly contribute to survival to older ages
Sign Up to like & getrecommendations! Published in 2022 at "Aging Cell"
DOI: 10.1111/acel.13730
Abstract: Age‐related diseases characteristic of post‐reproductive life, aging, and life span are the examples of polygenic non‐Mendelian traits with intricate genetic architectures. Polygenicity of these traits implies that multiple variants can impact their risks independently or… read more here.
Keywords: survival older; tomm40; carriers minor; older ages ... See more keywords
Circulating protein Z concentration, PROZ variants, and unexplained cerebral infarction in young and middle-aged adults.
Sign Up to like & getrecommendations! Published in 2017 at "Thrombosis and haemostasis"
DOI: 10.1160/th16-04-0277
Abstract: Protein Z (PZ) is a vitamin K-dependent plasma protein that exhibits both pro- and anticoagulant properties. Both low and high PZ levels have been linked to ischaemic stroke. Although PZ-lowering gene variants have been found… read more here.
Keywords: aged adults; minor alleles; middle aged; young middle ... See more keywords
Are minor alleles more likely to be risk alleles?
Sign Up to like & getrecommendations! Published in 2018 at "BMC Medical Genomics"
DOI: 10.1186/s12920-018-0322-5
Abstract: BackgroundGenome-wide association studies (GWASs) have revealed relationships between over 57,000 genetic variants and diseases. However, unlike Mendelian diseases, complex diseases arise from the interplay of multiple genetic and environmental factors. Natural selection has led to… read more here.
Keywords: risk alleles; risk; likely risk; risk allele ... See more keywords
Influence of Insulin Receptor Single Nucleotide Polymorphisms on Glycaemic Control and Formation of Anti-Insulin Antibodies in Diabetes Mellitus
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DOI: 10.3390/ijms23126481
Abstract: Single nucleotide polymorphisms (SNPs) in insulin and insulin receptor genes may influence the interaction between the two molecules, as may anti-insulin antibodies (IAs), commonly found in patients with type 1 diabetes mellitus (T1D) or type… read more here.
Keywords: minor alleles; glycaemic control; diabetes mellitus; insulin receptor ... See more keywords
Peptidylarginine Deiminase 2 Gene Polymorphisms in Subjects with Periodontitis Predispose to Rheumatoid Arthritis
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23179536
Abstract: Epidemiologic studies have shown associations between periodontitis and rheumatoid arthritis (RA), but a causal relationship has not been established. Citrullination of gingival proteins by human peptidylarginine deiminases (PADs) or PAD from Porphyromonas gingivalis has been… read more here.
Keywords: subjects periodontitis; increased risk; anti ccp; minor alleles ... See more keywords