Design, Synthesis, and Evaluation of Bis‐Benzothiazole Derivatives as DNA Minor Groove Binding Agents
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Heterocyclic Chemistry"
DOI: 10.1002/jhet.3041
Abstract: A series of novel bis-benzothiazole derivatives with head-to-head orientation were designed, synthesized, and evaluated for their anti-proliferative activities on U937, HL60, and HeLa cells. A significant part of the targets exhibited considerable in vitro anticancer… read more here.
Keywords: design synthesis; bis benzothiazole; minor groove; benzothiazole derivatives ... See more keywords
The Helix Twist: Damage and Repair Follows the DNA Minor Groove
Sign Up to like & getrecommendations! Published in 2018 at "Cell"
DOI: 10.1016/j.cell.2018.10.034
Abstract: Mutation frequencies vary along the genome, but the factors determining this variability are only partially understood. Pich et al. unravel a ∼10 bp periodicity in mutation rates at nucleosome-proximal regions that follows minor groove orientation. Opposing differential… read more here.
Keywords: minor groove; helix twist; damage repair;
Conformational properties of DNA minor groove binder Hoechst 33258 in gas phase and in aqueous solution
Sign Up to like & getrecommendations! Published in 2017 at "Computational and Theoretical Chemistry"
DOI: 10.1016/j.comptc.2017.05.006
Abstract: Abstract Drugs which are capable of targeting sequence specific DNA constitute a novel approach to chemotherapy and have been exploited in detail in recent years. In this context, the synthetic minor groove binder Hoechst 33258… read more here.
Keywords: minor groove; gas phase; groove binder; hoechst 33258 ... See more keywords
β-amino alcohols and their respective 2-phenyl-N-alkyl aziridines as potential DNA minor groove binders.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.07.055
Abstract: It is known that aziridines and nitrogen mustards exert their biological activities, especially in chemotherapy, via DNA alkylation. The studied scaffold, 2-phenyl-1-aziridine, provides a distinct conformation compared to commonly used aziridines, and therefore, leads to… read more here.
Keywords: dna; alcohols respective; minor groove; amino alcohols ... See more keywords
DNA Minor Groove-Induced cis-trans Isomerization of a Near-Infrared Fluorescent Probe.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemistry"
DOI: 10.1021/acs.biochem.1c00281
Abstract: The discovery of small molecules that exhibit turn-on far-red or near-infrared (NIR) fluorescence upon DNA binding and understanding how they bind DNA are important for imaging and bioanalytical applications. Here we report the DNA-bound structure… read more here.
Keywords: probe; dna; minor groove; trans isomerization ... See more keywords
Novel Pyridazin-3(2H)-one-Based Guanidine Derivatives as Potential DNA Minor Groove Binders with Anticancer Activity
Sign Up to like & getrecommendations! Published in 2022 at "ACS Medicinal Chemistry Letters"
DOI: 10.1021/acsmedchemlett.1c00633
Abstract: Novel aryl guanidinium analogues containing the pyridazin-3(2H)-one core were proposed as minor groove binders (MGBs) with the support of molecular docking studies. The target dicationic or monocationic compounds, which show the guanidium group at different… read more here.
Keywords: one based; guanidine; pyridazin one; minor groove ... See more keywords
Titanium dioxide nanoparticles preferentially bind in subdomains IB, IIA of HSA and minor groove of DNA
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2017.1361339
Abstract: Titanium dioxide nanoparticles (TiO2-NPs) interaction with human serum albumin (HSA) and DNA was studied by UV–visible spectroscopy, spectrofluorescence, circular dichroism (CD), and transmission electron microscopy (TEM) to analyze the binding parameters and protein corona formation.… read more here.
Keywords: dna; titanium dioxide; hsa; tio2 nps ... See more keywords
Capecitabine as a minor groove binder of DNA: molecular docking, molecular dynamics, and multi-spectroscopic studies
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2018.1461137
Abstract: The interaction mechanism and binding mode of capecitabine with ctDNA was extensively investigated using docking and molecular dynamics simulations, fluorescence and circular dichroism (CD) spectroscopy, DNA thermal denaturation studies, and viscosity measurements. The possible binding… read more here.
Keywords: molecular dynamics; dna; docking molecular; capecitabine ... See more keywords
Identification of a 3-(5-methyl-2-thiazolylamino)phthalide as a new minor groove agent
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2022.2061595
Abstract: Abstract A new 3-(5-methyl-2-thiazolylamino)phthalide molecule, 3-((5-methylthiazol-2-yl)amino)isobenzofuran-1(3H)-one, was synthesized and characterized experimentally by FT-IR, NMR, UV-Vis, and single-crystal X-ray analysis and theoretically by quantum chemical calculations. The single-crystal X-ray studies revealed that the compound crystallizes in… read more here.
Keywords: groove; minor groove; thiazolylamino phthalide; methyl thiazolylamino ... See more keywords
Evaluation of minor groove binders (MGBs) as novel anti-mycobacterial agents and the effect of using non-ionic surfactant vesicles as a delivery system to improve their efficacy
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Antimicrobial Chemotherapy"
DOI: 10.1093/jac/dkx326
Abstract: Objectives The slow development of major advances in drug discovery for the treatment of Mycobacterium tuberculosis (Mtb) infection suggests a compelling need for evaluation of more effective drug therapies against TB. New classes of drugs… read more here.
Keywords: anti mycobacterial; minor groove; evaluation; binders mgbs ... See more keywords
Four pyrrole derivatives used as building blocks in the synthesis of minor-groove binders
Sign Up to like & getrecommendations! Published in 2017 at "Acta Crystallographica Section E: Crystallographic Communications"
DOI: 10.1107/s2056989017001177
Abstract: The title nitropyrrole-based compounds are intermediates used in the synthesis of modified DNA minor-groove binders. They are ethyl 4-nitro-1H-pyrrole-2-carboxylate, its derivative ethyl 4-nitro-1-(4-pentynyl)-1H-pyrrole-2-carboxylate, N-[3-(dimethylamino)propyl]-1-isopentyl-4-nitro-1H-pyrrole-2-carboxamide and 1-(3-azidopropyl)-4-(1-methyl-4-nitro-1H-pyrrole-2-carboxamido)-N-[2-(morpholin-4-yl)ethyl]-1H-pyrrole-2-carboxamide. read more here.
Keywords: pyrrole; nitro pyrrole; minor groove; groove binders ... See more keywords