P028 Immunogenicity of minor histocompatibility antigens may be dependent on the frequencies of naive precursor cells in the donor repertoire
Sign Up to like & getrecommendations! Published in 2017 at "Human Immunology"
DOI: 10.1016/j.humimm.2017.06.088
Abstract: Aim Out of 60+ minor histocompatibility antigens (MiHA) discovered so far some are immunodominant, i.e. almost universally cause allogeneic response when mismatched, while others are much less immunogenic. Before transplantation MiHA specific T cells reside… read more here.
Keywords: immunogenicity; histocompatibility antigens; minor histocompatibility; miha ... See more keywords
Shared graft-versus-leukemia minor histocompatibility antigens in DISCOVeRY-BMT
Sign Up to like & getrecommendations! Published in 2022 at "Blood Advances"
DOI: 10.1101/2022.08.12.503667
Abstract: T cell responses to minor histocompatibility antigens (mHAs) mediate graft versus leukemia (GvL) effects and graft versus host disease (GvHD) in allogeneic hematopoietic cell transplant (alloHCT). Therapies that boost T cell responses improve the efficacy… read more here.
Keywords: minor histocompatibility; graft versus; discovery bmt; gvl ... See more keywords
Towards Predicting Graft Vs Host Disease from Predicted Tissue Specific Minor Histocompatibility Antigens
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-119783
Abstract: Graft versus host disease (GVHD) continues to be a life-threatening complication of stem cell transplantation for hematological malignancies. GVHD occurs in perfectly HLA-matched, related (MRD) transplants, and conversely can be absent in matched un-related (MUD)… read more here.
Keywords: histocompatibility antigens; mha; tissue; minor histocompatibility ... See more keywords
Development of T-Cell Therapy Targeting Hematopoietic Minor Histocompatibility Antigen HA-1
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood-2019-130552
Abstract: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is currently the only curative therapy for hematological malignancies yet in nearly one-third of patients, it is followed by a relapse of the disease contributing to high mortality. In… read more here.
Keywords: minor histocompatibility; therapy; tcrs; cell ... See more keywords
Computational modeling and confirmation of leukemia-associated minor histocompatibility antigens.
Sign Up to like & getrecommendations! Published in 2018 at "Blood advances"
DOI: 10.1182/bloodadvances.2018022475
Abstract: T-cell responses to minor histocompatibility antigens (mHAs) mediate both antitumor immunity (graft-versus-leukemia [GVL]) and graft-versus-host disease (GVHD) in allogeneic stem cell transplant. Identifying mHAs with high allele frequency, tight binding affinity to common HLA molecules,… read more here.
Keywords: leukemia associated; histocompatibility antigens; antigen; minor histocompatibility ... See more keywords
In Silico Analysis of the Minor Histocompatibility Antigen Landscape Based on the 1000 Genomes Project
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.01819
Abstract: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is routinely used to treat hematopoietic malignancies. The eradication of residual tumor cells during engraftment is mediated by donor cytotoxic T lymphocytes reactive to alloantigens. In a HLA-matched transplantation… read more here.
Keywords: silico analysis; landscape; hla; transplantation ... See more keywords