MINPP1 prevents intracellular accumulation of the chelator inositol hexakisphosphate and is mutated in Pontocerebellar Hypoplasia
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DOI: 10.1038/s41467-020-19919-y
Abstract: Inositol polyphosphates are vital metabolic and secondary messengers, involved in diverse cellular functions. Therefore, tight regulation of inositol polyphosphate metabolism is essential for proper cell physiology. Here, we describe an early-onset neurodegenerative syndrome caused by… read more here.
Keywords: inositol; accumulation; inositol hexakisphosphate; minpp1 ... See more keywords
Stable Isotopomers of myo-Inositol Uncover a Complex MINPP1-Dependent Inositol Phosphate Network
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DOI: 10.1101/2022.08.29.505671
Abstract: The water-soluble inositol phosphates (InsPs) represent a functionally diverse group of small-molecule messengers central to a myriad of cellular processes. However, we have an incomplete understanding of InsP metabolism because the available analytical toolset for… read more here.
Keywords: inositol; minpp1; inositol phosphates; stable isotopomers ... See more keywords
Multiple Inositol Polyphosphate Phosphatase Compartmentalization Separates Inositol Phosphate Metabolism from Inositol Lipid Signaling
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DOI: 10.3390/biom13060885
Abstract: Multiple inositol polyphosphate phosphatase (MINPP1) is an enigmatic enzyme that is responsible for the metabolism of inositol hexakisphosphate (InsP6) and inositol 1,3,4,5,6 pentakisphosphate (Ins(1,3,4,5,6)P5 in mammalian cells, despite being restricted to the confines of the… read more here.
Keywords: inositol; minpp1; phosphatase; metabolism inositol ... See more keywords