Pharmacological inhibition of Mint3 attenuates tumour growth, metastasis, and endotoxic shock
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DOI: 10.1038/s42003-021-02701-1
Abstract: Hypoxia-inducible factor-1 (HIF-1) plays essential roles in human diseases, though its central role in oxygen homoeostasis hinders the development of direct HIF-1-targeted pharmacological approaches. Here, we surveyed small-molecule compounds that efficiently inhibit the transcriptional activity… read more here.
Keywords: hif; mint3; tumour growth; endotoxic shock ... See more keywords