Clock Gene Dysregulation Induced by Chronic ER Stress Disrupts β-cell Function
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DOI: 10.1016/j.ebiom.2017.03.040
Abstract: In Wfs1−/−Ay/a islets, in association with endoplasmic reticulum (ER) stress, D-site-binding protein (Dbp) expression decreased and Nuclear Factor IL-3 (Nfil3)/E4 Promoter-binding protein 4 (E4bp4) expression increased, leading to reduced DBP transcriptional activity. Similar alterations were… read more here.
Keywords: clock gene; gene dysregulation; stress; gene ... See more keywords