Exosomal microRNAs as tumor markers in epithelial ovarian cancer
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12371
Abstract: Specific microRNAs (miRNAs) are packaged in exosomes that regulate processes in tumor development and progression. The current study focuses on the influence of exosomal miRNAs in the pathogenesis of epithelial ovarian cancer (EOC). MiRNA profiles… read more here.
Keywords: epithelial ovarian; mir; mir 200b; ovarian cancer ... See more keywords
Homocysteine induces podocyte apoptosis by regulating miR-1929-5p expression through c-Myc, DNMT1 and EZH2.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular oncology"
DOI: 10.1002/1878-0261.13032
Abstract: Chronic kidney disease (CKD) is a common and complex disease in kidneys which has been associated with an increased risk of renal cell carcinoma (RCC). Elevated homocysteine (Hcy) levels are known to influence the development… read more here.
Keywords: apoptosis; mir; 1929 expression; dnmt1 ezh2 ... See more keywords
MiR‐17‐3p inhibits osteoblast differentiation by downregulating Sox6 expression
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12979
Abstract: Osteoporosis and osteoarthritis are orthopedic disorders that affect millions of elderly people worldwide; stimulation of bone formation is a potential therapeutic strategy for the treatment of these conditions. As the only bone‐forming cells, osteoblasts play… read more here.
Keywords: mir; differentiation; role; osteoblast differentiation ... See more keywords
Identification of modules and novel prognostic biomarkers in liver cancer through integrated bioinformatics analysis
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DOI: 10.1002/2211-5463.12983
Abstract: Liver cancer is a common malignant tumor with poor prognosis. Due to the lack of specific clinical manifestations at early stages, most patients are already at advanced stages of the disease by the time of… read more here.
Keywords: biomarkers liver; analysis; mir; prognostic biomarkers ... See more keywords
Targeting of ΔNp63α by miR‐522 promotes the migration of breast epithelial cells
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DOI: 10.1002/2211-5463.13072
Abstract: The TP63 gene, which encodes the p63 protein, is involved in multiple biological processes, including embryonic development and tumorigenesis. ΔNp63α, the predominant isoform of p63 in epithelial cells, acts as an oncogene in early‐stage tumors,… read more here.
Keywords: epithelial cells; breast epithelial; mir; targeting np63 ... See more keywords
Inhibition of miR‐93‐5p promotes osteogenic differentiation in a rabbit model of trauma‐induced osteonecrosis of the femoral head
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DOI: 10.1002/2211-5463.13218
Abstract: Trauma‐induced osteonecrosis of the femoral head (TIONFH) is characterized by femoral head collapse accompanied by degenerative changes of the hip. We previously reported that miR‐93‐5p expression is abnormally high in patients with TIONFH, but the… read more here.
Keywords: femoral head; mir; expression; rabbit model ... See more keywords
Inflammation‐Instructed Hierarchical Delivery of IL‐4/miR‐21 Orchestrates Osteoimmune Microenvironment toward the Treatment of Rheumatoid Arthritis
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DOI: 10.1002/adfm.202101033
Abstract: Dysregulated inflammation and failure in resolution account for the incidence and deterioration of rheumatoid arthritis (RA). IL‐4 and miR‐21 possess complementary functions in inhibiting inflammation and fostering resolution. Thus, inflammation‐instructed nanocomplexes (NCs) are herein developed… read more here.
Keywords: arthritis; mir; delivery mir; microenvironment ... See more keywords
Combined serum miR‐29c and miR‐149 expression analysis as diagnostic genetic markers for colorectal cancer
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology and Applied Biochemistry"
DOI: 10.1002/bab.1986
Abstract: Circulating miRNAs gathered much interest in cancer research as noninvasive biomarkers. The aim of this study was to analyze the expression of miR‐29c and miR‐149 among colorectal cancer (CRC) patients and to explore their diagnostic… read more here.
Keywords: mir 149; mir; expression; cancer ... See more keywords
Inhibition of endogenous miR‐23a/miR‐377 in CHO cells enhances difficult‐to‐express recombinant lysosomal sulfatase activity
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology Progress"
DOI: 10.1002/btpr.2974
Abstract: Difficult‐to‐express (DTE) recombinant proteins such as multi‐specific proteins, DTE monoclonal antibodies, and lysosomal enzymes have seen difficulties in manufacturability using Chinese hamster ovary (CHO) cells or other mammalian cells as production platforms. CHO cells are… read more here.
Keywords: mir 23a; sulfatase; cho cells; mir ... See more keywords
MiR‐5683 suppresses glycolysis and proliferation through targeting pyruvate dehydrogenase kinase 4 in gastric cancer
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DOI: 10.1002/cam4.3344
Abstract: Gastric cancer (GC) is one of the most deadly malignancies at global scale, and is particularly common in eastern Asia. MicroRNA‐5683 (miR‐5683) was confirmed to be downregulated in GC by analyzing data from the Cancer… read more here.
Keywords: glycolysis; mir 5683; gastric cancer; mir ... See more keywords
Association between miR‐146a rs2910164, miR‐196a2 rs11614913, and miR‐499 rs3746444 polymorphisms and the risk of esophageal carcinoma: A case–control study
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.4729
Abstract: MicroRNAs (miRNAs) are a group of small, non‐coding, and endogenous RNAs that regulate gene expression and over 50% of them are located at cancer‐related genomic regions or fragile sites. According to previous studies there is… read more here.
Keywords: rs2910164; risk; association; mir ... See more keywords