Tumor‐suppressive microRNA‐10a inhibits cell proliferation and metastasis by targeting Tiam1 in esophageal squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28059
Abstract: Aberrant microRNAs (miRNAs) expressions could contribute to the progression of numerous cancers, including esophageal squamous cell carcinoma, while miR‐10a participates in multiple biological processes on cancers. However, the molecular mechanism of miR‐10a in esophageal squamous… read more here.
Keywords: esophageal squamous; cell carcinoma; squamous cell; mir 10a ... See more keywords
S-equol inhibits proliferation and promotes apoptosis of human breast cancer MCF-7 cells via regulating miR-10a-5p and PI3K/AKT pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2019.108064
Abstract: S-equol is the exclusive enantiomeric form of the soy isoflavone metabolite produced by human intestinal bacterial flora, which has strong anti-cancer activity. Based on this, the purpose of this study was to investigate the anti-breast… read more here.
Keywords: cancer; mir 10a; mcf cells; breast cancer ... See more keywords
MicroRNA-10a-3p mediates Th17/Treg cell balance and improves renal injury by inhibiting REG3A in lupus nephritis.
Sign Up to like & getrecommendations! Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.106891
Abstract: BACKGROUND The therapeutic approaches guided toward microRNAs (miRNAs) have been extensively explored in lupus nephritis (LN), but the precise position of miR-10a-3p posted in disease is not translated thoroughly. Therein, this work pivoting on miR-10a-3p… read more here.
Keywords: th17 treg; reg3a; renal injury; mir 10a ... See more keywords
Targeting miR-10a-5p/IL-6R axis for reducing IL-6-induced cartilage cell ferroptosis.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental and molecular pathology"
DOI: 10.1016/j.yexmp.2020.104570
Abstract: BACKGROUND Intervertebral disc degeneration (IDD) causes lower back pain, and is often accompanied with robust inflammation. However, whether inflammation plays a role in IDD remains controversial, and the mechanism is ill-elucidated. METHODS Cartilage specimens from… read more here.
Keywords: mir 10a; cell ferroptosis; cartilage cell; cartilage ... See more keywords
XRN2 promotes EMT and metastasis through regulating maturation of miR-10a
Sign Up to like & getrecommendations! Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2017.39
Abstract: MicroRNAs (miRNAs) have been proposed as critical regulatory molecules in the epithelial–mesenchymal transition (EMT) program. However, the roles of mature miRNA biogenesis during EMT process needs to be defined. Here we determined that increased expression… read more here.
Keywords: xrn2; metastasis; xrn2 promotes; promotes emt ... See more keywords
Down-regulation of miR-10a-5p promotes proliferation and restricts apoptosis via targeting T-box transcription factor 5 in inflamed synoviocytes
Sign Up to like & getrecommendations! Published in 2018 at "Bioscience Reports"
DOI: 10.1042/bsr20180003
Abstract: Synoviocytes from rheumatoid arthritis (RA) patients share certain features with tumor cells, such as over proliferation and invasion. Anomalous microRNA (miRNA) expression may participate in the pathogenesis of RA in different ways. The objective of… read more here.
Keywords: tbx5; apoptosis; proliferation; mir 10a ... See more keywords
Modulation of miR-10a-mediated TGF-β1/Smads signaling affects atrial fibrillation-induced cardiac fibrosis and cardiac fibroblast proliferation
Sign Up to like & getrecommendations! Published in 2019 at "Bioscience Reports"
DOI: 10.1042/bsr20181931
Abstract: Atrial fibrillation (AF) rat models and rat cardiac fibroblasts (CFs) with overexpressed or inhibited miR-10a were used to investigate the possible role of miR-10a-mediated transforming growth factor-β (TGF-β1)/Smads signaling in cardiac fibrosis and fibroblast proliferation… read more here.
Keywords: tgf; cardiac fibrosis; mir 10a; proliferation ... See more keywords
A potential risk factor of essential hypertension in case-control study: MicroRNAs miR-10a-5p
Sign Up to like & getrecommendations! Published in 2019 at "Clinical and Experimental Hypertension"
DOI: 10.1080/10641963.2019.1571597
Abstract: ABSTRACT Background: Essential hypertension is a multifactorial disease with high morbidity. The researches on the influence of genes on the disease are still in its infancy, and the mechanism of gene regulation is not clear.… read more here.
Keywords: control; hypertension; risk factor; mir 10a ... See more keywords
Long non-coding RNA LINRIS is upregulated in non-small cell lung cancer and its silencing inhibits cell proliferation by suppressing microRNA-10a maturation
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2031672
Abstract: ABSTRACT Long noncoding RNA LINRIS (LINC00920) is known to participate in colorectal cancer. This study aimed to explore the role of LINRIS in non-small cell lung cancer (NSCLC). NSCLC and adjacent non-tumor tissues were collected… read more here.
Keywords: cell; cell proliferation; linris; mir 10a ... See more keywords
LncRNA MIR22HG inhibits growth, migration and invasion through regulating the miR‐10a‐5p/NCOR2 axis in hepatocellular carcinoma cells
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Science"
DOI: 10.1111/cas.13950
Abstract: Despite the rapidly identified numbers of lncRNA in humans, exploration of the molecular mechanisms of lncRNA is lagging, because the molecular mechanisms of lncRNA can be various and complex in different conditions. In this study,… read more here.
Keywords: hepatocellular carcinoma; hcc; mir 10a; mir22hg ... See more keywords
Host Cells Actively Resist Porcine Reproductive and Respiratory Syndrome Virus Infection via the IRF8-MicroRNA-10a-SRP14 Regulatory Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.00003-22
Abstract: Porcine reproductive and respiratory syndrome virus (PRRSV) has rapidly spread to the global pig industry and caused incalculable economic damage since first discovered in the 1980s. However, conventional vaccines do not provide satisfactory protection. ABSTRACT… read more here.
Keywords: prrsv infection; irf8; mir 10a; infection ... See more keywords