Exosome‐delivered circRNA promotes glycolysis to induce chemoresistance through the miR‐122‐PKM2 axis in colorectal cancer
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12629
Abstract: Malignant tumors, including colorectal cancer (CRC), usually rely on ATP generation through aerobic glycolysis for both rapid growth and chemotherapy resistance. The M2 isoform of pyruvate kinase (PKM2) has a key role in catalyzing glycolysis,… read more here.
Keywords: glycolysis; pkm2; colorectal cancer; 122 pkm2 ... See more keywords
Overexpression of miR-122 promotes apoptosis of dermal papilla cells by directly targeting IGF1R in androgenetic alopecia.
Sign Up to like & getrecommendations! Published in 2021 at "Cell biology international"
DOI: 10.1002/cbin.11723
Abstract: Androgenetic alopecia (AGA) is the most common pattern of hair loss resulting from the effects of androgen on hair follicle. MicroRNAs (miRs) serve imperative roles in the regulation of many biological processes of hair follicle.… read more here.
Keywords: papilla cells; dermal papilla; mir 122; androgenetic alopecia ... See more keywords
Apigenin inhibits isoproterenol‐induced myocardial fibrosis and Smad pathway in mice by regulating oxidative stress and miR‐122‐5p/155‐5p expressions
Sign Up to like & getrecommendations! Published in 2022 at "Drug Development Research"
DOI: 10.1002/ddr.21928
Abstract: Apigenin, a flavonoid isolated from Apium graveolens, is an effective natural active ingredient that inhibits transforming growth factor‐β1 (TGF‐β1)‐induced cardiac fibroblasts (CFs) differentiation and collagen synthesis. However, its effects on isoproterenol‐induced myocardial fibrosis in mice… read more here.
Keywords: apigenin; myocardial fibrosis; mir 122; mice ... See more keywords
miR‐122 promotes metastasis of clear‐cell renal cell carcinoma by downregulating Dicer
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Cancer"
DOI: 10.1002/ijc.31050
Abstract: Although overall downregulation of microRNAs (miRNAs) is a general feature of clear‐cell renal cell carcinoma (ccRCC), several miRNAs are consistently upregulated, among which miR‐122 was markedly increased in ccRCC tissues. Our study aims to determine… read more here.
Keywords: cell renal; ccrcc; dicer; mir 122 ... See more keywords
miR-122 and the WNT/β-catenin pathway inhibit effects of both interleukin-1β and tumor necrosis factor-α in articular chondrocytes in vitro.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of cellular biochemistry"
DOI: 10.1002/jcb.30244
Abstract: Interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), and WNT/β-catenin signaling cause dysregulation of rat primary articular chondrocytes (rArCs), resulting in cartilage extracellular matrix destruction and osteoarthritis (OA) progression. microRNA (miR) miR-122 represses these effects whereas miR-451… read more here.
Keywords: mmp pge2; mir 451; wnt catenin; pge2 production ... See more keywords
Clinical value of serum miR‐92 and miR‐122 expression level combined with pulmonary ultrasound score in the prognosis of neonatal acute respiratory distress syndrome
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24485
Abstract: To explore the value of the expression of serum miR‐92 and miR‐122 combined with lung ultrasound score (LUS) in the prognosis of neonatal acute respiratory distress syndrome (ARDS). read more here.
Keywords: serum mir; prognosis neonatal; mir 122; ultrasound score ... See more keywords
Circulating miR‐22‐5p and miR‐122‐5p are promising novel biomarkers for diagnosis of acute myocardial infarction
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27274
Abstract: This study sought to evaluate the potential of circulating microRNAs (miRNAs) as novel indicators for acute myocardial infarction (AMI). read more here.
Keywords: mir mir; myocardial infarction; circulating mir; mir 122 ... See more keywords
miR‐122‐5p promotes aggression and epithelial‐mesenchymal transition in triple‐negative breast cancer by suppressing charged multivesicular body protein 3 through mitogen‐activated protein kinase signaling
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29188
Abstract: Triple‐negative breast cancer (TNBC) is highly metastatic and frequently has a poor prognosis. The lack of comprehension of TNBC and gene therapy targets has led to limitedly effective treatment for TNBC. This study was conducted… read more here.
Keywords: chmp3 gene; gene; mir 122; breast cancer ... See more keywords
Circulating microRNA‐122 levels are important predictor of hepatitis B virus surface antigen seroclearance
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Medical Virology"
DOI: 10.1002/jmv.25238
Abstract: It is currently unclear what impact serum microRNA‐122 (miR‐122) levels have on clearance of hepatitis B virus (HBV) surface antigen (HBsAg) in HBV‐infected patients who had not received antiviral therapy. The current study evaluated the… read more here.
Keywords: antigen; mir 122; serum mir; seroclearance ... See more keywords
Exosomal miR‐122 promotes adipogenesis and aggravates obesity through the VDR/SREBF1 axis
Sign Up to like & getrecommendations! Published in 2022 at "Obesity"
DOI: 10.1002/oby.23365
Abstract: This study examined the effects of miR‐122–enriched exosomes on the expression of vitamin D3 receptor (VDR) and sterol regulatory element‐binding transcription factor 1 (SREBF1) and their roles during adipogenesis. read more here.
Keywords: 122 promotes; obesity; exosomal mir; vdr ... See more keywords
NEAT1 accelerates the progression of liver fibrosis via regulation of microRNA-122 and Kruppel-like factor 6
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Medicine"
DOI: 10.1007/s00109-017-1586-5
Abstract: Long non-coding RNAs (lncRNAs) have been reported to be involved in many important biological processes including proliferation, apoptosis, differentiation, and survival. Recently, nuclear paraspeckle assembly transcript 1 (NEAT1), a novel lncRNA, serves as a crucial… read more here.
Keywords: hsc activation; neat1; mir 122; liver fibrosis ... See more keywords