Kindlin-2–miR-1258–TCF4 feedback loop promotes hepatocellular carcinoma invasion and metastasis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Gastroenterology"
DOI: 10.1007/s00535-022-01866-8
Abstract: Upregulated Kindlin-2 expression in hepatocellular carcinoma (HCC) correlates with metastasis and poor prognosis. In this study, we investigated the molecular mechanism of Kindlin-2 in HCC. Kindlin-2 downstream pathways were explored through microRNA sequencing. The Kindlin-2–miR-1258–TCF4… read more here.
Keywords: expression; mir 1258; kindlin mir; kindlin ... See more keywords
MiR-1258 promotes the apoptosis of cervical cancer cells by regulating the E2F1/P53 signaling pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental and molecular pathology"
DOI: 10.1016/j.yexmp.2020.104368
Abstract: OBJECTIVE Cervical cancer is the most common malignant tumor in gynaecology with high mortality. MiRNA has been reported to regulate cell biological processes in cervical cancer. This study aimed to explore the expression of miR-1258… read more here.
Keywords: expression; mir 1258; cervical cancer; cancer cells ... See more keywords
Hsa_circ_0101432 promotes the development of hepatocellular carcinoma (HCC) by adsorbing miR-1258 and miR-622
Sign Up to like & getrecommendations! Published in 2019 at "Cell Cycle"
DOI: 10.1080/15384101.2019.1618120
Abstract: ABSTRACT The present research was major in investigating the regulation association among hsa_circ_0101432 (has_circ_RPPH1), miR-1258, miR-622 and MAPK1 in hepatocellular carcinoma (HCC), and we explored the mechanism underlying pathogenesis of HCC. Microarray analysis was employed… read more here.
Keywords: mir 1258; mir; mir 622; 1258 mir ... See more keywords
Astragalus polysaccharide regulates brown adipogenic differentiation through miR-1258-5p-modulated cut-like homeobox 1 expression.
Sign Up to like & getrecommendations! Published in 2021 at "Acta biochimica et biophysica Sinica"
DOI: 10.1093/abbs/gmab151
Abstract: Astragalus polysaccharide (APS) is the major natural active component of Astragalus membranaceus, which has been recognized as one of the most popular herbal medicines worldwide. Enhancing the formation and function of brown adipose tissue increases… read more here.
Keywords: brown adipogenic; mir 1258; adipogenic differentiation; differentiation ... See more keywords
Frequent methylation of the tumour suppressor miR‐1258 targeting PDL1: implication in multiple myeloma‐specific cytotoxicity and prognostification
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Haematology"
DOI: 10.1111/bjh.16517
Abstract: miR‐1258 is localised to the first intron of ZNF385B at chromosome 2q31.3. miR‐1258 promoter methylation was studied in 147 samples including 10 normal buffy coat, eight normal bone marrow plasma cells, 16 human myeloma cell… read more here.
Keywords: methylation; mir 1258; myeloma; mir ... See more keywords
Research progress on microRNA-1258 in the development of human cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.1024234
Abstract: microRNAs (miRNAs) are small endogenous RNAs composed of 20-22 nucleotides that do not encode proteins, which regulate the expression of downstream genes by targeting the 3’ untranslated region of mRNA. Plentiful research has demonstrated that… read more here.
Keywords: progress microrna; research; development; research progress ... See more keywords
Circular RNA CircCDKN2B−AS_006 Promotes the Tumor-like Growth and Metastasis of Rheumatoid Arthritis Synovial Fibroblasts by Targeting the miR−1258/RUNX1 Axis
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24065880
Abstract: Rheumatoid arthritis (RA) is an autoimmune polyarthritis in which synovial fibroblasts (SFs) play a major role in cartilage and bone destruction through tumor−like proliferation, migration, and invasion. Circular RNAs (circRNAs) have emerged as vital regulators… read more here.
Keywords: mir 1258; runx1; arthritis; circcdkn2b 006 ... See more keywords