Joint action of miR‐126 and MAPK/PI3K inhibitors against metastatic melanoma
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12506
Abstract: Emerging data support the rationale of combined therapies in advanced melanoma. Specifically, the combined use of drugs with different mechanisms of action can reduce the probability of selecting resistant clones. To identify agents active against… read more here.
Keywords: combination; mir 126; pik; metastatic melanoma ... See more keywords
Co-targeting of miR-126-3p and miR-221-3p inhibits PIK3R2 and PTEN, reducing lung cancer growth and metastasis by blocking AKT and CXCR4 signaling.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular oncology"
DOI: 10.1002/1878-0261.13036
Abstract: Lung cancer is the leading cause of cancer-related death worldwide. Late diagnosis and metastatic dissemination contribute to its low survival rate. Since microRNA (miRNA) deregulation triggers lung carcinogenesis, miRNAs might represent an interesting therapeutic tool… read more here.
Keywords: cancer; mir 221; mir 126; lung cancer ... See more keywords
miR‐126 downregulates CXCL12 expression in intestinal epithelial cells to suppress the recruitment and function of macrophages and tumorigenesis in a murine model of colitis‐associated colorectal cancer
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13218
Abstract: Inflammatory bowel disease, characterised by chronic relapsing‐remitting colitis, is a significant risk factor for colorectal cancer (CRC). Previously, we showed that miR‐126 functions as a tumour suppressor in CRC and is inversely correlated with tumour… read more here.
Keywords: colitis associated; colitis; colorectal cancer; mir 126 ... See more keywords
Physical Activity Modulates the Overexpression of the Inflammatory miR‐146a‐5p in Obese Patients
Sign Up to like & getrecommendations! Published in 2018 at "IUBMB Life"
DOI: 10.1002/iub.1926
Abstract: Specific microRNAs (miRs), including the “angio‐miR‐126” and the “inflamma‐miR‐146a‐5p,” have been proposed as biomarkers and even therapeutic targets of obesity‐associated metabolic diseases. Physical activity, a key measure of prevention for obesity and its complications, is… read more here.
Keywords: obese patients; physical activity; mir 146a; mir 126 ... See more keywords
MiR‐126 correlates with increased disease severity and promotes keratinocytes proliferation and inflammation while suppresses cells' apoptosis in psoriasis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.22588
Abstract: This study aimed to investigate the miR‐126 expression in lesional skin and its correlation with clinical features in psoriasis patients and to explore the effect of upregulated miR‐126 on cells' proliferation, apoptosis, and inflammation in… read more here.
Keywords: mir 126; increased disease; inflammation; correlates increased ... See more keywords
Mango polyphenolics reduce inflammation in intestinal colitis—involvement of the miR‐126/PI3K/AKT/mTOR axis in vitro and in vivo
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.22484
Abstract: This study sought to elucidate the mechanisms underlying the anti‐inflammatory effect of mango (Mangifera Indica L.) polyphenolics containing gallic acid and gallotanins, and the role of the miR‐126/PI3K/AKT/mTOR signaling axis in vitro and in vivo.… read more here.
Keywords: mir 126; akt mtor; pi3k akt; mango ... See more keywords
Senescence-associated miR-34a and miR-126 in middle-aged Indians with type 2 diabetes
Sign Up to like & getrecommendations! Published in 2019 at "Clinical and Experimental Medicine"
DOI: 10.1007/s10238-019-00593-4
Abstract: Rapid urbanization and unhealthy dietary patterns critically increase the risk of type 2 diabetes (T2D) in middle-aged Indians. However, despite recent evidence of senescence-associated microRNAs (SA-miRNAs) in regulating complex pathways of ageing, their expressions in middle-aged… read more here.
Keywords: mir 126; senescence associated; mir 34a; middle aged ... See more keywords
MircoRNA-126-5p inhibits apoptosis of endothelial cell in vascular arterial walls via NF-κB/PI3K/AKT/mTOR signaling pathway in atherosclerosis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Molecular Histology"
DOI: 10.1007/s10735-021-10041-x
Abstract: Atherosclerosis is considered as a chronic inflammatory disease. MircoRNA-126-5p (miR-126-5p) may be pathophysiological relevant with the apoptotic processes in the endothelial cells in the arterial wall. Here, this study determined the role of circulating atherosclerosis-regulatory miR-126-5p… read more here.
Keywords: akt mtor; mir 126; atherosclerosis; pi3k akt ... See more keywords
Overexpression of HOTAIR attenuates Pi-induced vascular calcification by inhibiting Wnt/β-catenin through regulating miR-126/Klotho/SIRT1 axis.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular and cellular biochemistry"
DOI: 10.1007/s11010-021-04164-8
Abstract: Vascular calcification is one of the most common effects of macrovascular complications in patients in aging with chronic kidney disease and diabetes. Previous studies showed that HOTAIR attenuated vascular calcification via the Wnt/β-catenin-signaling pathway, yet… read more here.
Keywords: vascular calcification; mir 126; hotair; calcification ... See more keywords
Exosomes Derived from Senescent Endothelial Cells Contain Distinct Pro-angiogenic miRNAs and Proteins.
Sign Up to like & getrecommendations! Published in 2022 at "Cardiovascular toxicology"
DOI: 10.1007/s12012-022-09740-y
Abstract: Exosomes from senescence cells play pivotal roles in endothelium dysfunction. We investigated the exosomal angiogenic cargo of endothelial cells (ECs) in a model of senescence in vitro. After inducing aging by H2O2, the expression of… read more here.
Keywords: expression; western blotting; mir 126; exosomes derived ... See more keywords
Hypoxic mesenchymal stem cell-derived exosomes promote bone fracture healing by the transfer of miR-126.
Sign Up to like & getrecommendations! Published in 2019 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2019.12.020
Abstract: Increasing evidence has suggested that paracrine mechanisms might be involved in the underlying mechanism of mesenchymal stem cells (MSCs) transplantation, and exosomes are an important component of this paracrine role. However, MSCs are usually exposed… read more here.
Keywords: hypo exos; bone fracture; mir 126; fracture ... See more keywords