miR‐130b directly targets ARHGAP1 to drive activation of a metastatic CDC42‐PAK1‐AP1 positive feedback loop in Ewing sarcoma
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Cancer"
DOI: 10.1002/ijc.30909
Abstract: Ewing Sarcoma (ES) is a highly aggressive bone tumor with peak incidence in the adolescent population. It has a high propensity to metastasize, which is associated with dismal survival rates of approximately 25%. To further… read more here.
Keywords: cdc42; ewing sarcoma; activation; mir 130b ... See more keywords
MiR‐130b increases fibrosis of HMC cells by regulating the TGF‐β1 pathway in diabetic nephropathy
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27688
Abstract: Basement membrane thickening, glomerular hypertrophy, and deposition of multiple extracellular matrix characterize the pathological basis of diabetic nephropathy (DN), a condition which ultimately leads to glomerular and renal interstitial fibrosis. Here, we identified a novel… read more here.
Keywords: fibrosis; diabetic nephropathy; hmc cells; 130b increases ... See more keywords
Levels of miR-130b-5p in peripheral blood are associated with severity of coronary artery disease.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular biology reports"
DOI: 10.1007/s11033-021-06780-5
Abstract: BACKGROUND Although patients with coronary artery disease (CAD) have a high mortality rate, the pathogenesis of CAD is still poorly understood. During the past decade, microRNAs (miRNAs) have emerged as new, potential diagnostic biomarkers in… read more here.
Keywords: hsa mir; cad; coronary artery; mir 130b ... See more keywords
Cytidine monophosphate kinase is inhibited by the TGF-β signalling pathway through the upregulation of miR-130b-3p in human epithelial ovarian cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2017.04.009
Abstract: Cytidine monophosphate kinase (CMPK), a member of the nucleoside monophosphate kinase family, plays an important role in the biosynthesis of nucleoside metabolism, DNA repair and tumour development. In this study, we demonstrated for the first… read more here.
Keywords: tgf signalling; signalling pathway; expression; cmpk ... See more keywords
MicroRNA-130b functions as an oncogene and is a predictive marker of poor prognosis in lung adenocarcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Laboratory Investigation"
DOI: 10.1038/s41374-020-00496-z
Abstract: Lung cancer is an aggressive disease and the leading cause of cancer-related deaths worldwide. In the past several decades, the incidence of adenocarcinoma has significantly increased, and accounts for ~40% of all lung cancer cases.… read more here.
Keywords: lung adenocarcinoma; microrna 130b; expression; cancer ... See more keywords
LncRNA HOTAIR influences cell proliferation via miR-130b/PTEN/AKT axis in IDD
Sign Up to like & getrecommendations! Published in 2022 at "Cell Cycle"
DOI: 10.1080/15384101.2021.2020042
Abstract: ABSTRACT Intervertebral disc degeneration (IDD) constitutes the pathological foundation of most musculoskeletal disorders of the spine. Previous studies have noted that cell proliferation is a common feature of IDD. Bioinformatics indicated that aberrantly expressed long… read more here.
Keywords: pten akt; proliferation; expression; mir 130b ... See more keywords
MiR-130b-3p promotes colorectal cancer progression by targeting CHD9
Sign Up to like & getrecommendations! Published in 2022 at "Cell Cycle"
DOI: 10.1080/15384101.2022.2029240
Abstract: ABSTRACT Colorectal cancer (CRC) is the third most common cancer worldwide. Previous research revealed that microRNA 130b-3p (miR-130b-3p) significantly upregulated in CRC patients can be detected in feces from patients with such a neoplasm. In… read more here.
Keywords: colorectal cancer; chd9; crc; mir 130b ... See more keywords
miR-130b regulates gap junctional intercellular communication through connexin 43 in granulosa cells from patients with polycystic ovary syndrome.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular human reproduction"
DOI: 10.1093/molehr/gaaa044
Abstract: MicroRNAs (miRNAs) are small, noncoding RNAs that negatively regulate gene expression post-transcriptionally. We explored whether connexin 43 (Cx43) was differently expressed in luteinized granulosa cells from women with polycystic ovary syndrome (PCOS) compared with luteinized… read more here.
Keywords: granulosa cells; junctional intercellular; intercellular communication; gap junctional ... See more keywords
miRNA‐130b‐5p promotes hepatic stellate cell activation and the development of liver fibrosis by suppressing SIRT4 expression
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.16766
Abstract: Liver fibrosis is a progressive disease accompanied by the deposition of extracellular matrix (ECM). Numerous reports have demonstrated that alterations in the expression of microRNAs (miRNAs) are related to liver disease. However, the effect of… read more here.
Keywords: fibrosis; liver fibrosis; expression; activation ... See more keywords
Impaired angiogenesis in diabetic critical limb ischemia is mediated by a miR-130b-INHBA signaling axis.
Sign Up to like & getrecommendations! Published in 2023 at "JCI insight"
DOI: 10.1172/jci.insight.163041
Abstract: Patients with peripheral artery disease (PAD) and diabetes constitute a high risk population for development of critical limb ischemia (CLI) and amputation, although the underlying mechanisms remain poorly understood. Comparison of dysregulated microRNAs from diabetic… read more here.
Keywords: limb; limb ischemia; inhba; mir 130b ... See more keywords
MiR-130b modulates the invasive, migratory, and metastatic behavior of leiomyosarcoma
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DOI: 10.1371/journal.pone.0278844
Abstract: Leiomyosarcoma (LMS) is an aggressive, often poorly differentiated cancer of the smooth muscle (SM) lineage for which the molecular drivers of transformation and progression are poorly understood. In microRNA (miRNA) profiling studies, miR-130b was previously… read more here.
Keywords: 130b modulates; modulates invasive; mir 130b; lms cells ... See more keywords