Mechanism of prolactin inhibition of miR‐135b via methylation in goat mammary epithelial cells
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.25925
Abstract: Prolactin is an important endocrine activator of lactogenesis. This study investigated the function and mechanism of miR‐135b in the enhancement of lactation by prolactin in goat mammary epithelial tissue. We utilized S‐Poly (T) sequencing to… read more here.
Keywords: mammary epithelial; prolactin; goat mammary; mir 135b ... See more keywords
MiR-135b promotes HCC tumorigenesis through a positive-feedback loop.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.07.008
Abstract: Hippo pathway plays critical roles in cell proliferation and apoptosis and its dysregulation leads to various types of cancers, including hepatocellular carcinoma (HCC). However, the mechanism maintaining Hippo pathway homeostasis still remains unclear. In this… read more here.
Keywords: positive feedback; mir 135b; hcc; hippo pathway ... See more keywords
MiR-135b protects cardiomyocytes from infarction through restraining the NLRP3/caspase-1/IL-1β pathway.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of cardiology"
DOI: 10.1016/j.ijcard.2019.09.055
Abstract: BACKGROUND Myocardial infarction (MI) is the most common cause of cardiovascular morbidity and mortality worldwide. Despite the identification of many pathogenic genes associated with MI, the underlying molecular mechanisms remain poorly understood. MicroRNAs (miRNAs, miRs),… read more here.
Keywords: caspase; nlrp3 caspase; caspase pathway; infarction ... See more keywords
Suppression of microRNA-135b-5p protects against myocardial ischemia/reperfusion injury by activating JAK2/STAT3 signaling pathway in mice during sevoflurane anesthesia
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DOI: 10.1042/bsr20170186
Abstract: The study aims to explore the effects of miR-135b-5p on myocardial ischemia/reperfusion (I/R) injuries by regulating Janus protein tyrosine kinase 2 (JAK2)/signal transducer and activator of transcription (STAT) signaling pathway by mediating inhalation anesthesia with… read more here.
Keywords: protein; jak2 stat3; expression; mir 135b ... See more keywords
MicroRNA-135b-5p regulates trophoblast cell function by targeting phosphoinositide-3-kinase regulatory subunit 2 in preeclampsia
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2073655
Abstract: ABSTRACT The level of miR‑135b-5p is lower in patients with preeclampsia (PE) superimposed on chronic hypertension than in healthy controls. However, the function of miR‑135b-5p in PE progression remains unknown. In the present study, we… read more here.
Keywords: trophoblast cell; function targeting; cell function; mir 135b ... See more keywords
Knockdown of Mir-135b Sensitizes Colorectal Cancer Cells to Oxaliplatin-Induced Apoptosis Through Increase of FOXO1
Sign Up to like & getrecommendations! Published in 2018 at "Cellular Physiology and Biochemistry"
DOI: 10.1159/000492284
Abstract: Background/Aims: Aberrant expression of microRNAs (miRNAs) is found to be responsible for tumorigenesis, cancer development and chemoresistance. Although oxaliplatin is an effective chemotherapeutic drug for treatment of colorectal cancer (CRC), CRC cells can develop some… read more here.
Keywords: oxaliplatin induced; apoptosis; anti mir; crc ... See more keywords
Overexpression of mir-135b and mir-210 in mesenchymal stromal cells for the enrichment of extracellular vesicles with angiogenic factors
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DOI: 10.1371/journal.pone.0272962
Abstract: Extracellular vesicles (EVs) are known as molecular carriers involved in cell communication and the regulation of (patho)physiological processes. miRNAs and growth factors are the main contents of EVs which make them a good candidate for… read more here.
Keywords: 135b mir; mir 210; mir 135b; extracellular vesicles ... See more keywords
MiR-135b-5p affected malignant behaviors of ovarian cancer cells by targeting KDM5B.
Sign Up to like & getrecommendations! Published in 2020 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_202004_20815
Abstract: OBJECTIVE The aim of this study was to investigate the potential effect of microRNA-135b-5p (miR-135b-5p) on the development of ovarian cancer (OC) and to explore the relevant mechanism. PATIENTS AND METHODS The expression of miR-135b-5p… read more here.
Keywords: cancer; mir 135b; targeting kdm5b; ovarian cancer ... See more keywords
miR-135b-5p promotes gastric cancer progression by targeting CMTM3.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of oncology"
DOI: 10.3892/ijo.2017.4222
Abstract: CKLF-like MARVEL transmembrane domain containing 3 (CMTM3) is considered to be a tumor suppressor gene in multiple types of malignancies. Previous studies have indicated that CMTM3 suppresses metastasis and epithelial-mesenchymal transition (EMT) in gastric cancer. However,… read more here.
Keywords: gastric cancer; cmtm3; mir 135b; progression ... See more keywords