Morphine‐mediated release of miR‐138 in astrocyte‐derived extracellular vesicles promotes microglial activation
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.12027
Abstract: Abstract Opioids, such as morphine, are the mainstay for the management of postsurgical pain. Over the last decade there has been a dramatic increase in deaths related to opioid overdose. While opioid abuse has been… read more here.
Keywords: extracellular vesicles; mir 138; release mir; activation ... See more keywords
MIR‐138‐5P inhibits the progression of prostate cancer by targeting FOXC1
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Genetics & Genomic Medicine"
DOI: 10.1002/mgg3.1193
Abstract: Studies have suggested that micro‐RNAs (miRNAs) can function as an oncogene or a tumor suppressor in cancers. However, the role of MIR‐138‐5P (613394) in prostate cancer (PCa) remains unclear. read more here.
Keywords: 138 inhibits; mir 138; inhibits progression; prostate cancer ... See more keywords
Activation of PGC‐1α via isoliquiritigenin‐induced downregulation of miR‐138‐5p alleviates nonalcoholic fatty liver disease
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7334
Abstract: Nonalcoholic fatty liver disease (NAFLD), a metabolic disease, has received wide attention worldwide. However, there is no approved effective drug for NAFLD treatment. In the study, H&E and Oil Red O staining were employed to… read more here.
Keywords: nonalcoholic fatty; fatty liver; isoliquiritigenin; disease ... See more keywords
CREPT regulated by miR-138 promotes breast cancer progression.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.09.033
Abstract: CREPT (also known as RPRD1B) function as an oncogene and is highly expressed in several kinds of cancers. However, the distribution and clinical significance of CREPT in breast cancer (BC) still not clarified. In this… read more here.
Keywords: crept regulated; expression; mir 138; breast cancer ... See more keywords
Generating 3D-cultured organoids for pre-clinical modeling and treatment of degenerative joint disease
Sign Up to like & getrecommendations! Published in 2021 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-021-00675-4
Abstract: Dear Editor, Human cell-based and personalized in vitro cartilage models are urgently needed for osteoarthritis treatment in pre-clinical regenerative medicine development. Cellular self-assemblies and condensations of the appropriate stem cells could initiate the formation of… read more here.
Keywords: mir 138; supplementary fig; smsc organoids; expression ... See more keywords
miR-138-5p promotes chicken granulosa cell apoptosis via targeting SIRT1.
Sign Up to like & getrecommendations! Published in 2022 at "Animal biotechnology"
DOI: 10.1080/10495398.2022.2095642
Abstract: Granulosa cell (GC) apoptosis is the main trigger of follicular atresia. MicroRNAs (miRNAs) are 18-22 nt RNAs whose function is primarily determined by their extended seed region and are considered to be involved in the biological… read more here.
Keywords: mir 138; 138 promotes; cell apoptosis; targeting sirt1 ... See more keywords
TIMP-1 suppressed by miR-138 participates in endoplasmic reticulum stress-induced osteoblast apoptosis in osteoporosis
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Research"
DOI: 10.1080/10715762.2017.1423070
Abstract: Abstract The aim of this study was to investigate the role of miR-138 in osteoporosis and its underlying mechanism. Hydrogen peroxide (H2O2) was used to induce osteoporotic injury of osteoblasts. The cell viability and apoptosis… read more here.
Keywords: apoptosis; mir 138; timp; stress induced ... See more keywords
Astragaloside-IV alleviates high glucose-induced ferroptosis in retinal pigment epithelial cells by disrupting the expression of miR-138-5p/Sirt1/Nrf2
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2049471
Abstract: ABSTRACT Astragaloside-IV (AS-IV) (C41H68O14) is a high-purity natural product extracted from Astragalus, which has demonstrated biological activities. However, the effect of AS-IV on retinal pigment epithelial (RPE) cells in diabetic retinopathy (DR) remains unclear. In… read more here.
Keywords: sirt1 nrf2; rpe cells; rpe; mir 138 ... See more keywords
Long noncoding RNA (lncRNA) metallothionein 1 J, pseudogene (MT1JP) is downregulated in triple-negative breast cancer and upregulates microRNA-138 (miR-138) to downregulate hypoxia-inducible factor-1α (HIF-1α)
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2077906
Abstract: ABSTRACT Triple-negative breast cancer (TNBC) is a highly invasive subtype of breast cancer. This study explored the molecular mechanism and influences of metallothionein 1 J, pseudogene (MT1JP), microRNA-138 (miR-138), and hypoxia-inducible factor-1α (HIF-1α) on TNBC cell… read more here.
Keywords: mir 138; hif; breast cancer; mt1jp ... See more keywords
Knockdown of Long Noncoding RNA Small Nucleolar RNA Host Gene 12 Inhibits Cell Growth and Induces Apoptosis by Upregulating miR-138 in Nonsmall Cell Lung Cancer.
Sign Up to like & getrecommendations! Published in 2017 at "DNA and cell biology"
DOI: 10.1089/dna.2017.3830
Abstract: Small nucleolar RNA host gene 12 (SNHG12) is a novel long noncoding RNA identified to be upregulated and functions as an oncogene in several cancers. However, the function of SNHG12 and its target genes in… read more here.
Keywords: small nucleolar; rna; mir 138; cell ... See more keywords
A Rare Rs139365823 Polymorphism in Pre-miR-138 Is Associated with Risk of Congenital Heart Disease in a Chinese Population.
Sign Up to like & getrecommendations! Published in 2018 at "DNA and cell biology"
DOI: 10.1089/dna.2017.4013
Abstract: miR-138 modulates cardiac morphogenesis in zebrafish. We explored whether a genetic polymorphism in miR-138 might contribute to the occurrence of sporadic congenital heart disease (CHD) and the potential mechanism. We performed a case-control study consisting… read more here.
Keywords: risk; rs139365823; pre mir; mir 138 ... See more keywords