Exosome mediated transfer of miRNA‐140 promotes enhanced chondrogenic differentiation of bone marrow stem cells for enhanced cartilage repair and regeneration
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.29657
Abstract: Exosomes (EXs) are nanocarrier vesicles with 20‐50 nm dimensions. They are involved in cell proliferation and differentiation and in protecting the integrity of materials. They can be isolated from plasma and immunoreactive components. Recent studies demonstrated… read more here.
Keywords: stem cells; marrow stem; differentiation; mir 140 ... See more keywords
Regulation of mitophagy through HIF‐1α/miR‐140‐5p/PARKIN axis in acute kidney injury
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23523
Abstract: Mitochondria homeostasis plays an important role in acute kidney injury (AKI). In this study, we aimed at identifying the mechanism of mitophagy regulation in AKI. Activation of mitophagy after ischemic kidney injury was visualized with… read more here.
Keywords: mitophagy; kidney injury; regulation; mir 140 ... See more keywords
[MiR-140-3p Downregulation in Association with PDL-1 Overexpression in Many Cancers: A Review from the Literature Using Predictive Bioinformatics Tools].
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-319-56246-9_18
Abstract: Programmed death-ligand 1 (PD-L1) has been speculated to play a critical role in suppression of the immune system and it can be upregulated in cancer cells, which may allow cancers to evade the host immune… read more here.
Keywords: 140 downregulation; association pdl; downregulation association; pdl overexpression ... See more keywords
Downregulation of miR-140-5p affects the pathogenesis of HSCR by targeting EGR2
Sign Up to like & getrecommendations! Published in 2020 at "Pediatric Surgery International"
DOI: 10.1007/s00383-020-04686-0
Abstract: Background/aims Hirschsprung's disease (HSCR) is the most common digestive disease caused by disorders of neural crest development. Despite the known involvement of miR-140-5p in many human diseases, its biological role in Hirschsprung’s disease (HSCR) remains… read more here.
Keywords: pathogenesis hscr; targeting egr2; hscr; mir 140 ... See more keywords
Intra-articular injection of hUC-MSCs expressing miR-140-5p induces cartilage self-repairing in the rat osteoarthritis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Bone and Mineral Metabolism"
DOI: 10.1007/s00774-019-01055-3
Abstract: Introduction Currently, osteoarthritis (OA) receives global increasing attention because it associates severe joint pain and serious disability. Stem cells intra-articular injection therapy showed a potential therapeutic superiority to reduce OA development and to improve treating… read more here.
Keywords: huc mscs; articular injection; mscs; intra articular ... See more keywords
miR-140-5p/miR-149 Affects Chondrocyte Proliferation, Apoptosis, and Autophagy by Targeting FUT1 in Osteoarthritis
Sign Up to like & getrecommendations! Published in 2018 at "Inflammation"
DOI: 10.1007/s10753-018-0750-6
Abstract: Osteoarthritis (OA), the most prevalent chronic and degenerative joint disease, is characterized by articular cartilage degradation and chondrocyte injury. Increased cell apoptosis and defective cell autophagy in chondrocytes are a feature of degenerative cartilage. MicroRNAs… read more here.
Keywords: mir 149; mir; proliferation; 140 mir ... See more keywords
Long non-coding RNA MEG3 inhibits adipogenesis and promotes osteogenesis of human adipose-derived mesenchymal stem cells via miR-140-5p
Sign Up to like & getrecommendations! Published in 2017 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-017-3015-z
Abstract: AbstractlncRNAs are an emerging class of regulators involved in multiple biological processes. MEG3, an lncRNA, acts as a tumor suppressor, has been reported to be linked with osteogenic differentiation of MSCs. However, limited knowledge is… read more here.
Keywords: meg3; adipogenesis; differentiation; hascs ... See more keywords
miR-140-3p functions as a tumor suppressor in squamous cell lung cancer by regulating BRD9.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer letters"
DOI: 10.1016/j.canlet.2019.01.007
Abstract: Squamous cell lung cancer (SqCLC) is among the most malignant lung cancers worldwide, lacking biomarkers for diagnostic and targets for treatment. In this study, we observed that miR-140-3p was expressed at low levels both in… read more here.
Keywords: cell; squamous cell; cell lung; cancer ... See more keywords
Inhibition of miR-140-3p or miR-155-5p by antagomir treatment sensitize chordoma cells to chemotherapy drug treatment by increasing PTEN expression.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2019.03.034
Abstract: Previous researches suggested microRNA-140-3p (miR-140-3p) and miR-155-5p as cancer promotor in chordoma. We aimed to investigate the mechanisms of these two miRNAs in chordoma cells. Patient-derived chordoma cell lines were established in vitro. Expressions of… read more here.
Keywords: mir 155; chordoma cells; treatment; 140 mir ... See more keywords
Therapeutic effect and potential mechanisms of intra-articular injections of miR-140-5p on early-stage osteoarthritis in rats.
Sign Up to like & getrecommendations! Published in 2021 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2021.107786
Abstract: MicroRNAs (miRs) receive extensive attention in osteoarthritis (OA) pathogenesis in recent years, and our previous study confirmed that an intra-articular injection (IAJ) of miR-140-5p alleviates early-stage OA (EOA) progression in rats. This study aims to… read more here.
Keywords: therapeutic effect; effect; early stage; intra articular ... See more keywords
MicroRNA-140 silencing represses the incidence of Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2021 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2021.135674
Abstract: Alzheimer's disease (AD) is a neurodegenerative condition leading to severe disability from progressive impairments in cognitive functions including memory and learning. Non-coding microRNAs (miRNAs or miRs) have been linked to the pathogenesis of AD. The… read more here.
Keywords: alzheimer disease; mir; 140 silencing; model rats ... See more keywords