Asiaticoside inhibits renal fibrosis development by regulating the miR-142-5p/ACTN4 axis.
Sign Up to like & getrecommendations! Published in 2021 at "Biotechnology and applied biochemistry"
DOI: 10.1002/bab.2110
Abstract: Renal fibrosis results in the progressive renal dysfunction and leads to chronic kidney disease (CKD) and ultimately end-stage renal disease. Asiaticoside was reported to regulate synaptopodin, desmin, nephrin and podocin levels in adriamycin-induced nephropathy of… read more here.
Keywords: 142 actn4; regulating mir; mir 142; actn4 axis ... See more keywords
Pinoresinol diglucoside ameliorates H/R‐induced injury of cardiomyocytes by regulating miR‐142‐3p and HIF1AN
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23175
Abstract: This study is aimed to investigate the effect of pinoresinol diglucoside (PDG) in ameliorating myocardial ischemia–reperfusion injury (MIRI). Hypoxia/reperfusion (H/R)‐induced H9c2 cardiomyocytes were used to establish an in‐vitro ischemia–reperfusion injury model of cardiomyocytes. Cells were… read more here.
Keywords: 142 hif1an; injury; h9c2; mir 142 ... See more keywords
Hsa_circ_0000119 promoted ovarian cancer development via enhancing the methylation of CDH13 by sponging miR‐142‐5p
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23264
Abstract: Ovarian cancer is the leading cause of gynecological cancer‐related death in women, and is difficult to treat. The aim of our study is to explore the role and action mechanism of hsa_circ_0000119 in ovarian cancer,… read more here.
Keywords: circ 0000119; hsa circ; ovarian cancer; mir 142 ... See more keywords
Downregulation of lncRNA TUG1 contributes to the development of sepsis‐associated acute kidney injury via regulating miR‐142‐3p/sirtuin 1 axis and modulating NF‐κB pathway
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28409
Abstract: This study intended to investigate the potential molecular mechanism of long noncoding RNA (lncRNA) taurine upregulated gene 1 (TUG1) in the development of sepsis‐associated acute kidney injury (AKI). The expression of TUG1 in the serum… read more here.
Keywords: tug1; mir 142; sepsis associated; injury ... See more keywords
miR‐142‐3p is a tumor suppressor that inhibits estrogen receptor expression in ER‐positive breast cancer
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28263
Abstract: Estrogen receptors (ERs) are involved in the development of many types of malignant tumors, in particular, breast cancer. Among others, ERs affect cell growth, proliferation, and differentiation. The microRNA (miRNA) miR‐142‐3p has been shown to… read more here.
Keywords: breast; positive breast; mir 142; breast cancer ... See more keywords
A critical role for miR-142 in alveolar epithelial lineage formation in mouse lung development
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-019-03067-8
Abstract: The respiratory epithelium arises from alveolar epithelial progenitors which differentiate into alveolar epithelial type 1 (AT1) and type 2 (AT2) cells. AT2 cells are stem cells in the lung critical for the repair process after… read more here.
Keywords: 142 alveolar; epithelial lineage; mir 142; expression ... See more keywords
Oleanolic acid attenuated diabetic mesangial cell injury by activation of autophagy via miRNA-142-5p/PTEN signaling
Sign Up to like & getrecommendations! Published in 2019 at "Cytotechnology"
DOI: 10.1007/s10616-019-00335-0
Abstract: Oleanolic acid (OA), a potential drug for diabetic nephropathy (DN) treatment was found to downregulate the expression of microRNA (miR). The research aimed to investigate the effect of OA on autophagy mediated through miR-142-5p targeted… read more here.
Keywords: nrk 52e; mir 142; autophagy; 52e cells ... See more keywords
Dysregulation of miR-142 results in anxiety-like behaviors following single prolonged stress
Sign Up to like & getrecommendations! Published in 2019 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2019.03.018
Abstract: &NA; Posttraumatic stress disorder (PTSD) is a prevalent mental disorder that is classified as a trauma‐ and stressor‐related disorder. While numerous epigenetic factors are related to the risk for PTSD, the precise mechanisms underlying this… read more here.
Keywords: single prolonged; anxiety like; mir 142; stress ... See more keywords
miR-142-5p regulates tumor cell PD-L1 expression and enhances anti-tumor immunity.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.05.074
Abstract: Cancer immunotherapy has many great achievements in recent years. One of the most promising cancer immunotherapies is PD-1/PD-L1 pathway blockade. miRNAs (MicroRNAs) belongs to small noncoding RNA and can regulate gene expression by binding to… read more here.
Keywords: tumor immunity; mir 142; anti tumor; expression ... See more keywords
miR-142-3p inhibits aerobic glycolysis and cell proliferation in hepatocellular carcinoma via targeting LDHA.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.01.112
Abstract: Cancer cells are addictively dependent on glycolysis even in an oxygen-rich condition. However, the mechanism underlying micro (mi)RNA regulation of aerobic glycolysis in cancer cells has not been fully understood. Here, we demonstrated that the… read more here.
Keywords: hepatocellular carcinoma; glycolysis; aerobic glycolysis; mir 142 ... See more keywords
Inhibiting microRNA-142-5p improves learning and memory in Alzheimer’s disease rats via targeted regulation of the PTPN1-mediated Akt pathway
Sign Up to like & getrecommendations! Published in 2022 at "Brain research bulletin"
DOI: 10.1016/j.brainresbull.2022.02.016
Abstract: OBJECTIVE MicroRNAs (miRNAs) have been recognized as possible biomarkers for Alzheimer's disease (AD). MiR-142-5p has been reported to be abnormally expressed in brain tissues. However, the role of miR-142-5p in AD pathogenesis keeps unclear. This… read more here.
Keywords: mir 142; akt pathway; learning memory; ptpn1 ... See more keywords