miR‐143 targets MAPK7 in CHO cells and induces a hyperproductive phenotype to enhance production of difficult‐to‐express proteins
Sign Up to like & getrecommendations! Published in 2017 at "Biotechnology Progress"
DOI: 10.1002/btpr.2475
Abstract: In recent years, the number of complex but clinically effective biologicals such as multi‐specific antibody formats and fusion proteins has increased dramatically. However, compared to classical monoclonal antibodies (mAbs), these rather artificially designed therapeutic proteins… read more here.
Keywords: mir 143; production; production difficult; cho cells ... See more keywords
Rs4705342 polymorphism is involved in the tumorigenesis of HBV positive HCC by altering the binding affinity of HBV induced NF‐kB with the promoter region of microRNA‐143
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26581
Abstract: The objective of this study was to explore the role of rs4705342 located in the miR‐143 promoter in relation to the control of HBV positive HCC and the underlying molecular mechanism. A luciferase assay was… read more here.
Keywords: mir 143; hbv positive; hbv; promoter ... See more keywords
Peripheral blood circulating microRNA‐4636/−143 for the prognosis of cervical cancer
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.29305
Abstract: Cervical cancer is the third leading cause of female death in the world. Serum microRNAs (miRNAs) are currently considered to be valuable as noninvasive cancer biomarkers, but their role in the prognosis of cervical cancer… read more here.
Keywords: mir 143; patients cervical; cervical cancer; prognosis cervical ... See more keywords
Identification of miR-143 as a Major Contributor for Human Stenotic Aortic Valve Disease
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cardiovascular Translational Research"
DOI: 10.1007/s12265-019-09880-7
Abstract: Calcification of aortic valves leads to aortic stenosis mainly in elderly individuals, but the underlying molecular mechanisms are still not understood. Here, we studied microRNA (miR, miRNA) expression and function in healthy and stenotic human… read more here.
Keywords: mir 143; aortic valves; stenotic aortic; disease ... See more keywords
Overexpression of long noncoding RNA MCM3AP-AS1 promotes osteogenic differentiation of dental pulp stem cells via miR-143-3p/IGFBP5 axis.
Sign Up to like & getrecommendations! Published in 2021 at "Human cell"
DOI: 10.1007/s13577-021-00648-3
Abstract: MCM3AP-AS1 regulates the cartilage repair in osteoarthritis, but how it regulates osteogenic differentiation of dental pulp stem cells (DPSCs) remains to be determined. DPSCs were isolated and induced for osteogenic differentiation. MCM3AP-AS1 expression was increased… read more here.
Keywords: mir 143; osteogenic differentiation; mcm3ap as1;
MiR-143-3p suppresses the progression of nasal squamous cell carcinoma by targeting Bcl-2 and IGF1R.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.08.075
Abstract: Dysregulated microRNAs (miRNAs) play crucial roles in the occurrence and development of multiple tumours, but their roles in the progression of nasal squamous cell carcinoma (NSCC) remain unknown. The aim of our study was to… read more here.
Keywords: mir 143; bcl igf1r; progression nasal; cell ... See more keywords
Restoration of miR-143 reduces migration and proliferation of bladder cancer cells by regulating signaling pathways involved in EMT.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular and cellular probes"
DOI: 10.1016/j.mcp.2022.101794
Abstract: MicroRNAs (miRNAs), a class of regulatory endogenous short RNAs, are involved in various biological functions by targeting the mRNA of multiple protein-coding genes and influencing their related signaling pathways. In this investigation, we upregulated microRNA-143… read more here.
Keywords: mir 143; signaling pathways; bladder cancer; migration ... See more keywords
MiR-31 and miR-143 affect steroid hormone synthesis and inhibit cell apoptosis in bovine granulosa cells through FSHR.
Sign Up to like & getrecommendations! Published in 2019 at "Theriogenology"
DOI: 10.1016/j.theriogenology.2018.09.020
Abstract: The regulatory role of microRNAs (miRNAs) has been explored in ovarian cells, and the effects of miRNAs on gonadal development, apoptosis, ovulation, and steroid production have been reported. In this study, we analyzed the effects… read more here.
Keywords: mir 143; apoptosis; mir mir; bovine ... See more keywords
Circulating miR‐143‐3p inhibition protects against insulin resistance in Metabolic Syndrome via targeting of the insulin‐like growth factor 2 receptor
Sign Up to like & getrecommendations! Published in 2019 at "Translational Research"
DOI: 10.1016/j.trsl.2018.09.006
Abstract: &NA; Metabolic syndrome (MetS) is characterized by a cluster of metabolic disorders including obesity, dyslipidemia, hyperglycemia, and hypertension. Here, we report that 27 microRNAs were found to be expressed differently in serum and urine samples… read more here.
Keywords: mir 143; insulin; metabolic syndrome; insulin resistance ... See more keywords
miR-143-Mediated Responses to Betaine Supplement Repress Lipogenesis and Hepatic Gluconeogenesis by Targeting MAT1a and MAPK11.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c02940
Abstract: The liver as the central organ is responsible for lipogenesis, gluconeogenesis and one-carbon metabolism. Methyl donors (e.g., betaine) modulate metabolic homeostasis and gene regulation through one-carbon metabolism. MiR-143 regulates DNA methylation by targeting DNMT3A, thereby… read more here.
Keywords: metabolism; mir 143; gluconeogenesis; lipogenesis ... See more keywords
Association between functional polymorphisms in the promoter of the miR-143/145 cluster and risk of intracranial aneurysm
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DOI: 10.1038/srep43633
Abstract: MicroRNAs (miRs)-143/145 are involved in various biological processes related to aneurysm formation and are downregulated in patients with intracranial aneurysm (IA). We aimed to determine whether two functional polymorphisms (i.e. rs4705342 and rs4705343) in the… read more here.
Keywords: mir 143; intracranial aneurysm; risk; promoter mir ... See more keywords