Physical Activity Modulates the Overexpression of the Inflammatory miR‐146a‐5p in Obese Patients
Sign Up to like & getrecommendations! Published in 2018 at "IUBMB Life"
DOI: 10.1002/iub.1926
Abstract: Specific microRNAs (miRs), including the “angio‐miR‐126” and the “inflamma‐miR‐146a‐5p,” have been proposed as biomarkers and even therapeutic targets of obesity‐associated metabolic diseases. Physical activity, a key measure of prevention for obesity and its complications, is… read more here.
Keywords: obese patients; physical activity; mir 146a; mir 126 ... See more keywords
MiR‐146a‐5p accelerates sepsis through dendritic cell activation and glycolysis via targeting ATG7
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23151
Abstract: To unveil the role and regulatory mechanism of miR‐146a‐5p in sepsis. A sepsis cell model was established via lipopolysaccharide (LPS)‐induction in dendritic cells (DCs). The maturation of DCs was evaluated via flow cytometry. Gene expression… read more here.
Keywords: mir 146a; cell activation; sepsis;
Altered expression patterns of complement factor H and miR‐146a genes in acute‐chronic phases in experimental autoimmune encephalomyelitis mouse
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28583
Abstract: Considerable advances have been made in identification of the involvement of immune modulators in diseases. There is growing evidence on the role of complement pathway in pathogenesis and course of multiple sclerosis (MS). Moreover, it… read more here.
Keywords: chronic phases; mir 146a; complement factor; expression ... See more keywords
TNF‐α‐induced exosomal miR‐146a mediates mesenchymal stem cell‐dependent suppression of urethral stricture
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28891
Abstract: The effective treatment of urethral stricture remains a medical problem. The use of proinflammatory cytokines as stimuli to improve the reparative efficacy of mesenchymal stem cells (MSCs) towards damaged tissues represents an evolving field of… read more here.
Keywords: tnf; mir 146a; exosomes derived; urethral stricture ... See more keywords
Expression and polymorphism of micro‐RNA according to body mass index and breast cancer presentation in Tunisian patients
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.3vma0618-218r
Abstract: Micro‐RNAs (miRs) constitute a class of small noncoding RNAs implicated in the regulation of gene expression by binding to target mRNAs. A miR can target several mRNAs, being involved in different biologic processes and pathologies.… read more here.
Keywords: expression; mir 146a; mir; breast cancer ... See more keywords
MiR‐146a regulates PM1‐induced inflammation via NF‐κB signaling pathway in BEAS‐2B cells
Sign Up to like & getrecommendations! Published in 2018 at "Environmental Toxicology"
DOI: 10.1002/tox.22561
Abstract: Exposure to particulate matter (PM) leads to kinds of cardiopulmonary diseases, such as asthma, COPD, arrhythmias, lung cancer, etc., which are related to PM‐induced inflammation. We have found that PM2.5 (aerodynamics diameter read more here.
Keywords: beas cells; mir 146a; induced inflammation; inflammation ... See more keywords
Fascin protein stabilization by miR-146a implicated in the process of a chronic inflammation-related colon carcinogenesis model
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DOI: 10.1007/s00011-018-1175-2
Abstract: ObjectiveIn sporadic colon tumors, multistep process of well-known genetic alterations accelerates carcinogenesis; however, this does not appear to be the case in inflammation-related ones. We previously established a model of inflammation-related colon carcinogenesis using human… read more here.
Keywords: mir 146a; related colon; inflammation; colon ... See more keywords
MiR-146a-5p promotes IL-1β-induced chondrocyte apoptosis through the TRAF6-mediated NF-kB pathway
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DOI: 10.1007/s00011-020-01346-w
Abstract: Objective This study aimed to explore the role of the miR-146a-5p/TRAF6/NF-KB axis in chondrocyte apoptosis. Methods Transcriptome sequencing for microRNA expression in control and osteoarthritic cartilage was performed. Bioinformatic analysis was performed to identify the… read more here.
Keywords: traf6 mediated; chondrocyte apoptosis; traf6; mir 146a ... See more keywords
miR-146a-3p suppressed the differentiation of hAMSCs into Schwann cells via inhibiting the expression of ERBB2
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DOI: 10.1007/s00441-020-03320-8
Abstract: Human amniotic mesenchymal stem cells (hAMSCs) can be differentiated into Schwann-cell-like cells (SCLCs) in vitro. However, the underlying mechanism of cell differentiation remains unclear. In this study, we explored the phenotype and multipotency of hAMSCs,… read more here.
Keywords: schwann; mir 146a; expression; differentiation ... See more keywords
miR-146a Inhibits dengue-virus-induced autophagy by targeting TRAF6
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DOI: 10.1007/s00705-017-3516-9
Abstract: During dengue virus (DENV) infection, the virus manipulates different cellular pathways to assure productive replication, including autophagy. However, it remains unclear how this autophagic process is regulated. Here, we have demonstrated a novel role for… read more here.
Keywords: dengue virus; induced autophagy; traf6; mir 146a ... See more keywords
LncPVT1 promotes cartilage degradation in diabetic OA mice by downregulating miR-146a and activating TGF-β/SMAD4 signaling
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Bone and Mineral Metabolism"
DOI: 10.1007/s00774-020-01199-7
Abstract: To investigate the role of LncRNA PVT1 (plasmacytoma variant translocation 1) in hyperglycemia-triggered cartilage damage using the diabetic osteoarthritis (OA) mice model. Streptozotocin (STZ) was used to induce mouse diabetes. Knee OA model was induced… read more here.
Keywords: mir 146a; pvt1; tgf smad4; mice ... See more keywords