Gypenoside A attenuates dysfunction of pancreatic β cells by activating PDX1 signal transduction via the inhibition of miR‐150‐3p both in vivo and in vitro
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23004
Abstract: Saponin gypenoside A (GP) has shown its potential to handle diabetes mellitus. MicroRNA‐150‐3p (miR‐150‐3p) is closely related to the dysfunction of pancreatic β cells by targeting PDX1. Given the function of GP is related to… read more here.
Keywords: dysfunction pancreatic; pancreatic cells; expression; dysfunction ... See more keywords
MiR‐150 alleviates neuropathic pain via inhibiting toll‐like receptor 5
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DOI: 10.1002/jcb.26269
Abstract: MicroRNAs (miRNAs) are reported as vital participators in the pathophysiological course of neuropathic pain. However, the underlying mechanisms of the functional roles of miRNAs in neuropathic pain are largely unknown. This study was designed to… read more here.
Keywords: toll like; like receptor; mir 150; neuropathic pain ... See more keywords
miR‐150‐504‐519d inhibits the growth of human colorectal cancer cell line SW48 and downregulates c‐FLIP receptor
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28073
Abstract: microRNAs (miRNAs) are noncoding RNAs that regulates the expression of target messenger RNAs (mRNAs). c‐FLIP is an inhibitor of cell apoptosis through inhibition of caspase 8. miR‐150, miR‐504, and miR‐519d were related to cancer cell… read more here.
Keywords: 504 519d; colorectal cancer; mir 150; 150 504 ... See more keywords
miR‐150‐mediated increase in glucose uptake in HIV‐infected cells
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Medical Virology"
DOI: 10.1002/jmv.26755
Abstract: Replication of HIV‐1 inside host cells is dependent on both viral and host factors. MicroRNAs are small noncoding RNAs that regulate protein synthesis. MicroRNAs may control viral replication either by directly targeting the viral genome… read more here.
Keywords: hiv; increase; mir 150; expression ... See more keywords
miR-150 inhibitor ameliorates adriamycin-induced focal segmental glomerulosclerosis.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.11.096
Abstract: Focal segmental glomerulosclerosis (FSGS) is the most common cause of adult nephrotic syndrome in USA. Its mechanisms remain unclear and the effective treatment lacks. We previously reported that upregulation of microRNA (miR)-150 in human podocytes… read more here.
Keywords: focal segmental; anti mir; mir; adriamycin induced ... See more keywords
BMSCs-derived exosomal microRNA-150-5p attenuates myocardial infarction in mice.
Sign Up to like & getrecommendations! Published in 2021 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2021.107389
Abstract: OBJECTIVE MicroRNAs (miRNAs) have engaged in the progression of myocardial infarction (MI). Nevertheless, the mechanism of miR-150-5p in MI is still in its infancy. Therefore, the present study was set out to investigate the effect… read more here.
Keywords: derived exosomal; mir 150; expression; mice ... See more keywords
LongShengZhi alleviated cardiac remodeling via upregulation microRNA-150-5p with matrix metalloproteinase 14 as the target.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2022.115156
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE LongShengZhi capsule (LSZ), a traditional Chinese medicine, is used for treatment of patients with vascular diseases. LSZ reduced doxorubicin-induced heart failure by reducing production of reactive oxygen species and inhibiting inflammation anf apoptosis.… read more here.
Keywords: mir 150; upregulation; cardiac remodeling; ang induced ... See more keywords
MicroRNA-150 targets PU.1 and regulates macrophage differentiation and function in experimental autoimmune encephalomyelitis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neuroimmunology"
DOI: 10.1016/j.jneuroim.2018.06.010
Abstract: PU.1 is a transcription factor which is expressed in myeloid cells. Herein, we investigated the expression of PU.1 and its potentially targeting miRNAs in the central nervous system (CNS) of mice with experimental autoimmune encephalitis… read more here.
Keywords: autoimmune; microrna 150; targets regulates; mir 150 ... See more keywords
Cost‐Effectiveness Analysis of Icotinib vs Whole‐Brain Irradiation in NSCLC Patients with Brain Metastases: P044
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DOI: 10.1016/j.jtho.2018.10.067
Abstract: vector and co-transfected these reporters with miR-150-3p mimics in NSCLC cells. We tested the expression levels of SRCIN1 and miR150-3p in 163 NSCLC tumor tissues and the results demonstrated that the negative correlation between miR-150-3p… read more here.
Keywords: lincrna00494; srcin1 expression; mir 150; expression ... See more keywords
MicroRNA-150 deficiency accelerates intimal hyperplasia by acting as a novel regulator of macrophage polarization.
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DOI: 10.1016/j.lfs.2019.116985
Abstract: BACKGROUND The infiltration and activation of macrophages play key roles in arterial restenosis, providing a promising strategy for the treatment of restenosis caused by intimal hyperplasia. Although miR-150 has been implicated in cardiovascular diseases, the… read more here.
Keywords: 150 deficiency; intimal hyperplasia; mir 150; macrophage ... See more keywords
MicroRNA-150 inhibits myeloid-derived suppressor cells proliferation and function through negative regulation of ARG-1 in sepsis.
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DOI: 10.1016/j.lfs.2021.119626
Abstract: AIMS Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. The majority of sepsis-related deaths occur during late sepsis, which presents as a state of immunosuppression. Myeloid-derived suppressor cells… read more here.
Keywords: sepsis; derived suppressor; proliferation; mir 150 ... See more keywords