Genetic Deficiency of MicroRNA-15a/16-1 Confers Resistance to Neuropathological Damage and Cognitive Dysfunction in Experimental Vascular Cognitive Impairment and Dementia.
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DOI: 10.1002/advs.202104986
Abstract: Chronic cerebral hypoperfusion-derived brain damage contributes to the progression of vascular cognitive impairment and dementia (VCID). Cumulative evidence has shown that microRNAs (miRs) are emerging as novel therapeutic targets for CNS disorders. In this study,… read more here.
Keywords: impairment dementia; vcid; damage; vascular cognitive ... See more keywords
Paeonol inhibits chronic constriction injury‐induced astrocytic activation and neuroinflammation in rats via the HDAC/miR‐15a pathway
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DOI: 10.1002/ddr.21993
Abstract: Neuropathic pain affects millions of people in the worldwide, but the major therapeutics perform limited effectiveness. Paeonol (PAE) is widely distributed in Paeonis albiflora, and has manifested anti‐inflammatory and antioxidative effects in multiple diseases. The… read more here.
Keywords: hdac mir; paeonol; astrocytic activation; constriction injury ... See more keywords
Downregulation of microRNA‐15a‐3p is correlated with clinical outcome and negatively regulates cancer proliferation and migration in human osteosarcoma
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DOI: 10.1002/jcb.26294
Abstract: In this study, we investigated the expression, correlation to clinical outcomes and biological functions of microRNA‐15a‐3p (miR‐15a‐3p) in human osteosarcoma. MiR‐15a‐3p expressions in osteosarcoma cell lines and clinical tissues of osteosarcoma patients were measured by… read more here.
Keywords: proliferation migration; mir 15a; osteosarcoma; cancer ... See more keywords
The miR‐15a/16 gene cluster in human cancer: A systematic review
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27342
Abstract: MicroRNAs (miRNAs) are an important class of endogenous small noncoding single‐stranded RNAs that suppress the expression of their target genes through messenger RNA (mRNA) degradation to inhibit transcription and translation. MiRNAs play a crucial regulatory… read more here.
Keywords: 15a gene; cluster human; mir 15a; gene cluster ... See more keywords
miR‐15a‐5p suppresses inflammation and fibrosis of peritoneal mesothelial cells induced by peritoneal dialysis via targeting VEGFA
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27660
Abstract: Long‐term peritoneal dialysis (PD) often ends up with ultrafiltration failure (UFF) which is partially caused by persistent inflammation and fibrosis of peritoneal tissues. However, the mechanism is still unclear. In the current study, the peritoneum… read more here.
Keywords: inflammation fibrosis; fibrosis peritoneal; mir 15a; mesothelial cells ... See more keywords
MicroRNA-15a tissue expression is a prognostic marker for survival in patients with clear cell renal cell carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Clinical and Experimental Medicine"
DOI: 10.1007/s10238-019-00574-7
Abstract: None of the currently investigated molecular markers demonstrated sufficient accuracy in prognostication of the renal cell carcinoma (RCC) oncologic outcomes; thus, none of them has been recommended for the application in the routine clinical practice.… read more here.
Keywords: renal cell; expression; tissue expression; mir 15a ... See more keywords
ADRB2 suppresses IL-13-induced allergic rhinitis inflammatory cytokine regulated by miR-15a-5p
Sign Up to like & getrecommendations! Published in 2019 at "Human Cell"
DOI: 10.1007/s13577-019-00259-z
Abstract: Abstract Allergic rhinitis (AR) is a common hypersensitive disease that troubles patients a lot. Nasal epithelial cells (NECs), as the outmost protection of inhalation, play an important role in AR allergic response. Adrenoceptor beta 2… read more here.
Keywords: allergic rhinitis; regulated mir; nasal epithelial; mir 15a ... See more keywords
Induction of miR-15a expression by tripterygium glycosides caused premature ovarian failure by suppressing the Hippo-YAP/TAZ signaling effector Lats1.
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DOI: 10.1016/j.gene.2018.08.018
Abstract: Tripterygium glycosides (TGs) are chemotherapeutic drugs and immunosuppressant agents for the treatment of cancer and autoimmune diseases. We have previously reported that TGs induces premature ovarian failure (POF) by inducing cytotoxicity in ovarian granulosa cells… read more here.
Keywords: yap taz; expression; hippo yap; mir 15a ... See more keywords
Altered Expression of MicroRNA-15a and Kruppel-Like Factor 4 in Cerebrospinal Fluid and Plasma After Aneurysmal Subarachnoid Hemorrhage.
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DOI: 10.1016/j.wneu.2017.09.008
Abstract: BACKGROUND Cerebral vasospasm (CVS) is a major determinant of prognosis in patients with subarachnoid hemorrhage (SAH). Alteration in the vascular phenotype contributes to development of CVS. However, little is known about the role of microRNAs… read more here.
Keywords: plasma; mir 15a; microrna 15a; subarachnoid hemorrhage ... See more keywords
MicroRNA-15a-5p acts as a tumor suppressor in histiocytosis by mediating CXCL10-ERK-LIN28a-let-7 axis
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DOI: 10.1038/s41375-021-01472-2
Abstract: Erdheim–Chester disease (ECD) is characterized by excessive production and accumulation of histiocytes within multiple tissues and organs. ECD patients harbor recurrent mutations of genes associated with the RAS/RAF/MEK/ERK signaling pathway, particularly, the BRAFV600E mutation. Following… read more here.
Keywords: mir 15a; ecd patients; tumor suppressor; cxcl10 ... See more keywords
LncRNA PFAR contributes to fibrogenesis in lung fibroblasts through competitively binding to miR-15a
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DOI: 10.1042/bsr20190280
Abstract: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, debilitating disease with unknown etiopathogenesis. Previous reports have reported that long non-coding RNAs (lncRNAs) were involved in various pathophysiological processes. However, the role of lncRNAs in IPF… read more here.
Keywords: lncrna pfar; lung fibroblasts; fibrosis; mir 15a ... See more keywords