Autophagy inhibits cancer stemness in triple‐negative breast cancer via miR‐181a‐mediated regulation of ATG5 and/or ATG2B
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13180
Abstract: Autophagy has a dual role in the maintenance of cancer stem cells (CSCs), but the precise relationship between autophagy and cancer stemness requires further investigation. In this study, it was found that luminal and triple‐negative… read more here.
Keywords: mir 181a; triple negative; cancer stemness; cancer ... See more keywords
Interference of the long noncoding RNA CDKN2B‐AS1 upregulates miR‐181a‐5p/TGFβI axis to restrain the metastasis and promote apoptosis and senescence of cervical cancer cells
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Medicine"
DOI: 10.1002/cam4.2040
Abstract: Long noncoding RNA (lncRNA) CDKN2B‐AS1 has been shown to play a crucial role in the development as well as in the prognosis of various human cancers, including cervical cancer. However, the underlying mechanisms need to… read more here.
Keywords: cervical cancer; cdkn2b; mir 181a; cdkn2b as1 ... See more keywords
MicroRNA‐181a regulates the activation of the NLRP3 inflammatory pathway by targeting MEK1 in THP‐1 macrophages stimulated by ox‐LDL
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28637
Abstract: Atherosclerosis (AS) is a chronic inflammatory disease that is characterized by the deposition of lipids in the vascular wall and the formation of foam cells. Macrophages play a critical role in the development of this… read more here.
Keywords: related proteins; pathway; expression; thp macrophages ... See more keywords
Highly‐metastatic colorectal cancer cell released miR‐181a‐5p‐rich extracellular vesicles promote liver metastasis by activating hepatic stellate cells and remodelling the tumour microenvironment
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.12186
Abstract: Abstract Liver metastasis of colorectal cancer (CRLM) is the most common cause of CRC‐related mortality, and is typically caused by interactions between CRC cells and the tumour microenvironment (TME) in the liver. However, the molecular… read more here.
Keywords: mir 181a; crc; colorectal cancer; liver metastasis ... See more keywords
N6‐methyladenosine modification in trophoblasts promotes circSETD2 expression, inhibits miR‐181a‐5p, and elevates MCL1 transcription to reduce apoptosis of trophoblasts
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23683
Abstract: Preeclampsia (PE) is an obstetric disorder. N6‐methyladenosine (m6A) modification is related to PE trophoblast biological behaviors. This study explored the mechanism of m6A‐modified circSETD2 in trophoblast biological behaviors. Chorionic trophoblast apoptosis and circSETD2 expression in… read more here.
Keywords: modification; circsetd2; apoptosis; circsetd2 expression ... See more keywords
The lncRNA MIAT/miR-181a-5p axis regulates osteopontin (OPN)-mediated proliferation and apoptosis of human chondrocytes in osteoarthritis.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of molecular histology"
DOI: 10.1007/s10735-022-10067-9
Abstract: Osteoarthritis (OA) is a slow-progressing degenerative joint disease mainly characterized by progressive cartilage loss and subchondral bone remodeling. Osteopontin (OPN) is a matrix extracellular glyco-phosphoprotein capable of regulating the expression levels of multiple factors linked… read more here.
Keywords: miat; apoptosis; axis; proliferation apoptosis ... See more keywords
3064 – PREDICTIVE VALUE OF MIRNA 181A IN PEDIATRIC ACUTE LYMPHOBLASTIC LEUKEMIA
Sign Up to like & getrecommendations! Published in 2020 at "Experimental Hematology"
DOI: 10.1016/j.exphem.2020.09.081
Abstract: Context Acute lymphoblastic leukemia (ALL) represents the most common type of pediatric malignant neoplasm. The miRNAs play an important role in the regulation of normal hematopoiesis and their disruption contributes to leukemogenesis and considered novel… read more here.
Keywords: leukemia; acute lymphoblastic; lymphoblastic leukemia; mirna 181a ... See more keywords
Epigenetic down-regulation of BKCa channel by miR-181a contributes to the fetal and neonatal nicotine-mediated exaggerated coronary vascular tone in adult life.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of cardiology"
DOI: 10.1016/j.ijcard.2019.01.099
Abstract: BACKGROUND Fetal origin of adult cardiovascular disease is one of the most pressing public concerns and economic problem in modern life. Maternal cigarette smoking/nicotine abuse increases the risk of cardiovascular disease in offspring. However, the… read more here.
Keywords: nicotine; coronary vascular; vascular tone; bkca ... See more keywords
Co‐delivery of miR‐181a and melphalan by lipid nanoparticles for treatment of seeded retinoblastoma
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Controlled Release"
DOI: 10.1016/j.jconrel.2019.02.014
Abstract: Abstract Melphalan is an efficient chemotherapeutic agent that is currently used to treat retinoblastoma (Rb); however, the inherent risk of immunogenicity and the hazardous integration of this drug in healthy cells is inevitable. MicroRNAs are… read more here.
Keywords: melphalan; retinoblastoma; lipid nanoparticles; gene ... See more keywords
miR-181a promotes porcine granulosa cell apoptosis by targeting TGFBR1 via the activin signaling pathway
Sign Up to like & getrecommendations! Published in 2020 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2019.110603
Abstract: Activin/Smad3 signaling plays a pivotal role in follicle development and atresia. However, the precise mechanisms underlying this process are not yet fully understood. Herein, we identified miR-181a as a central component of activin/Smad3-mediated follicle atresia.… read more here.
Keywords: activin; apoptosis; apoptosis targeting; porcine granulosa ... See more keywords
Mesenchymal stem cell-conditioned medium alleviates high fat-induced hyperglucagonemia via miR-181a-5p and its target PTEN/AKT signaling
Sign Up to like & getrecommendations! Published in 2021 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2021.111445
Abstract: BACKGROUND α-cell dysregulation gives rise to fasting and postprandial hyperglycemia in type 2 diabetes mellitus(T2DM). Administration of Mesenchymal stem cells (MSCs) or their conditioned medium can improve islet function and enhance insulin secretion. However, studies… read more here.
Keywords: conditioned medium; akt signaling; pten akt; cell ... See more keywords