Saponin from Platycodi radix inactivates PI3K/AKT signaling pathway to hinder colorectal cancer cell proliferation, invasion, and migration through miR‐181c/d‐5p/RBM47
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23474
Abstract: Colorectal cancer (CRC) is the third frequent cancer and second leading reason of cancer‐related mortality all over the globe. Saponins from Platycodi radix (SPR) and microRNAs (miRNAs) have been reported to regulate CRC cell progression.… read more here.
Keywords: cell proliferation; rbm47; crc; mir 181c ... See more keywords
Expression of MicroRNAs miR-145, miR-181c, miR-199a and miR-1183 in the Blood and Hippocampus of Patients with Mesial Temporal Lobe Epilepsy
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Neuroscience"
DOI: 10.1007/s12031-019-01386-w
Abstract: The aim of this study was to analyze the expression profiles of the microRNAs (miRNAs) miR-145, miR-181c, miR-199a and miR-1183 in the hippocampus and blood of patients with mesial temporal lobe epilepsy with hippocampal sclerosis… read more here.
Keywords: hippocampus; mir 145; mir; 145 mir ... See more keywords
MiR-181c restrains nitration stress of endothelial cells in diabetic db/db mice through inhibiting the expression of FoxO1.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.02.083
Abstract: Endothelial dysfunction played an important role in the progression of diabetes mellitus (DM). miR-181c has been implicated in many diseases, including DM. However, the molecular mechanisms of miR-181c regulate this process remained poorly understood. Healthy… read more here.
Keywords: foxo1; mir 181c; expression; endothelial cells ... See more keywords
miR-181c level predicts response to exercise training in patients with heart failure and preserved ejection fraction: an analysis of the OptimEx-Clin trial.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of preventive cardiology"
DOI: 10.1093/eurjpc/zwab151
Abstract: AIMS In patients with heart failure with preserved ejection fraction (HFpEF), exercise training improves the quality of life and aerobic capacity (peakV·O2). Up to 55% of HF patients, however, show no increase in peakV·O2 despite… read more here.
Keywords: heart; response; training; mir 181c ... See more keywords
Downregulation of Long Noncoding RNA LUCAT1 Suppresses the Migration and Invasion of Bladder Cancer by Targeting miR-181c-5p
Sign Up to like & getrecommendations! Published in 2020 at "BioMed Research International"
DOI: 10.1155/2020/4817608
Abstract: Purpose The long noncoding RNA LUCAT1 (lung cancer-associated transcript 1) has been reported to be highly expressed in bladder cancer samples, but its role and molecular mechanisms need to be elucidated. Methods Bioinformatics methods show… read more here.
Keywords: bladder cancer; bladder; migration; mir 181c ... See more keywords
Abstract 4448: Elevated levels of circulating miR-34a-5p and miR-181c-3p during cancer initiation by aflatoxin B1
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-4448
Abstract: MicroRNAs are small non-coding RNAs that affect gene expression. They are essential in normal physiological processes and have been implicated in carcinogenesis. Hepatocellular carcinoma (HCC) is the second leading cause of cancer death globally, with… read more here.
Keywords: mir 34a; mir; mir 181c; cancer initiation ... See more keywords
Lower serum expression of miR-181c-5p is associated with increased plasma levels of amyloid-beta 1–40 and cerebral vulnerability in normal aging
Sign Up to like & getrecommendations! Published in 2019 at "Translational Neurodegeneration"
DOI: 10.1186/s40035-019-0174-8
Abstract: BackgroundPrevious studies have shown that expression levels of miR-181c are downregulated by amyloid-β (Aβ) deposition and chronic cerebral hypoperfusion, both factors largely associated with the development of AD. Moreover, reduced 2-[18F]fluoro-2-deoxy-D-glucose (FDG)-PET brain metabolism and… read more here.
Keywords: serum expression; 181c associated; mir 181c; expression ... See more keywords
Role of miR-181c in Diet-induced obesity through regulation of lipid synthesis in liver
Sign Up to like & getrecommendations! Published in 2021 at "PLoS ONE"
DOI: 10.1371/journal.pone.0256973
Abstract: We recently identified a nuclear-encoded miRNA (miR-181c) in cardiomyocytes that can translocate into mitochondria to regulate mitochondrial gene mt-COX1 and influence obesity-induced cardiac dysfunction through the mitochondrial pathway. Because liver plays a pivotal role during… read more here.
Keywords: 181c mice; obesity; lipid synthesis; liver ... See more keywords
High expression of miR-181c as a predictive marker of recurrence in stage II colorectal cancer
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.14344
Abstract: INTRODUCTION A standard treatment for stage II colorectal cancer (CRC) is surgical resection without adjuvant chemotherapy. However, the recurrence rate of these patients is approximately 20%. To date, there are no robust biomarkers suitable for… read more here.
Keywords: recurrence stage; recurrence; mir 181c; expression ... See more keywords
MiR-181c protects cardiomyocyte injury by preventing cell apoptosis through PI3K/Akt signaling pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Cardiovascular diagnosis and therapy"
DOI: 10.21037/cdt-20-490
Abstract: Background Cardiomyocyte apoptosis plays an important role in the development of heart failure, which leads to high mortality in patients with cardiovascular diseases. In this study, we are focused to identify the role of miRNA-181c… read more here.
Keywords: heart; apoptosis; tissue; cell apoptosis ... See more keywords
Down-Regulation of MiR-181c-5p Promotes Epithelial-to-Mesenchymal Transition in Laryngeal Squamous Cell Carcinoma via Targeting SERPINE1
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2020.544476
Abstract: Laryngeal squamous cell carcinoma (LSCC) arises from the squamous epithelium of the larynx and is associated with a high incidence of cervical lymph node metastasis. MicroRNAs (miRNAs) play a crucial role in the epigenetic regulation… read more here.
Keywords: laryngeal squamous; squamous cell; metastasis; mir 181c ... See more keywords