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   Articles with "mir 186" as a keyword



microRNA‐186 alleviates oxygen‐glucose deprivation/reoxygenation‐induced injury by directly targeting hypoxia‐inducible factor‐1α

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recommendations! Published in 2021 at "Journal of Biochemical and Molecular Toxicology"

DOI: 10.1002/jbt.22752

Abstract: Previous studies have suggested that microRNA‐186 (miR‐186) can be induced under hypoxic conditions, and is associated with apoptosis. This study was undertaken to explore the exact role of this microRNA (miRNA) in the apoptotic death… read more here.

Keywords: microrna 186; glucose deprivation; oxygen glucose; mir 186 ... See more keywords

CircRNA circPDSS1 promotes the gastric cancer progression by sponging miR‐186‐5p and modulating NEK2

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recommendations! Published in 2019 at "Journal of Cellular Physiology"

DOI: 10.1002/jcp.27714

Abstract: The aim of this study is to investigate the regulatory mechanism of circPDSS1/miR‐186‐5p/NEK2 axis on the viability and proliferation in gastric cancer (GC) cell line. Differentially expressed circRNAs, miRNAs, and mRNAs in GC tissues and… read more here.

Keywords: 186 nek2; gastric cancer; sponging mir; circpdss1 ... See more keywords

Overexpression of microRNA‐186 inhibits angiogenesis in retinoblastoma via the Hedgehog signaling pathway by targeting ATAD2

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recommendations! Published in 2019 at "Journal of Cellular Physiology"

DOI: 10.1002/jcp.28545

Abstract: Retinoblastoma (RB) represents an aggressive malignancy in the eye during the period of infancy and childhood. We delineated the ability of microRNA‐186 (miR‐186) to influence viability, invasion, migration, angiogenesis, and apoptosis of RB via the… read more here.

Keywords: microrna 186; hedgehog signaling; angiogenesis; signaling pathway ... See more keywords

M1 Macrophage-Derived Exosome LncRNA PVT1 Promotes Inflammation and Pyroptosis of Vascular Smooth Muscle Cells in Abdominal Aortic Aneurysm by Inhibiting miR-186-5p and Regulating HMGB1

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recommendations! Published in 2024 at "Cardiovascular Toxicology"

DOI: 10.1007/s12012-024-09838-5

Abstract: Abdominal aortic aneurysm (AAA) is a chronic vascular degenerative disease. Vascular smooth muscle cells (VSMCs) are essential for maintaining the integrity of healthy blood vessels. Macrophages play an important role in the inflammatory process of… read more here.

Keywords: pvt1; pyroptosis; mir 186; hmgb1 ... See more keywords

Suppression of Disheveled–Axin Domain Containing 1 (DIXDC1) by MicroRNA-186 Inhibits the Proliferation and Invasion of Retinoblastoma Cells

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recommendations! Published in 2017 at "Journal of Molecular Neuroscience"

DOI: 10.1007/s12031-017-1017-7

Abstract: Recent evidence shows that Disheveled–Axin domain containing 1 (DIXDC1) is dysregulated in various cancers. However, the role of DIXDC1 in retinoblastoma (RB) remains unclear. In this study, we aimed to investigate the biological function of… read more here.

Keywords: dixdc1; mir 186; expression; proliferation invasion ... See more keywords

MicroRNA profiling identifies Forkhead transcription factor M1 (FOXM1) regulated miR-186 and miR-200b alterations in triple negative breast cancer.

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recommendations! Published in 2021 at "Cellular signalling"

DOI: 10.1016/j.cellsig.2021.109979

Abstract: Breast cancer (BC) is the most commonly diagnosed malignancy. MicroRNAs (miRNAs) play important roles in the tumorigenesis, metastasis and progression of BC. Forkhead Box M1 (FOXM1) oncogenic transcription factor is involved in events considered as… read more here.

Keywords: foxm1; mir 200b; breast cancer; cancer ... See more keywords

MiR-186-5p inhibition restores synaptic transmission and neuronal network activity in a model of chronic stress

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recommendations! Published in 2024 at "Molecular Psychiatry"

DOI: 10.1038/s41380-024-02715-1

Abstract: Chronic stress exerts profound negative effects on cognitive and emotional behaviours and is a major risk factor for the development of neuropsychiatric disorders. However, the molecular links between chronic stress and its deleterious effects on… read more here.

Keywords: model chronic; synaptic transmission; chronic stress; mir 186 ... See more keywords

SNHG1-miR-186-5p-YY1 feedback loop alleviates hepatic ischemia/reperfusion injury

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recommendations! Published in 2022 at "Cell Cycle"

DOI: 10.1080/15384101.2022.2046984

Abstract: ABSTRACT As a common cause of liver injury, hepatic ischemia/reperfusion injury (HIRI) happens in various clinical conditions including trauma, hepatectomy and liver transplantation. Since transcription factor Yin Yang 1 (YY1) was reported to be downregulated… read more here.

Keywords: reperfusion injury; injury; ischemia reperfusion; mir 186 ... See more keywords

Circ_0035381 contributes to the progression of acute myeloid leukemia via regulating miR-186-5p/CDCA3 pathway

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recommendations! Published in 2025 at "Expert Review of Hematology"

DOI: 10.1080/17474086.2025.2484377

Abstract: ABSTRACT Background Circular RNAs (circRNAs) are involved in acute myeloid leukemia (AML) and may be useful for AML therapy. Herein, the project aimed to explore the functions and mechanisms of circ_0035381 in AML. Research design… read more here.

Keywords: mir 186; acute myeloid; aml; cell ... See more keywords
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miR-186-3p attenuates the tumorigenesis of cervical cancer via targeting insulin-like growth factor 1 to suppress PI3K-Akt signaling pathway.

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recommendations! Published in 2021 at "Bioengineered"

DOI: 10.1080/21655979.2021.1977053

Abstract: miR-186-3p acts as a tumor suppressor in various cancers. This study aimed to explore the expression levels of miR-186-3p and its role in cervical cancer. We analyzed the effects of miR-186-3p and insulin-like growth factor… read more here.

Keywords: akt signaling; cervical cancer; pi3k akt; signaling pathway ... See more keywords

Insights on P2X7 in patients with abdominal aortic aneurysm and carotid atherosclerosis

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recommendations! Published in 2024 at "Cardiovascular Research"

DOI: 10.1093/cvr/cvae088.162

Abstract: Type of funding sources: Public grant(s) – National budget only. Main funding source(s): Ministero della Salute, Italia, Rete Cardiologica Nazionale Carotid atherosclerosis and abdominal aortic aneurysm (AAA) are co-morbidities [1]. P2X-purinoceptor-7 (P2X7) is expressed both… read more here.

Keywords: p2x7; carotid; mir 186; cpl ... See more keywords