Epithelial to mesenchymal transition influences fibroblast phenotype in colorectal cancer by altering miR‐200 levels in extracellular vesicles
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.12226
Abstract: Abstract Colorectal cancer (CRC) with a mesenchymal gene expression signature has the greatest propensity for distant metastasis and is characterised by the accumulation of cancer‐associated fibroblasts in the stroma. We investigated whether the epithelial to… read more here.
Keywords: extracellular vesicles; mir 200; crc; colorectal cancer ... See more keywords
The regulatory network of miR-141 in the inhibition of angiogenesis
Sign Up to like & getrecommendations! Published in 2018 at "Angiogenesis"
DOI: 10.1007/s10456-018-9654-1
Abstract: The miR-200 family, consisting of miR-200a/b/c, miR-141, and miR-429, is well known to inhibit epithelial-to-mesenchymal transition (EMT) in cancer invasion and metastasis. Among the miR-200 family members, miR-200a/b/c and miR-429 have been reported to inhibit… read more here.
Keywords: mir 200; regulatory network; mir 141; angiogenesis ... See more keywords
Interactions between microRNA-200 family and Sestrin proteins in endometrial cancer cell lines and their significance to anoikis
Sign Up to like & getrecommendations! Published in 2019 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-019-03547-2
Abstract: In the present study, we intend to determine whether Sestrin proteins 1, 2, and 3 (SESN1-3) are targets of microRNA-200 family (miR-200) in endometrial cancer (EC) Ishikawa, AN3CA, KLE, and RL 95-2 cell lines and… read more here.
Keywords: sestrin proteins; cell lines; mir 200; anoikis resistance ... See more keywords
Gallic acid and ferulic acid protect the liver from thioacetamide-induced fibrosis in rats via differential expression of miR-21, miR-30 and miR-200 and impact on TFG-β1/Smad 3 signaling.
Sign Up to like & getrecommendations! Published in 2020 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2020.109098
Abstract: This study evaluates the possible protective effects of gallic acid (GaA) and ferulic acid (FeA) against an experimentally induced liver fibrosis by thioacetamide (TAA) in rats. Animals were divided into: control group, GaA group (20 mg/kg/day,… read more here.
Keywords: mir mir; mir; mir 200; group ... See more keywords
The Secretion of miR-200s by a PKCζ/ADAR2 Signaling Axis Promotes Liver Metastasis in Colorectal Cancer
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.03.118
Abstract: SUMMARY Most colorectal cancer (CRC)-related deaths are due to liver metastases. PKCζ is a tumor suppressor in CRC with reduced expression in metastasis. Given the importance of microRNAs (miRNAs) in regulating cellular plasticity, we performed… read more here.
Keywords: secretion; colorectal cancer; mir 200; pkc ... See more keywords
The regulatory effects of metformin on the [SNAIL/miR‐34]:[ZEB/miR‐200] system in the epithelial‐mesenchymal transition(EMT) for colorectal cancer(CRC)
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2018.07.006
Abstract: ABSTRACT The epithelial‐mesenchymal transition (EMT) plays a critical role in cancer progression, metastasis and drug resistance. The transcription factor(TF) and microRNA (miR) chimeric [SNAIL/miR‐34]:[ZEB/miR‐200] unit is the core regulatory system for the EMT process. Here,… read more here.
Keywords: emt; snail mir; mir; mir 200 ... See more keywords
MiR-200 family and cancer: From a meta-analysis view.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular aspects of medicine"
DOI: 10.1016/j.mam.2019.09.005
Abstract: The role of microRNAs (miRNAs) in cancer development was implicated as oncogene or tumor suppressor. One of the miRNA family, the miR-200 family, was mainly characterized as tumor suppressor. However, controversial results were reported. The… read more here.
Keywords: 200 family; mir 200; family; cancer ... See more keywords
The miR-200-Quaking axis functions in tumour angiogenesis
Sign Up to like & getrecommendations! Published in 2019 at "Oncogene"
DOI: 10.1038/s41388-019-0916-1
Abstract: The progression of solid cancers towards a metastatic state is facilitated by tumor angiogenesis. While targeting of angiogenesis is an important therapeutic strategy, its success has been limited by an incomplete understanding of tumor endothelial… read more here.
Keywords: angiogenesis; tumour angiogenesis; mir 200; cancer ... See more keywords
MicroRNA-200 family governs ovarian inclusion cyst formation and mode of ovarian cancer spread
Sign Up to like & getrecommendations! Published in 2020 at "Oncogene"
DOI: 10.1038/s41388-020-1264-x
Abstract: Epidemiologic and histopathologic findings and the laying hen model support the long-standing incessant ovulation hypothesis and cortical inclusion cyst involvement in sporadic ovarian cancer development. MicroRNA-200 (miR-200) family is highly expressed in ovarian cancer. Herewith,… read more here.
Keywords: microrna 200; 200 family; inclusion cyst; mir 200 ... See more keywords
Abstract 3757: miR-200 inhibits the activation of cancer-associated fibroblasts in lung tumor microenvironment
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3757
Abstract: Cancer-associated fibroblasts (CAFs) are key components of the tumor microenvironment and promote cancer progression and metastasis. CAFs are regulated by diverse processes including regulation by miRNAs. To identify miRNAs involved in the regulation of CAF… read more here.
Keywords: cafs; mir 200; tumor microenvironment; associated fibroblasts ... See more keywords
Lineage-specific Expression of miR-200 Family in Human Embryonic Stem Cells during In Vitro Differentiation
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Stem Cells"
DOI: 10.15283/ijsc17013
Abstract: Although microRNAs have emerged as key regulators in diverse cellular processes, the roles of microRNAs are poorly understood in human embryonic stem cells (hESCs) during differentiation into specialized cell types. In this study, we used… read more here.
Keywords: 200 family; stem cells; differentiation; mir 200 ... See more keywords