MicroRNA‐200a suppresses prostate cancer progression through BRD4/AR signaling pathway
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Medicine"
DOI: 10.1002/cam4.2029
Abstract: Prostate cancer is still considered a significant health care challenge worldwide due in part to the distinct transformation of androgen‐dependent prostate cancer (ADPC) into treatment‐refractory castration‐resistant prostate cancer (CRPC). Consequently, there is an urgent need… read more here.
Keywords: prostate cancer; cancer; mir 200a; 200a suppresses ... See more keywords
miR‐200a‐3p promoted cell proliferation and metastasis by downregulating SOX17 in non‐small cell lung cancer cells
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23037
Abstract: Lung cancer has high mortality and incidence rates in which non‐small cell lung cancer (NSCLC) is the primary type of lung cancer that accounts for about 80%–85% of total patients. It has been demonstrated that… read more here.
Keywords: lung cancer; cell; cell proliferation; mir 200a ... See more keywords
Metformin inhibits tumorigenesis in HBV‐induced hepatocellular carcinoma by suppressing HULC overexpression caused by HBX
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26555
Abstract: We aimed to understand whether metformin imposes the inhibitory effect on the HBV‐associated tumorigenesis by regulating the HULC and its downstream signaling pathway. Luciferase assay, RT‐PCR, and Western‐blot, MTT and flow cytometry analysis were performed… read more here.
Keywords: hulc; tumorigenesis; hbv; metformin ... See more keywords
Upregulation of miR‐200a and miR‐204 in MPP+‐treated differentiated PC12 cells as a model of Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Genetics & Genomic Medicine"
DOI: 10.1002/mgg3.548
Abstract: Parkinson's disease (PD) is ranked as the second most common neurodegenerative disorder caused by loss of dopaminergic neurons in the substantia nigra. Micro(mi)RNAs are a class of small noncoding RNAs that regulate gene expression and… read more here.
Keywords: 200a mir; upregulation mir; disease; parkinson disease ... See more keywords
Exosome-derived miR-200a promotes esophageal cancer cell proliferation and migration via the mediating Keap1 expression.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular and cellular biochemistry"
DOI: 10.1007/s11010-022-04353-z
Abstract: Previous studies have reported that exosomes bearing certain microRNAs (miRNAs) are related to the physiological functions of different types of cancer cells. Our study aimed to elucidate the role of miR-200a in esophageal squamous cell… read more here.
Keywords: cancer; expression; 200a promotes; cell ... See more keywords
miR-200a-3p promotes β-Amyloid-induced neuronal apoptosis through down-regulation of SIRT1 in Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Biosciences"
DOI: 10.1007/s12038-017-9698-1
Abstract: The aberrantly expressed microRNAs (miRNAs) including miR-200a-3p have been reported in the brains of Alzheimer’s disease (AD) patients in recent researches. Nevertheless, the role of miR-200a-3p in AD has not been characterized. The purpose of… read more here.
Keywords: induced neuronal; apoptosis; anti mir; neuronal apoptosis ... See more keywords
Neuroprotective effects of overexpressed microRNA-200a on activation of glaucoma-related retinal glial cells and apoptosis of ganglion cells via downregulating FGF7-mediated MAPK signaling pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2018.11.006
Abstract: Glaucoma is a progressive optic neuropathy and is one of the leading causes of blindness in the industrialized countries. The involvement of microRNAs (miRs) has been implicated in regulating the complex biological responses to changes… read more here.
Keywords: glaucoma related; signaling pathway; glaucoma; mapk signaling ... See more keywords
Modulation in miR-200a/SIRT1axis is associated with apoptosis in MPP+-induced SH-SY5Y cells.
Sign Up to like & getrecommendations! Published in 2018 at "Gene"
DOI: 10.1016/j.gene.2018.06.061
Abstract: Previous studies have shown that miR-200a is markedly deregulated in various neurodegenerative disorders including Alzheimer's disease (AD), Multiple Sclerosis (MS) and PD. Furthermore, studies have shown the key role of miR-200a on expression of SIRT1… read more here.
Keywords: modulation mir; 200a sirt1; apoptosis; mir 200a ... See more keywords
Prediction and verification of target of helenalin against hepatic stellate cell activation based on miR-200a-mediated PI3K/Akt and NF-κB pathways.
Sign Up to like & getrecommendations! Published in 2021 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.107208
Abstract: Hepatic stellate cell (HSC) activation is a crucial event in the progress of liver fibrosis. In this study, the target of helenalin was firstly predicted by bioinformatics analysis, and then the prediction was verified by… read more here.
Keywords: pi3k akt; helenalin; 200a mediated; activation ... See more keywords
Overcoming cisplatin resistance of human lung cancer by sinomenine through targeting the miR-200a-3p-GLS axis.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of chemotherapy"
DOI: 10.1080/1120009x.2022.2111490
Abstract: Lung cancer, a malignant disease, is one of the leading causes of patient death. Non-small cell lung cancer (NSCLC) is the most common type of lung cancer. Currently, chemotherapeutic agents such as cisplatin are widely… read more here.
Keywords: lung cancer; sinomenine; cisplatin; cancer ... See more keywords
Downregulation of transcription factor TCTP elevates microRNA-200a expression to restrain Myt1L expression, thereby improving neurobehavior and oxidative stress injury in cerebral palsy rats
Sign Up to like & getrecommendations! Published in 2020 at "Cell Cycle"
DOI: 10.1080/15384101.2020.1717044
Abstract: ABSTRACT Transcription factors have already been proposed to work on some human diseases. Yet the role of translationally controlled tumor protein (TCTP) in cerebral palsy (CP) remains elusive. This study intends to examine the mechanism… read more here.
Keywords: transcription; brain tissues; expression; factor ... See more keywords