miR‐200c, a tumor suppressor that modulate the expression of cancer stem cells markers and epithelial‐mesenchymal transition in colorectal cancer
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26880
Abstract: Colorectal cancer (CRC) is the most frequently diagnosed cancer and the most common gastrointestinal cancer worldwide. Due to the presence of populations of cancer stem cells (CSCs) that cause recurrence, the possibility of cancer treatment… read more here.
Keywords: cancer stem; colorectal cancer; expression; mir 200c ... See more keywords
Anticancer effects of miR‐200c in colorectal cancer through BMI1
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27330
Abstract: Colorectal cancer (CRC) is one of the most leading cancer deaths throughout the world. MiR‐200c has been shown to have a critical role in cancer initiation and progression. In this study, we investigated the miR‐200c… read more here.
Keywords: colorectal cancer; crc tissues; expression; mir 200c ... See more keywords
miR‐200c‐3p spreads invasive capacity in human oral squamous cell carcinoma microenvironment
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DOI: 10.1002/mc.22744
Abstract: Oral squamous cell carcinoma (OSCC) constitutes over 90% of all cancers in the oral cavity. The prognosis for patients with invasive OSCC is poor; therefore, it is important to understand the molecular mechanisms of invasion… read more here.
Keywords: microenvironment; oral squamous; squamous cell; cell carcinoma ... See more keywords
Upregulation of BMI1-suppressor miRNAs (miR-200c, miR-203) during terminal differentiation of colon epithelial cells
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Gastroenterology"
DOI: 10.1007/s00535-022-01865-9
Abstract: MicroRNAs (miRNAs) are key regulators of stem cell functions, including self-renewal and differentiation. In this study, we aimed to identify miRNAs that are upregulated during terminal differentiation in the human colon epithelium, and elucidate their… read more here.
Keywords: mir 203; epithelial cells; mir 200c; colon ... See more keywords
EMT in salivary gland tumors: the expression of microRNAs miR-155 and miR-200c is associated with clinical-pathological parameters
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Biology Reports"
DOI: 10.1007/s11033-021-07033-1
Abstract: Background Epithelial to mesenchymal transition promotes cell adhesion loss, enabling invasion and metastasis. MicroRNAs are a class of small non-codifying RNAs that regulate gene expression. Objectives The aim of this study was to evaluate the expression… read more here.
Keywords: expression; mir; 155 mir; mir 155 ... See more keywords
Yin Yang 1-induced LINC00667 up-regulates pyruvate dehydrogenase kinase 1 to promote proliferation, migration and invasion of cholangiocarcinoma cells by sponging miR-200c-3p
Sign Up to like & getrecommendations! Published in 2020 at "Human Cell"
DOI: 10.1007/s13577-020-00448-1
Abstract: Cholangiocarcinoma (CCA) is one of the most aggressive and lethal malignancies. Long noncoding RNAs (lncRNAs) are being found to play crucial roles in CCA progression. This work aims to investigate the roles of long intergenic… read more here.
Keywords: proliferation migration; yin yang; cca; mir 200c ... See more keywords
HDAC inhibitor suppresses proliferation and invasion of breast cancer cells through regulation of miR‐200c targeting CRKL
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2017.11.008
Abstract: ABSTRACT Although histone deacetylase (HDAC) inhibitors have been shown to effectively induce the inhibition of proliferation and migration in breast cancer, the anticancer mechanism remains poorly understood. Our studies show that miR‐200c was significantly downregulated… read more here.
Keywords: crkl; hdac; mir 200c; breast cancer ... See more keywords
Corrigendum to “Sec23a mediates miR-200c augmented oligometastatic to polymetastatic progression” [EBioMedicine 37 (2018) 47–55]
Sign Up to like & getrecommendations! Published in 2021 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2021.103508
Abstract: Fig. 1. POL possesses stronger metastatic ability than OL in in vitro and in vivo. (a) represent (b) quantification of transwell migration assay of POL and OL. (c) representative images of in quantification of transwell… read more here.
Keywords: sec23a mediates; mediates mir; augmented oligometastatic; 200c augmented ... See more keywords
miR-200c increases the sensitivity of breast cancer cells to Doxorubicin through downregulating MDR1 gene.
Sign Up to like & getrecommendations! Published in 2022 at "Experimental and molecular pathology"
DOI: 10.1016/j.yexmp.2022.104753
Abstract: BACKGROUND Breast cancer (BC) has been known as the most common type of cancer worldwide and resulted in death among women. BC is usually resistant to standard therapies that are significant problems in managing BC… read more here.
Keywords: expression; breast cancer; mdr1; gene ... See more keywords
MiR-200c-3p targets SESN1 and represses the IL-6/AKT loop to prevent cholangiocyte activation and cholestatic liver fibrosis
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DOI: 10.1038/s41374-021-00710-6
Abstract: Cholestasis causes ductular reaction in the liver where the reactive cholangiocytes not only proliferate but also gain a neuroendocrine-like phenotype, leading to inflammatory cell infiltration and extracellular matrix deposition and contributing to the development and… read more here.
Keywords: activation; liver; liver fibrosis; mir 200c ... See more keywords
A proteomic analysis of an in vitro knock-out of miR-200c
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-25240-y
Abstract: Loss of miR-200c is correlated to advanced cancer-subtypes due to increased EMT and decreased treatment efficacy by chemotherapeutics. As miRNAs regulate a multitude of targets, the analysis of differentially expressed proteins upon a genomic knock-out… read more here.
Keywords: knock; analysis vitro; vitro knock; mir 200c ... See more keywords