HIF1A/miR‐20a‐5p/TGFβ1 axis modulates adipose‐derived stem cells in a paracrine manner to affect the angiogenesis of human dermal microvascular endothelial cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29111
Abstract: Angiogenic cytokines secreted by the adipose‐derived stem cells (ADSCs) might promote the angiogenesis of endothelial cells. In the present study, we hypothesize that miR‐20a targets TGFB1 to modulate the transforming growth factor β1 (TGFβ1) secretion… read more here.
Keywords: stem cells; mir 20a; angiogenesis; derived stem ... See more keywords
miR‐20a inhibits hypoxia‐induced autophagy by targeting ATG5/FIP200 in colorectal cancer
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23006
Abstract: Autophagy is a highly conserved lysosome‐mediated protective cellular process in which cytosolic components, including damaged organelles and long‐lived proteins, are cleared. Many studies have shown that autophagy was upregulated in hypoxic regions. However, the precise… read more here.
Keywords: mir 20a; atg5 fip200; cancer; induced autophagy ... See more keywords
Post-transcriptional regulation of MMP2 mRNA by its interaction with miR-20a and Nucleolin in breast cancer cell lines.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular biology reports"
DOI: 10.1007/s11033-021-06261-9
Abstract: Matrix-metalloproteinase-2 (MMP2) is a foremost MMP, governing invasion of breast cancer cells during metastasis. miR-20a was reported to induce mesenchymal to epithelial transition in MDA-MB-231 cells and its endogenous expression varies directly with invasiveness of… read more here.
Keywords: mir 20a; mmp2; post transcriptional; breast cancer ... See more keywords
Functional Assessment of Stroke-Induced Regulation of miR-20a-3p and Its Role as a Neuroprotectant.
Sign Up to like & getrecommendations! Published in 2021 at "Translational stroke research"
DOI: 10.1007/s12975-021-00945-x
Abstract: MicroRNAs have gained popularity as a potential treatment for many diseases, including stroke. This study identifies and characterizes a specific member of the miR-17-92 cluster, miR-20a-3p, as a possible stroke therapeutic. A comprehensive microRNA screening… read more here.
Keywords: mir 20a; sensory motor; treatment; stroke outcomes ... See more keywords
MicroRNA-20a-3p regulates the host immune response to facilitate the mycobacterium tuberculosis infection by targeting IKKβ/NF-κB pathway.
Sign Up to like & getrecommendations! Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.107286
Abstract: BACKGROUND Mycobacterium tuberculosis (M.tb) has evolved to utilize different mechanisms to evade the host immune response. Several microRNAs (miRNAs) have been found to regulate innate immune response in M.tb replication and infection, but the roles… read more here.
Keywords: host immune; mir 20a; infection; immune response ... See more keywords
miR-20a-5p ameliorates ovalbumin (OVA)-induced mouse model of allergic asthma through targeting ATG7-regulated cell death, fibrosis and inflammation.
Sign Up to like & getrecommendations! Published in 2021 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.107342
Abstract: Autophagy plays an essential role in modulating asthma progression. MiR-20a-5p can regulate autophagy, but its effects on allergic asthma are still unclear. The aim of this study was to explore the potential of miR-20a-5p on… read more here.
Keywords: mir 20a; fibrosis; inflammation; ova induced ... See more keywords
MicroRNA-20a-mediated loss of autophagy contributes to breast tumorigenesis by promoting genomic damage and instability
Sign Up to like & getrecommendations! Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2017.193
Abstract: Gene expression analysis of The Cancer Genome Atlas (TCGA) breast cancer data set show that miR-20a is upregulated in human breast cancer, especially in triple-negative subtype. Gene Set Enrichment Analysis suggests that miR-20a expression negatively… read more here.
Keywords: mir 20a; breast cancer; breast tumorigenesis; 20a mediated ... See more keywords
miR-20a regulates sensitivity of colorectal cancer cells to NK cells by targeting MICA
Sign Up to like & getrecommendations! Published in 2019 at "Bioscience Reports"
DOI: 10.1042/bsr20180695
Abstract: Colorectal cancer (CRC) is one of the leading cancer-related causes of deaths in the world. Recently, microRNAs have been reported to regulate the tumor growth, invasion and the immunosuppression. In the present study, we found… read more here.
Keywords: mir 20a; crc cells; 20a regulates; cancer ... See more keywords
An acetylated derivative of vitexin halts MDA-MB-231 cellular progression and improves its immunogenic profile through tuning miR- 20a-MICA/B axis
Sign Up to like & getrecommendations! Published in 2019 at "Natural Product Research"
DOI: 10.1080/14786419.2019.1686372
Abstract: Abstract The activating immune ligands, MICA/B, act as a “kill me” signal through the NKG2D receptor expressed on natural killer (NK) cells. Recently, the oncogenic miR-20a was found to mediate immune escape through repressing MICA/B… read more here.
Keywords: mica; vitexin; mir 20a; acetylated derivative ... See more keywords
Mechanism of methyltransferase like 3 in epithelial-mesenchymal transition process, invasion, and metastasis in esophageal cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Bioengineered"
DOI: 10.1080/21655979.2021.1994721
Abstract: Methyltransferase like 3 (METTL3) has been identified to serve as a definitive inducer in cancer progression. This study sought to analyze the regulatory mechanism of METTL3 in epithelial-mesenchymal transition (EMT), invasion, and metastasis in esophageal… read more here.
Keywords: mir 20a; invasion; methyltransferase like; mettl3 ... See more keywords
MicroRNA-20a-5p regulates the epithelial-mesenchymal transition of human hepatocellular carcinoma by targeting RUNX3.
Sign Up to like & getrecommendations! Published in 2022 at "Chinese medical journal"
DOI: 10.1097/cm9.0000000000001975
Abstract: BACKGROUND MicroRNA-20a (miR-20a) is dysregulated in many types of malignancies, including human hepatocellular carcinoma (HCC), but its expression level and functional significance in HCC are still disputed. We aimed to study the role of miR-20a-5p… read more here.
Keywords: expression; hepatocellular carcinoma; runx3; hcc ... See more keywords