Circulating Exosomal miR-20b-5p Inhibition Restores Wnt9b Signaling and Reverses Diabetes-Associated Impaired Wound Healing.
Sign Up to like & getrecommendations! Published in 2019 at "Small"
DOI: 10.1002/smll.201904044
Abstract: At present, developing therapeutic strategies to improve wound healing in individuals with diabetes remains challenging. Exosomes represent a promising nanomaterial from which microRNAs (miRNAs) can be isolated. These miRNAs have the potential to exert therapeutic… read more here.
Keywords: wound healing; angiogenesis; wnt9b signaling; circulating exosomal ... See more keywords
LncRNA MALAT1 Promotes Oxygen-Glucose Deprivation and Reoxygenation Induced Cardiomyocytes Injury Through Sponging miR-20b to Enhance beclin1-Mediated Autophagy
Sign Up to like & getrecommendations! Published in 2019 at "Cardiovascular Drugs and Therapy"
DOI: 10.1007/s10557-019-06902-z
Abstract: LncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is reported to be highly expressed in myocardial I/R injury and closely related to autophagy. However, the exact biological role of MALAT1 and its underlying mechanism in myocardial… read more here.
Keywords: beclin1; glucose deprivation; malat1; oxygen glucose ... See more keywords
CircHIPK3 regulates the autophagy and apoptosis of hypoxia/reoxygenation-stimulated cardiomyocytes via the miR-20b-5p/ATG7 axis
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DOI: 10.1038/s41420-021-00448-6
Abstract: Autophagy and apoptosis are involved in myocardial ischemia/reperfusion (I/R) injury. Research indicates that circular RNA HIPK3 (circHIPK3) is crucial to cell autophagy and apoptosis in various cancer types. However, the role of circHIPK3 in the… read more here.
Keywords: cardiomyocyte autophagy; autophagy apoptosis; apoptosis; circhipk3 ... See more keywords
Mechanism of M2 macrophage-derived extracellular vesicles carrying lncRNA MEG3 in inflammatory responses in ulcerative colitis
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DOI: 10.1080/21655979.2021.2010368
Abstract: ABSTRACT Ulcerative colitis (UC) is a chronic inflammatory disease of the colon. M2 macrophages possess certain anti-inflammation activity. Accordingly, the current study set out to investigate the potential mechanism of M2 macrophage-derived extracellular vesicles (M2-EVs)… read more here.
Keywords: mir 20b; evs; macrophage derived; mechanism macrophage ... See more keywords
Supplementation of Glial Cell Line-Derived Neurotrophic Factor, Fibroblast Growth Factor 2, and Epidermal Growth Factor Promotes Self-Renewal of Putative Buffalo (Bubalus bubalis) Spermatogonial Stem Cells by Upregulating the Expression of miR-20b, miR-21, and miR-106a.
Sign Up to like & getrecommendations! Published in 2019 at "Cellular reprogramming"
DOI: 10.1089/cell.2018.0034
Abstract: In this study, we investigated the effect of glial cell line-derived neurotrophic factor (GDNF), fibroblast growth factor (FGF) 2, and epidermal growth factor (EGF) on the expression of some self-renewal-related microRNAs (miRs) in putative buffalo… read more here.
Keywords: growth factor; self renewal; factor; growth ... See more keywords
Syndecan-2, negatively regulated by miR-20b-5p, contributes to 5-fluorouracil resistance of colorectal cancer cells via the JNK/ERK signaling pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Acta biochimica et biophysica Sinica"
DOI: 10.1093/abbs/gmab124
Abstract: 5-Fluorouracil (5-FU) resistance has been long considered as an obstacle to the efficacy of chemotherapy in colorectal cancer (CRC). In this study, we demonstrated the role of miR-20b-5p-regulated syndecan-2 (SDC2) in 5-FU resistance of CRC… read more here.
Keywords: signaling pathway; sw480 cells; resistance; erk signaling ... See more keywords
Circulating Plasma Levels of miR-20b, miR-29b and miR-155 as Predictors of Bevacizumab Efficacy in Patients with Metastatic Colorectal Cancer
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms19010307
Abstract: Targeting angiogenesis in the treatment of colorectal cancer (CRC) is a common strategy, for which potential predictive biomarkers have been studied. miRNAs are small non-coding RNAs involved in several processes including the angiogenic pathway. They… read more here.
Keywords: mir 155; hsa mir; mir; colorectal cancer ... See more keywords
MicroRNA-20b-5p promotes ventricular remodeling by targeting the TGF-β/Smad signaling pathway in a rat model of ischemia-reperfusion injury
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Molecular Medicine"
DOI: 10.3892/ijmm.2018.3695
Abstract: Myocardial ischemic injury results from severe impairment of the coronary blood supply and may lead to metabolic and ultrastructural changes, thereby causing irreversible damage. MicroRNA (miR)-20b-5p has been demonstrated to be involved in malignancies of… read more here.
Keywords: group; expression; ventricular remodeling; injury ... See more keywords
MicroRNA-20b promotes cell proliferation via targeting of TGF-β receptor II and upregulates MYC expression in Ewing's sarcoma cells.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of oncology"
DOI: 10.3892/ijo.2017.4155
Abstract: Transforming growth factor-β receptor II (TGFBR2) is implicated in various types of cancer. Most molecules involved in the TGF-β pathway can be degraded by one or more microRNAs (miRNAs). In the present study, we show… read more here.
Keywords: myc expression; ewing sarcoma; expression; expression ewing ... See more keywords
microRNA-20b contributes to high glucose-induced podocyte apoptosis by targeting SIRT7.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular medicine reports"
DOI: 10.3892/mmr.2017.7224
Abstract: Previous reports have indicated that microRNAs (miRNAs) have an important role in the pathogenesis of diabetic nephropathy (DN). Podocyte apoptosis induced by high glucose (HG) is characteristic of DN. However, the role of miRNAs in… read more here.
Keywords: podocyte apoptosis; apoptosis; high glucose; induced podocyte ... See more keywords
Long non-coding RNA NEAT1 participates in ventilator-induced lung injury by regulating miR-20b expression
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2022.12582
Abstract: Long non-coding (lnc)RNA nuclear enriched abundant transcript 1 (NEAT1) has been reported to serve an important role in cancer, but its effects on ventilator-induced lung injury (VILI) remain unclear. The present study aimed to investigate… read more here.
Keywords: mir 20b; lung injury; expression; induced lung ... See more keywords