Micro-RNA-215 and -375 regulate thymidylate synthase protein expression in pleural mesothelioma and mediate epithelial to mesenchymal transition
Sign Up to like & getrecommendations! Published in 2022 at "Virchows Archiv"
DOI: 10.1007/s00428-022-03321-8
Abstract: The standard front-line treatment for pleural mesothelioma (PM) is pemetrexed-based chemotherapy, whose major target is thymidylate synthase (TS). In several cancer models, miR-215 and miR-375 have been shown to target TS, while information on these… read more here.
Keywords: expression; mir 215; 215 mir; mir 375 ... See more keywords
CircHIPK3 regulates melanoma cell behaviors by binding with miR-215-5p to upregulate YY1.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular and cellular probes"
DOI: 10.1016/j.mcp.2020.101644
Abstract: OBJECT To investigate the role of circHIPK3 in melanoma. METHODS Bioinformatics analysis and experiments including RT-qPCR, Pearson's correlation analysis, luciferase reporter, Western blot, and RIP assays were applied to explore the function and mechanism of… read more here.
Keywords: melanoma cell; cell; mir 215; circhipk3 ... See more keywords
Upregulation of miR-215 exerts neuroprotection effects against ischemic injury via negative regulation of Act1/IL-17RA signaling
Sign Up to like & getrecommendations! Published in 2018 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2017.10.046
Abstract: OBJECTIVE This study investigated the role of miR-215 and nuclear factor-κB activator (Act)1 and their mechanisms of action in ischemic stroke. METHODS Cell viability was examined with the 3-(4,5-dimethythiazol-. 2-yl)-2,5-diphenyl tetrazolium bromide assay; cell apoptosis… read more here.
Keywords: upregulation mir; ischemic injury; mir 215; 215 exerts ... See more keywords
Potential plasma microRNAs signature miR-190b-5p, miR-215-5p and miR-527 as non-invasive biomarkers for prostate cancer
Sign Up to like & getrecommendations! Published in 2023 at "Biomarkers"
DOI: 10.1080/1354750x.2022.2163694
Abstract: Abstract Background Prostate cancer (PCa) is the most prevalent (20%) pathological cancer among males globally. MicroRNAs (miRNAs) are short (19–22 nucleotide), conserved, noncoding molecules that regulate post-transcriptional processes either by repressing or degrading mRNA or… read more here.
Keywords: mir 190b; mir 527; plasma; mir ... See more keywords
Long non-coding RNA PCED1B antisense RNA 1 promotes gastric cancer progression via modulating microRNA-215-3p / C-X-C motif chemokine receptor 1 axis.
Sign Up to like & getrecommendations! Published in 2021 at "Bioengineered"
DOI: 10.1080/21655979.2021.1971503
Abstract: Long non-coding RNAs (lncRNAs) emerge as vital modulators and tissue-specific biomarkers of multiple cancers, including gastric cancer (GC). Instead, the expression characteristics, biological function and molecular mechanism of lncRNA PCED1B antisense RNA 1 (PCED1B-AS1) in… read more here.
Keywords: pced1b as1; rna; mir 215; long non ... See more keywords
E2F1 regulates miR-215-5p to aggravate paraquat-induced pulmonary fibrosis via repressing BMPR2 expression.
Sign Up to like & getrecommendations! Published in 2022 at "Toxicology research"
DOI: 10.1093/toxres/tfac071
Abstract: Background Pulmonary fibrosis is considered to be an irreversible lung injury, which can be caused by paraquat (PQ) poisoning. MiRNAs have been demonstrated crucial roles in pulmonary fibrosis caused by numerous approaches including PQ induction.… read more here.
Keywords: expression; pulmonary fibrosis; induced pulmonary; e2f1 ... See more keywords
MicroRNA miR-215-5p Regulates Doxorubicin-induced Cardiomyocyte Injury by Targeting ZEB2
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cardiovascular Pharmacology"
DOI: 10.1097/fjc.0000000000001110
Abstract: Abstract: Doxorubicin (DOX) is a chemotherapeutic drug for treating various cancers. However, the DOX-induced cardiotoxicity greatly limits its clinical application. MicroRNAs are emerged as critical mediators of cardiomyocyte injury. This work explored the function of… read more here.
Keywords: mir 215; dox induced; induced cardiomyocyte; injury ... See more keywords
Upregulation of miR-215 attenuates propofol-induced apoptosis and oxidative stress in developing neurons by targeting LATS2
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Medicine"
DOI: 10.1186/s10020-020-00170-6
Abstract: Background Propofol is an intravenous anesthetic agent that commonly induces significant neuroapoptosis. MicroRNAs (miRNAs) have been reported to participate in the regulation of propofol exposure-mediated neurotoxicity. MiR-215, as one of miRNAs, was found to regulate… read more here.
Keywords: propofol; apoptosis; mir; mir 215 ... See more keywords
Clinical significances and diagnostic utilities of both miR-215 and squamous cell carcinoma antigen-IgM versus alpha-fetoprotein in Egyptian patients with hepatitis C virus-induced hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Clinical and Experimental Gastroenterology"
DOI: 10.2147/ceg.s179832
Abstract: Background Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. It has been widely established that the early detection of HCC enables more treatment options with improvements in prognosis and survival. Objectives The… read more here.
Keywords: scca igm; mir 215; hcc; carcinoma ... See more keywords
Potential Mechanism Underlying Exercise Upregulated Circulating Blood Exosome miR-215-5p to Prevent Necroptosis of Neuronal Cells and a Model for Early Diagnosis of Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.860364
Abstract: Exercise is crucial for preventing Alzheimer’s disease (AD), although the exact underlying mechanism remains unclear. The construction of an accurate AD risk prediction model is beneficial as it can provide a theoretical basis for preventive… read more here.
Keywords: prediction model; alzheimer disease; necroptosis neuronal; mechanism ... See more keywords
Hepatic miR-215 target Rictor and modulation of hepatic insulin signalling in rats
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2019.10031
Abstract: Increasing evidence has suggested that hepatic lipid accumulation is associated with hepatic insulin resistance; however, the underlying mechanism is yet to be determined. It was demonstrated that the levels of microRNA-215 (miR-215) expression in the… read more here.
Keywords: insulin signalling; insulin; hepatic insulin; target ... See more keywords