MiR‐216a‐3p inhibits colorectal cancer cell proliferation through direct targeting COX‐2 and ALOX5
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26336
Abstract: Colorectal Cancer (CRC) is a most common digestive system malignant tumor. Despite recent advance in CRC treatment, searching for efficient biomarker and individual treatment therapy remains an urgent need. Cyclooxygenase‐2 (COX‐2) plays a critical role… read more here.
Keywords: cell proliferation; mir 216a; cox alox5; crc ... See more keywords
MiR-216a alleviates LPS-induced acute lung injury via regulating JAK2/STAT3 and NF-κB signaling
Sign Up to like & getrecommendations! Published in 2019 at "Human Cell"
DOI: 10.1007/s13577-019-00289-7
Abstract: MicroRNAs (miRNAs) play an important role in the progression of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Till now, little is known about the role of miR-216a in ALI/ARDS. In this study,… read more here.
Keywords: lps induced; acute lung; mir 216a; stat3 ... See more keywords
LncRNA DANCR regulates the growth and metastasis of oral squamous cell carcinoma cells via altering miR-216a-5p expression.
Sign Up to like & getrecommendations! Published in 2020 at "Human cell"
DOI: 10.1007/s13577-020-00411-0
Abstract: The study aims to investigate how DANCR can alter the growth and metastasis of oral squamous cell carcinoma (OSCC) cells by regulating miR-216a-5p. The expression of DANCR and miR-216a-5p in OSCC patients and cells were… read more here.
Keywords: mir 216a; expression; growth metastasis; dancr ... See more keywords
MiR-216a-5p/Hexokinase 2 axis regulates uveal melanoma growth through modulation of Warburg effect.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.05.069
Abstract: Hexokinase-2 (HK2), the initial as well as the rate-limiting step in glycolysis, is overexpressed in many human cancers, and correlates with poor clinical outcomes. Aerobic glycolysis is a hallmark of cancer, and drugs targeting its… read more here.
Keywords: uveal melanoma; mir 216a; hexokinase; hk2 ... See more keywords
MiR-216a-5p protects 16HBE cells from H2O2-induced oxidative stress through targeting HMGB1/NF-kB pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.11.060
Abstract: Asthma is a complex, chronic inflammatory disorder of the bronchial tree, and can affect patients of all ages including children. High mobility group box 1 (HMGB1) has been proved as a therapeutic target in children… read more here.
Keywords: 16hbe cells; mir 216a; hmgb1 pathway; targeting hmgb1 ... See more keywords
The miR-216a-Dot1l Regulatory Axis Is Necessary and Sufficient for Müller Glia Reprogramming during Retina Regeneration
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.07.061
Abstract: SUMMARY Unlike the adult mammalian retina, Müller glia (MG) in the adult zebrafish retina are able to dedifferentiate into a ‘‘stem cell’’-like state and give rise to multipotent progenitor cells upon retinal damage. We show… read more here.
Keywords: ller glia; retina regeneration; mir 216a; regeneration ... See more keywords
Knockout of Acinar Enriched microRNAs in Mice Promote Duct Formation But Not Pancreatic Cancer
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-47566-x
Abstract: The pancreatic acinar-enriched miR-216a, miR-216b and miR-217 are encoded within the miR217HG. These miRNAs have been purported to play a tumor suppressive role as their expression is reduced in both human and mouse pancreatic ductal… read more here.
Keywords: mir 216b; mir 216a; mir; mice ... See more keywords
MiR-216a-5p-containing exosomes suppress rTp17-induced inflammatory response by targeting TLR4
Sign Up to like & getrecommendations! Published in 2019 at "Bioscience Reports"
DOI: 10.1042/bsr20190686
Abstract: Syphilis caused by Treponema pallidum (T. pallidum) infection is accompanied by inflammatory injury of tissue, and has a worldwide distribution and increasing incidence over the past decade. Tp17 has been reported to be a strong… read more here.
Keywords: rtp17 induced; mir 216a; 216a containing; induced inflammatory ... See more keywords
Hypoxic ASCs-derived Exosomes Attenuate Colitis by Regulating Macrophage Polarization via miR-216a-5p/HMGB1 Axis.
Sign Up to like & getrecommendations! Published in 2022 at "Inflammatory bowel diseases"
DOI: 10.1093/ibd/izac225
Abstract: BACKGROUND Exosomes derived from mesenchymal stem cells have shown therapeutic effects for colitis. As a more clinically accessible resource, the therapeutic potential of exosomes from adipose-derived stem cells (ASCs) has not been fully elucidated, and… read more here.
Keywords: macrophage polarization; derived exosomes; colitis; macrophage ... See more keywords
The estrogen-regulated lncRNA H19/miR-216a-5p axis alters stromal cell invasion and migration via ACTA2 in endometriosis.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular human reproduction"
DOI: 10.1093/molehr/gaz040
Abstract: Fibrotic tissue may contribute to the origin of some endometriosis-related symptoms, such as chronic pelvic pain and infertility. Alterations in the H19/miR-216a-5p/ACTA2 pathway may mediate the regulation of eutopic endometrial stromal cell (euESC) invasion and… read more here.
Keywords: invasion migration; endometriosis; mir 216a; h19 ... See more keywords
MicroRNA-216a Promotes Endothelial Inflammation by Smad7/IκBα Pathway in Atherosclerosis
Sign Up to like & getrecommendations! Published in 2020 at "Disease Markers"
DOI: 10.1155/2020/8864322
Abstract: Background The endothelium is the first line of defence against harmful microenvironment risks, and microRNAs (miRNAs) involved in vascular inflammation may be promising therapeutic targets to modulate atherosclerosis progression. In this study, we aimed to… read more here.
Keywords: microrna 216a; mir 216a; inflammation; endothelial inflammation ... See more keywords