Co-targeting of miR-126-3p and miR-221-3p inhibits PIK3R2 and PTEN, reducing lung cancer growth and metastasis by blocking AKT and CXCR4 signaling.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular oncology"
DOI: 10.1002/1878-0261.13036
Abstract: Lung cancer is the leading cause of cancer-related death worldwide. Late diagnosis and metastatic dissemination contribute to its low survival rate. Since microRNA (miRNA) deregulation triggers lung carcinogenesis, miRNAs might represent an interesting therapeutic tool… read more here.
Keywords: cancer; mir 221; mir 126; lung cancer ... See more keywords
miR‐221 negatively regulates inflammation and insulin sensitivity in white adipose tissue by repression of sirtuin‐1 (SIRT1)
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26589
Abstract: It is well known that obesity‐induced white adipose tissue inflammation is an important reason for insulin‐resistance and type 2 diabetes mellitus. Sirtuin‐1 (SIRT1) is an important regulator of inflammtion response pathways in white adipose tissue.… read more here.
Keywords: insulin; mir 221; inflammation; white adipose ... See more keywords
MicroRNA‐221 regulates osteosarcoma cell proliferation, apoptosis, migration, and invasion by targeting CDKN1B/p27
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27755
Abstract: MicroRNAs (miRNAs, miR) are of critical importance in growth and metastasis of cancer cells; however, the underlying functions of miRNAs in osteosarcoma (OS) remain largely unknown. This study was aimed to elucidate the role of… read more here.
Keywords: cell; mir 221; migration invasion; proliferation ... See more keywords
LncRNA NEAT1_1 suppresses tumor‐like biologic behaviors of fibroblast‐like synoviocytes by targeting the miR‐221‐3p/uPAR axis in rheumatoid arthritis
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.3a0121-067rrr
Abstract: Fibroblast‐like synoviocytes (FLSs) are the predominant effector cells in the pathological progression of rheumatoid arthritis (RA). Therefore, elucidating the underlying molecular mechanism of the biologic behaviors in RA‐FLSs will be helpful in developing the potent… read more here.
Keywords: mir 221; tumor like; upar axis; biologic behaviors ... See more keywords
Downregulation of miR-221-3p contributes to IL-1β-induced cartilage degradation by directly targeting the SDF1/CXCR4 signaling pathway
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Medicine"
DOI: 10.1007/s00109-017-1516-6
Abstract: Osteoarthritis (OA) is characterized by degradation of chondrocyte extracellular matrix (ECM). Accumulating evidence suggests that microRNAs (miRNAs) are associated with OA, but little is known of their function in chondrocyte ECM degradation. The objective of… read more here.
Keywords: degradation; sdf1 cxcr4; mir 221; ecm degradation ... See more keywords
Plasma let-7i, miR-16, and miR-221 levels as candidate biomarkers for the assessment of ankylosing spondylitis in Mexican patients naïve to anti-TNF therapy
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Rheumatology"
DOI: 10.1007/s10067-019-04509-1
Abstract: Novel biomarkers are needed for the diagnosis and clinical assessment of ankylosing spondylitis (AS). Our objective was to investigate plasma microRNAs differentially expressed between AS patients and controls and to evaluate their potential as biomarkers… read more here.
Keywords: tnf therapy; mir mir; mir 221; anti tnf ... See more keywords
Potential of C1QTNF1-AS1 regulation in human hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-019-03569-w
Abstract: The aim of our study is to explore the regulation of C1QTNF1-AS1 on its target miR-221-3p/SOCS3 in human hepatocellular carcinoma (HCC). To explore the underlying molecular regulation of non-coding RNA for HCC, differentially expressed patterns… read more here.
Keywords: c1qtnf1 as1; hcc; mir 221; as1 ... See more keywords
Clinical impact of circulating oncogenic MiRNA-221 and MiRNA-222 in glioblastoma multiform
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-019-03256-2
Abstract: Glioblastoma multiform (GBM); most fatal brain cancer, is incurable with molecular diversity hence identification of molecular targets that contribute to GBM tumorgenesis will be suitable for the development of diagnostic and treatment strategies. Micro-RNAs (miR);… read more here.
Keywords: mir 222; mirna; mir; mir 221 ... See more keywords
Long Non-coding RNA RMST Worsens Ischemic Stroke via MicroRNA-221-3p/PIK3R1/TGF-β Signaling Pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular neurobiology"
DOI: 10.1007/s12035-021-02632-2
Abstract: Much efforts have been made to probe the mechanism underlying ischemic stroke (IS). This study was proposed to uncover the role of long non-coding RNA rhabdomyosarcoma 2 related transcript (RMST) in IS through microRNA-221-3p (miR-221-3p)/phosphoinositide-3-kinase… read more here.
Keywords: mir 221; tgf; rmst; pik3r1 ... See more keywords
Functional analysis of down-regulated miRNA-221-5p in HeLa cell treated with polyphenol-rich Polyalthia longifolia as regulators of apoptotic HeLa cell death
Sign Up to like & getrecommendations! Published in 2020 at "3 Biotech"
DOI: 10.1007/s13205-020-02193-6
Abstract: MicroRNAs are endogenous small non-coding-RNAs that control gene expression and cancer development. Previous studies reported that Polyalthia longifolia treatment induced apoptotic cell death in HeLa cells by down-regulation of miR-221-5p. Hence, the current study was… read more here.
Keywords: hela cell; mir 221; expression; hela ... See more keywords
Targeting epigenetic pathway with gold nanoparticles for acute myeloid leukemia therapy.
Sign Up to like & getrecommendations! Published in 2018 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2018.03.013
Abstract: Leukemia remains a fatal disease for most patients and novel therapeutic strategies are urgently needed. Aberrant DNA methylation is an epigenetic modification that is important in the initiation and progression of leukemia. Here, we demonstrated… read more here.
Keywords: myeloid leukemia; mir 221; ncl mir; 221 dnmt1 ... See more keywords