The lncRNA 'UCA1' modulates the response to chemotherapy of ovarian cancer through direct binding to miR-27a-5p and control of UBE2N levels.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular oncology"
DOI: 10.1002/1878-0261.13045
Abstract: Ovarian cancer (OC) is the leading cause of death in patients with gynecologic cancers. Due to late diagnosis and resistance to chemotherapy, the 5-year survival rate in patients with OC is below 40%. We observed… read more here.
Keywords: chemotherapy; mir 27a; response; lncrna uca1 ... See more keywords
MiR‐27a downregulates 14‐3‐3θ, RUNX1, AF4, and MLL‐AF4, crucial drivers of blast transformation in t(4;11) leukemia cells
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3736
Abstract: The chromosomal translocation t(4;11)(q21;q23), a hallmark of an aggressive form of acute lymphoblastic leukemia (ALL), encodes mixed‐lineage leukemia (MLL)‐AF4 oncogenic chimera that triggers aberrant transcription of genes involved in lymphocyte differentiation, including HOXA9 and MEIS1.… read more here.
Keywords: af4 mll; mir 27a; mll af4; leukemia ... See more keywords
Silencing of microRNA‐27a facilitates autophagy and apoptosis of melanoma cells through the activation of the SYK‐dependent mTOR signaling pathway
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.29696
Abstract: Melanoma is considered as an aggressive neoplastic transformation and featured with high metastatic potential. Although some studies have provided targets for novel therapeutic interventions, clinical development of targeted drugs for melanoma still remains obscure. Therefore,… read more here.
Keywords: melanoma; autophagy apoptosis; mir 27a; apoptosis melanoma ... See more keywords
MicroRNA-27a promotes tumorigenesis in tongue squamous cell carcinoma by enhancing proliferation, migration and suppressing apoptosis
Sign Up to like & getrecommendations! Published in 2021 at "European Archives of Oto-Rhino-Laryngology"
DOI: 10.1007/s00405-021-06837-y
Abstract: Tongue squamous cell carcinoma (TSCC) is a major subtype of head and neck squamous cell carcinoma (HNSCC), which is an intractable cancer with a poor prognosis. Studies have shown that microRNAs (miRNAs) play an important… read more here.
Keywords: mir 27a; tscc; cell carcinoma; squamous cell ... See more keywords
MiR-27a/b Regulates Liver Regeneration by Posttranscriptional Modification of Tmub1
Sign Up to like & getrecommendations! Published in 2018 at "Digestive Diseases and Sciences"
DOI: 10.1007/s10620-018-5113-5
Abstract: BackgroundTransmembrane and ubiquitin-like domain-containing 1 protein (Tmub1) negatively regulates liver regeneration. However, whether this regulation involves posttranscriptional modification of Tmub1 expression is unknown.AimThe aim of the study was to investigate whether microRNA (miR)-27a/b regulates posttranscriptional… read more here.
Keywords: mir 27a; tmub1; posttranscriptional modification; liver regeneration ... See more keywords
LncRNA FAM230B Promotes Gastric Cancer Growth and Metastasis by Regulating the miR-27a-5p/TOP2A Axis
Sign Up to like & getrecommendations! Published in 2020 at "Digestive Diseases and Sciences"
DOI: 10.1007/s10620-020-06581-z
Abstract: Long non-coding RNAs serve as key components of competing endogenous RNA (ceRNA) networks that underlie tumorigenesis. We investigated the pathogenic roles of lncRNA FAM230B and its molecular mechanism in gastric cancer (GC). The levels of… read more here.
Keywords: mir 27a; gastric cancer; cancer; growth ... See more keywords
Linc-KIAA1737–2 promoted LPS-induced HK-2 cell apoptosis by regulating miR-27a-3p/TLR4/NF-κB axis
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Bioenergetics and Biomembranes"
DOI: 10.1007/s10863-021-09897-1
Abstract: Inflammation and renal cell apoptosis participate in sepsis-induced acute kidney injury. Previous research found the upregulation of long non-coding RNA Linc-KIAA1737–2 in hypoxia- or inflammation-challenged human proximal tubular epithelial cells, but its role in sepsis-induced… read more here.
Keywords: linc kiaa1737; mir 27a; lps induced; cell apoptosis ... See more keywords
Increased Expression of MiR-27a and MiR-24-2 in Esophageal Squamous Cell Carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Gastrointestinal Cancer"
DOI: 10.1007/s12029-019-00232-x
Abstract: Purpose Esophageal squamous cell carcinoma (ESCC) is one of the predominant types of esophageal cancer with poor prognosis which shows high prevalence in eastern countries. Studying microRNAs that were considered for their capabilities such as… read more here.
Keywords: mir 27a; esophageal squamous; mir; expression ... See more keywords
Lysophosphatidic acid receptor 6 regulated by miR-27a-3p attenuates tumor proliferation in breast cancer
Sign Up to like & getrecommendations! Published in 2021 at "Clinical and Translational Oncology"
DOI: 10.1007/s12094-021-02704-8
Abstract: Lysophosphatidic acid (LPA) is a bioactive molecule which participates in many physical and pathological processes. Although LPA receptor 6 (LPAR6), the last identified LPA receptor, has been reported to have diverse effects in multiple cancers,… read more here.
Keywords: mir 27a; breast; breast cancer; receptor ... See more keywords
CircNR3C1 inhibits proliferation of bladder cancer cells by sponging miR-27a-3p and downregulating cyclin D1 expression.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer letters"
DOI: 10.1016/j.canlet.2019.06.018
Abstract: Accumulating evidences suggest that circular RNAs play vital roles in human cancers. Previously, we found that circHIPK3 suppressed invasion of bladder cancer cells via sponging miR-558 and downregulating heparanase expression. In this study, we discovered… read more here.
Keywords: bladder cancer; mir 27a; expression; cancer cells ... See more keywords
MALAT1 enhances gemcitabine resistance in non-small cell lung cancer cells by directly affecting miR-27a-5p/PBOV1 axis.
Sign Up to like & getrecommendations! Published in 2022 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2022.110326
Abstract: OBJECTIVE MALAT1 has been implicated in tumor progression. But the mechanism and role underlying MALAT1 in non-small cell lung cancer (NSCLC) cell resistance to gemcitabine (GEM) remain rarely understood. METHODS Through bioinformatics analysis, we predicted… read more here.
Keywords: malat1; resistance; 27a pbov1; cell ... See more keywords