miR‐16 enhances miR‐302/367‐induced reprogramming and tumor suppression in breast cancer cells
Sign Up to like & getrecommendations! Published in 2020 at "IUBMB Life"
DOI: 10.1002/iub.2249
Abstract: Overexpression of either miR‐302 or miR‐302/367 cluster induces reprogramming of cancer cells and exerts tumor‐suppressive effects by induction of mesenchymal‐to‐epithelial transition, apoptosis and a less proliferative capacity. Several reports have described miR‐16 as a tumor… read more here.
Keywords: 302 367; mir 302; breast cancer; cancer cells ... See more keywords
A novel role for aspirin in enhancing the reprogramming function of miR‐302/367 cluster and breast tumor suppression
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.30264
Abstract: Recent studies have provided evidence for tumor suppressive function of the embryonic stem cell‐specific miR‐302/367 cluster through induction of a reprogramming process. Aspirin has been found to induce reprogramming factors of mesenchymal‐to‐epithelial transition in breast… read more here.
Keywords: breast; mir 302; 367 cluster; cancer ... See more keywords
MiR-302-Mediated Somatic Cell Reprogramming and Method for Generating Tumor-Free iPS Cells Using miR-302.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0290-4_12
Abstract: Human induced pluripotent stem cells (iPSCs) by four factors have the risks of teratoma formation and potential tumorigenicity. To overcome this major hurdle, we examined the mechanism(s) by which the cell cycle genes of embryonic… read more here.
Keywords: mir 302; cycle; biology; cell ... See more keywords
The microRNA and the perspectives of miR-302
Sign Up to like & getrecommendations! Published in 2019 at "Heliyon"
DOI: 10.1016/j.heliyon.2019.e01167
Abstract: MiRNAs are naturally occurring, small, non-coding RNA molecules that post-transcriptionally regulate the expression of a large number of genes involved in various biological processes, either through mRNA degradation or through translation inhibition. MiRNAs play important… read more here.
Keywords: microrna perspectives; mir 302; perspectives mir; pathology ... See more keywords
Expression of the miR-302/367 microRNA cluster is regulated by a conserved long non-coding host-gene
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DOI: 10.1038/s41598-021-89080-z
Abstract: MicroRNAs are important regulators of cellular functions. MiR-302/367 is a polycistronic miRNA cluster that can induce and maintain pluripotency. Here we investigate the transcriptional control and the processing of the miR-302 host-gene in mice. Our… read more here.
Keywords: 302 367; mir 302; long non; gene ... See more keywords
miR-302 Suppresses the Proliferation, Migration, and Invasion of Breast Cancer Cells by Downregulating ATAD2
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DOI: 10.3390/cancers14184345
Abstract: Simple Summary ATPase family AAA domain-containing protein 2 (ATAD2) overexpression is associated with poor survival and disease recurrence in multiple cancers. The current study aimed to investigate the expression and function of ATAD2 in breast… read more here.
Keywords: breast cancer; proliferation migration; cancer; mir 302 ... See more keywords
miR-302 Attenuates Mutant Huntingtin-Induced Cytotoxicity through Restoration of Autophagy and Insulin Sensitivity
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DOI: 10.3390/ijms22168424
Abstract: Huntington’s disease (HD) is an autosomal-dominant brain disorder caused by mutant huntingtin (mHtt). Although the detailed mechanisms remain unclear, the mutational expansion of polyglutamine in mHtt is proposed to induce protein aggregates and neuronal toxicity.… read more here.
Keywords: insulin sensitivity; mir 302; induced cytotoxicity; mutant huntingtin ... See more keywords