MicroRNA signature of small‐cell lung cancer after treatment failure: impact on oncogenic targets by miR‐30a‐3p control
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13339
Abstract: Small‐cell lung cancer (SCLC) is associated with a high mortality rate and limited treatment efficacy. We created a microRNA (miRNA) expression signature by RNA sequencing using specimens from patients with SCLC who had failed treatment.… read more here.
Keywords: cell; mir 30a; treatment; sclc cells ... See more keywords
microRNA‐30a inhibits the liver cell proliferation and promotes cell apoptosis through the JAK/STAT signaling pathway by targeting SOCS‐1 in rats with sepsis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28410
Abstract: Sepsis is a systemic inflammatory response that may be induced by trauma, infection, surgery, and burns. With the aim of discovering novel treatment targets for sepsis, this current study was conducted to investigate the effect… read more here.
Keywords: cell proliferation; mir 30a; socs; liver cell ... See more keywords
lncRNA PVT1 promotes the migration of gastric cancer by functioning as ceRNA of miR‐30a and regulating Snail
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29881
Abstract: Although the incidence and mortality of gastric cancer (GC) are slowly decreasing, the overall prognosis of GC patients with distal metastasis remains dismal. Long non‐coding RNA PVT1 has been verified to function as a tumor… read more here.
Keywords: gastric cancer; pvt1; metastasis; snail ... See more keywords
Circulating microRNA-30a-5p, microRNA-101-3p, microRNA-140-3p and microRNA-141-3p as potential biomarkers for dexmedetomidine response in pediatric patients.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of clinical pharmacology"
DOI: 10.1007/s00228-021-03178-x
Abstract: PURPOSE The aim of this study was to investigate the expression levels of plasma miR-30a-5p, miR-101-3p, miR-140-3p and miR-141-3p and their relationship to dexmedetomidine efficacy and adverse effects in pediatric patients. METHODS The expression levels… read more here.
Keywords: mir 101; mir; 101 mir; mir 30a ... See more keywords
MicroRNA-30a Inhibits Colorectal Cancer Metastasis Through Down-Regulation of Type I Insulin-Like Growth Factor Receptor
Sign Up to like & getrecommendations! Published in 2017 at "Digestive Diseases and Sciences"
DOI: 10.1007/s10620-017-4763-z
Abstract: BackgroundmiR-30a expression is down-regulated and regulates tumor suppressors in various cancers.AimWe investigated the mechanisms underlying the biological role of miR-30a in CRC.MethodsMicroRNA, mRNA, and protein expression were analyzed by quantitative real-time PCR and Western blot.… read more here.
Keywords: insulin like; metastasis; expression; crc ... See more keywords
miR-30a regulates γ-globin expression in erythoid precursors of intermedia thalassemia through targeting BCL11A
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Biology Reports"
DOI: 10.1007/s11033-020-05483-7
Abstract: Patients with β-thalassemia suffer from a lack or absence of the beta-globin chain of normal hemoglobin (Hb). Therefore, an increase in fetal Hb (HbF) levels could improve the clinical status of these patients. Downregulation of… read more here.
Keywords: mir 30a; bcl11a; expression; hbf levels ... See more keywords
miR-30a-5p suppresses breast tumor growth and metastasis through inhibition of LDHA-mediated Warburg effect.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer letters"
DOI: 10.1016/j.canlet.2017.04.034
Abstract: Lactate dehydrogenase A (LDHA), a key enzyme regulating aerobic glycolysis, is overexpressed in many human cancers, and correlates with poor clinical outcomes. Aerobic glycolysis is a hallmark of cancer, and drugs targeting its regulators, including… read more here.
Keywords: inhibition ldha; expression; cancer; mir 30a ... See more keywords
Cadmium-mediated miR-30a-GRP78 leads to JNK-dependent autophagy in chicken kidney.
Sign Up to like & getrecommendations! Published in 2019 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2018.10.019
Abstract: Cadmium-mediated microRNAs have become a heavily researched topic. Few studies mention the regulation of autophagy by cadmium through microRNAs, especially regarding poultry. The kidney is one of the organs most severely affected by cadmium, as… read more here.
Keywords: group; cadmium; autophagy; mir 30a ... See more keywords
Long-term effects of stress early in life on microRNA-30a and its network: Preventive effects of lurasidone and potential implications for depression vulnerability
Sign Up to like & getrecommendations! Published in 2020 at "Neurobiology of Stress"
DOI: 10.1016/j.ynstr.2020.100271
Abstract: Exposure to early life stress can interfere with neurodevelopmental trajectories to increase the vulnerability for psychiatric disorders later in life. With this respect, epigenetic mechanisms play a key role for the long-lasting changes in brain… read more here.
Keywords: early life; exposure; vulnerability; mir 30a ... See more keywords
Layered Double Hydroxide-Loaded miR-30a for the Treatment of Breast Cancer In Vitro and In Vivo
Sign Up to like & getrecommendations! Published in 2023 at "ACS Omega"
DOI: 10.1021/acsomega.2c07866
Abstract: MicroRNAs (miRNAs) play an essential role in cancer therapy, but the disadvantages of its poor inherent stability, rapid clearance, and low delivery efficiency affect the therapeutic efficiency. Loading miRNAs by nanoformulations can improve their bioavailability… read more here.
Keywords: mir 30a; breast cancer; ldh mir;
A p53/miR-30a/ZEB2 axis controls triple negative breast cancer aggressiveness
Sign Up to like & getrecommendations! Published in 2018 at "Cell Death and Differentiation"
DOI: 10.1038/s41418-018-0103-x
Abstract: Inactivation of p53 contributes significantly to the dismal prognosis of breast tumors, most notably triple-negative breast cancers (TNBCs). How the relief from p53 tumor suppressive functions results in tumor cell aggressive behavior is only partially… read more here.
Keywords: p53 mir; breast; axis; 30a zeb2 ... See more keywords