HIF‐1α‐induced upregulated miR‐322 forms a feedback loop by targeting Smurf2 and Smad7 to activate Smad3/β‐catenin/HIF‐1α, thereby improving myocardial ischemia‐reperfusion injury
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DOI: 10.1002/cbin.11954
Abstract: Myocardial ischemia/reperfusion injury (MIRI) is a major cause of heart failure after myocardial infarction. It has been reported that miR‐322 is involved in MIRI progression, while the molecular mechanism of miR‐322 in regulating MIRI progression… read more here.
Keywords: smurf2 smad7; cell; hif; mir 322 ... See more keywords
MicroRNA-322 Cluster Promotes Tau Phosphorylation via Targeting Brain-Derived Neurotrophic Factor
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DOI: 10.1007/s11064-018-2475-1
Abstract: Brain-derived neurotrophic factor (BDNF) is a crucial regulator to support synaptic plasticity and neuronal survival, its significant decrease is a pathophysiological hallmark in Alzheimer’s disease (AD) brains and accounts for poor prognosis. MicroRNAs (miRNAs) interfere… read more here.
Keywords: brain derived; tau phosphorylation; mir 322; derived neurotrophic ... See more keywords
MiR-322-5p is involved in regulating chondrocyte proliferation and differentiation in offspring’s growth plate of maternal gestational diabetes
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DOI: 10.1038/s41598-024-69523-z
Abstract: Pregestational diabetes mellitus (PGDM) has an impact on fetal bone formation, but the underlying mechanism is still obscure. Although miRNAs have been extensively investigated throughout bone formation, their effects on fetal bone development caused by… read more here.
Keywords: differentiation; mir 322; bone; proliferation differentiation ... See more keywords
Inhibition of miR-322-5p Protects Cardiac Myoblast Cells Against Hypoxia-Induced Apoptosis and Injury Through Regulating CIAPIN1.
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DOI: 10.1097/fjc.0000000000000949
Abstract: ABSTRACT Hypoxia leads to insufficient supply of blood and nutrients, which is major incentive for cardiomyocyte injury and apoptosis. Previous studies reported the regulation effects of microRNAs (miRNAs) in myocardial infarction, whereas function and molecular… read more here.
Keywords: cardiac myoblast; myoblast cells; apoptosis; injury ... See more keywords
Sox9-Increased miR-322-5p Facilitates BMP2-Induced Chondrogenic Differentiation by Targeting Smad7 in Mesenchymal Stem Cells
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DOI: 10.1155/2021/9778207
Abstract: Bone morphogenetic protein 2 (BMP2) induces effective chondrogenesis of mesenchymal stem cells (MSCs) by promoting Sox9 expression. However, BMP2 also induces chondrocyte hypertrophy and endochondral ossification by upregulating Smad7 expression, which leads to the disruption… read more here.
Keywords: bmp2; mir 322; chondrogenic differentiation; stem cells ... See more keywords
Diagnostic Value and Regulatory Mechanism of miR-322-5p in Coronary Heart Disease
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DOI: 10.2147/jir.s536945
Abstract: Background Coronary heart disease (CHD) is a heart condition caused by narrowed or blocked coronary arteries. The miR-322-5p is closely related to inflammation and vascular diseases, yet its role in CHD remains unknown. Objective This… read more here.
Keywords: mir 322; heart disease; coronary heart; chd ... See more keywords
TNF Signaling Acts Downstream of MiR-322/-503 in Regulating DM1 Myogenesis
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DOI: 10.3389/fendo.2022.843202
Abstract: Myotonic dystrophy type 1 (DM1) is caused by the expanded CUG repeats and usually displays defective myogenesis. Although we previously reported that ectopic miR-322/-503 expression improved myogenesis in DM1 by targeting the toxic RNA, the… read more here.
Keywords: tnf signaling; myogenesis; dm1; 322 503 ... See more keywords
MicroRNA-322 attenuates aluminum maltolate-induced apoptosis in the human SH-SY5Y neuroblastoma cell line.
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DOI: 10.3892/mmr.2017.6809
Abstract: Aluminum-maltolate (Al‑Malt) is a potent apoptosis inductor, which has been widely reported as an etiologic factor in Alzheimer's disease (AD). MicroRNA-322 (miR‑322) is a vital regulator in various biological processes. The aim of the current… read more here.
Keywords: cell; apoptosis; malt; induced apoptosis ... See more keywords