Functional high-throughput screening reveals miR-323a-5p and miR-342-5p as new tumor-suppressive microRNA for neuroblastoma
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-019-03041-4
Abstract: Current therapies for most non-infectious diseases are directed at or affect functionality of the human translated genome, barely 2% of all genetic information. By contrast, the therapeutic potential of targeting the transcriptome, ~ 70% of the… read more here.
Keywords: 323a mir; mir 323a; mir 342; tumor suppressive ... See more keywords
MiR-323a-3p suppressed the glycolysis of osteosarcoma via targeting LDHA
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DOI: 10.1007/s13577-018-0215-0
Abstract: Accumulating evidence has demonstrated that there is critical involvement of miRNAs in the initiation and progression of cancers. Here, we showed that miR-323a-3p was significantly down-regulated in osteosarcoma (OS) tissues and cell lines. Overexpression of… read more here.
Keywords: targeting ldha; glycolysis; mir 323a; osteosarcoma ... See more keywords
Aberrant Expression of miR-323a-5p in Patients with Refractory Epilepsy Caused by Focal Cortical Dysplasia.
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DOI: 10.1089/gtmb.2016.0096
Abstract: BACKGROUND Epilepsy remains one of the most common clinical neurological disorders. About a third of patients with epilepsy are refractory to drug treatment, mainly as a result of focal cortical dysplasia (FCD). In this study,… read more here.
Keywords: refractory epilepsy; mir 323a; expression; patients refractory ... See more keywords
Tumor‐suppressive miR‐323a inhibits pancreatic cancer cell proliferation and glycolysis through targeting HK‐2
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DOI: 10.1111/pin.13289
Abstract: Pancreatic ductal adenocarcinoma (PDAC) accounts for more than 85% of all malignant pancreatic exocrine tumors and is one of the main causes of cancer‐related fatalities. PDAC is characterized by a high glycolytic rate to ensure… read more here.
Keywords: tumor suppressive; mir 323a; pancreatic cancer; overexpression ... See more keywords
MicroRNA-323a-3p Negatively Regulates NEK6 in Colon Adenocarcinoma Cells
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DOI: 10.1155/2022/7007718
Abstract: Objective The activity of NEK6 is enhanced in several cancer cells, including colon adenocarcinoma (COAD) cells. However, there are few reports on the microRNA (miRNA/miR) regulation of NEK6. In this study, we aimed to investigate… read more here.
Keywords: colon adenocarcinoma; nek6 mir; mir 323a; coad cells ... See more keywords